Yuqing Huo Lab Publications

Selected Publications

  1. Ma Q, Cai Y, Zhang Z, Zhao D, Zhao Y, Xu P, Lu T, Zhang W, Yang Q, Zhou Y, Sudhahar V, Fukai T, Jo H, Xu Y, Huo Y. Purine metabolic adaptation protects the endothelium from disturbed flow-induced DNA damage and atherosclerosis. Proc Natl Acad Sci U S A. 2026 May 5;123(18):e2526299123. doi: 10.1073/pnas.2526299123. Epub 2026 Apr 30. PMID: 42060719.
  2. Zhou Y, Zhao D, Ma Q, Lee S, Roh K, Cai Y, Xu J, Yang Q, Da Q, Liu Z, Ouyang K, Chantemele EJB, Hong M, Miller CL, Malhotra R, Zhang C, Xu S, Huo Y. Targeting adenosine 2A receptor signaling suppresses vascular calcification by restraining smooth muscle osteogenic differentiation. Pharmacol Res. 2025 Nov;221:108012. doi: 10.1016/j.phrs.2025.108012. Epub 2025 Oct 25. PMID: 41201506.
  3. Zhou Y, Zhao D, Ma Q, Xu J, Cai Y, Yang Q, Da Q, Sheridan K, Zhang C, Miller CL, Malhotra R, Xu S, Hong M, Huo Y. Endothelial adenosine receptor 2A loss alleviates diabetic vascular calcification by blocking CREB1-SNAI1-driven EndMT. Pharmacol Res. 2025 Nov;221:107981. doi: 10.1016/j.phrs.2025.107981. Epub 2025 Oct 9. PMID: 41067595.
  4. Da Q, Cai Y, Ma Q, Yang Q, Cao Y, Zhou Y, Zhao D, Liu Z, Xu J, Quan J, Zhang L, Wang R, Jiang X, Liu X, Ouyang K, Han Z, Liu J, Wang T, Zhang C, Weintraub NL, Fulton DJR, Zhao J, Hong M, Li Z, Huo Y. PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth. Cell Rep. 2025 Aug 26;44(8):116071. doi:10.1016/j.celrep.2025.116071. Epub 2025 Jul 29. PMID: 40742808; PMCID: PMC12648754.
  5. Yang Q, Cai Y, Ma Q, Xiong A, Xu P, Zhang Z, Xu J, Zhou Y, Liu Z, Zhao D, Asara J, Li W, Shi H, Caldwell RB, Sodhi A, Huo Y. Inactivation of adenosine receptor 2A suppresses endothelial-to-mesenchymal transition and inhibits subretinal fibrosis in mice. Sci Transl Med. 2024 Mar 6;16(737):eadk3868. doi: 10.1126/scitranslmed.adk3868. Epub 2024 Mar 6. PMID: 38446902; PMCID: PMC11373239.
  6. Xu J, Liu Z, Yang Q, Ma Q, Zhou Y, Cai Y, Zhao D, Zhao G, Lu T, Ouyang K, Hong M, Kim HW, Shi H, Zhang J, Fulton D, Miller C, Malhotra R, Weintraub NL, Huo Y. Adenosine kinase inhibition protects mice from abdominal aortic aneurysm via epigenetic modulation of VSMC inflammation. Cardiovasc Res. 2024 Sep 2;120(10):1202-1217. doi: 10.1093/cvr/cvae093. PMID: 38722818; PMCID: PMC11368124. 
  7. Ma Q, Yang Q, Xu J, Sellers HG, Brown ZL, Liu Z, Bordan Z, Shi X, Zhao D, Cai Y, Pareek V, Zhang C, Wu G, Dong Z, Verin AD, Gan L, Du Q, Benkovic SJ, Xu S, Asara JM, Ben-Sahra I, Barman S, Su Y, Fulton DJR, Huo Y. Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models. Eur Heart J. 2023 Jan 31:ehad044. doi: 10.1093/eurheartj/ehad044. Epub ahead of print. PMID: 36721994.
  8. Liu Z, Shi H, Xu J, Yang Q, Ma Q, Mao X, Xu Z, Zhou Y, Da Q, Cai Y, Fulton DJ, Dong Z, Sodhi A, Caldwell RB, Huo Y. Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy. JCI Insight. 2022 Dec 8;7(23):e160940. doi: 10.1172/jci.insight.160940. PMID: 36264636; PMCID: PMC9746914
  9. Ma Q, Yang Q, Xu J, Zhang X, Kim D, Liu Z, Da Q, Mao X, Zhou Y, Cai Y, Pareek V, Kim HW, Wu G, Dong Z, Song WL, Gan L, Zhang C, Hong M, Benkovic SJ, Weintraub NL, Fulton D Jr, Asara JM, Ben-Sahra I, Huo Y. ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease. Circulation. 2022 Sep 8:101161CIRCULATIONAHA121058901. doi: 10.1161/CIRCULATIONAHA.121.058901. Epub ahead of print. PMID: 36073366. 
  10. Liu Z, Xu J, Ma Q, Zhang X, Yang Q, Wang L, Cao Y, Xu Z, Tawfik A, Sun Y, Weintraub NL, Fulton DJ, Hong M, Dong Z, Smith LEH, Caldwell RB, Sodhi A, Huo Y. Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche. Sci Transl Med. 2020 Aug 5;12(555):eaay1371. doi: 10.1126/scitranslmed.aay1371. PMID: 32759274.
  11. Wang Y, Xu Y, Yan S, Cao K, Zeng X, Zhou Y, Liu Z, Yang Q, Pan Y, Wang X, Boison D, Su Y, Jiang X, Patel VS, Fulton D, Weintraub NL, Huo Y. Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation. Cardiovasc Res. 2020 Feb 17:cvaa040. doi: 10.1093/cvr/cvaa040. Epub ahead of print. PMID: 32065618.

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