Zhu Lab Publications

Selected Publications

Research Articles

Zhao S, Lin Q, Xiong W, Li L, Straub L, Zhang D, Zapata R, Zhu Q, Sun XN, Zhang Z, Funcke JB, Li C, Chen S, Zhu Y, Jiang N, Li G, Xu Z, Wyler SC, Wang MY, Bai J, Han X, Kusminski CM, Zhang N, An Z, Elmquist JK, Osborn O, Liu C, Scherer PE: Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders. Sci Transl Med 2023;15:eade8460

Zhu Q*, Zhu Y*, Hepler C, Zhang Q, Park J, Gliniak C, Henry GH, Crewe C, Bu D, Zhang Z, Zhao S, Morley T, Li N, Kim DS, Strand D, Deng Y, Robino JJ, Varlamov O, Gordillo R, Kolonin MG, Kusminski CM, Gupta RK, Scherer PE: Adipocyte mesenchymal transition contributes to mammary tumor progression. Cell Rep 2022;40:111362 (* equal contribution).

Zhu Y*, Li N, Huang M, Chen X, An YA, Li J, Zhao S, Funcke J-B, Cao J, He Z, Zhu Q, Zhang Z, Wang ZV, Xu L, Williams KW, Li C, Grove K, Scherer PE*: Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention. Acta Pharmaceutica Sinica B 2022 (* co-corresponding).

Zhu Y*, Li N*, Huang M, Bartels M, Dogne S, Zhao S, Chen X, Crewe C, Straub L, Vishvanath L, Zhang Z, Shao M, Yang Y, Gliniak CM, Gordillo R, Smith GI, Holland WL, Gupta RK, Dong B, Caron N, Xu Y, Akgul Y, Klein S, Scherer PE: Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis. Nat Commun 2021;12:4829 (* equal contribution).

Zhang Z, Funcke JB, Zi Z, Zhao S, Straub LG, Zhu Y, Zhu Q, Crewe C, An YA, Chen S, Li N, Wang MY, Ghaben AL, Lee C, Gautron L, Engelking LJ, Raj P, Deng Y, Gordillo R, Kusminski CM, Scherer PE: Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity. Cell Metab 2021;33:1624-1639 e1629.

Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Zhu Y, Liu Y, Gradinaru V, Wu X, Jiang L, Scherer PE, Wang QA: Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue. J Clin Invest 2019;130:247-257.

Zhao S, Zhu Y, Schultz RD, Li N, He Z, Zhang Z, Caron A, Zhu Q, Sun K, Xiong W, Deng H, Sun J, Deng Y, Kim M, Lee CE, Gordillo R, Liu T, Odle AK, Childs GV, Zhang N, Kusminski CM, Elmquist JK, Williams KW, An Z, Scherer PE: Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy. Cell Metab. 2019;30:706-719 e706.

Zhang F, Hao G, Shao M, Nham K, An Y, Wang Q, Zhu Y, Kusminski CM, Hassan G, Gupta RK, Zhai Q, Sun X, Scherer PE, Oz OK (2018). An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents. Cell Metab. 27:252-262 e253.

Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE (2017). Hepatic GALE Regulates Whole Body Glucose Homeostasis by Modulating Tff3 Expression. Diabetes. 66:1–11.

Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE (2016). Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metab. 24(3):420-33.