Weiwei Dang Lab Publications

Publications by Year

Zhang Q, Dang W, Wang MC. Lysosomes Signal through Epigenome to Regulate Longevity across Generations. Science. (2025) In press.

Cheng C, McCauley BS, Matulionis N, Vogelauer M, Schmollinger S, Camacho D, Christofk HR, Dang W, Irwin NAT, and Kurdistani SK. Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in Saccharomyces cerevisiae. Nature Communications. (2025) 11:eadv4082. https://doi.org/10.1126/sciadv.adv4082. PubMed ID: 40215312.

Yu Y, Wang X, Fox J, Yu R, Thakre P, McCauley BS, Nikoloutsos N, Yu Y, Li Q, Hastings PJ, Dang W, Chen K, Ira G. Yeast EndoG prevents genome instability by degrading extranuclear DNA species. Nature Communications. (2024) 15:7653. https://doi.org/10.1038/s41467-024-52147-2. PubMed ID: 39227600.

Yu A, Yu R, Liu H, Ge C, Dang W. SIRT1 safeguards adipogenic differentiation by orchestrating anti-oxidative responses and suppressing cellular senescence. GeroScience. (2023) https://doi.org/10.1007/s11357-023-00863-w. PubMed ID: 37420111.

McCauley BS, Dang W. Mammalian aging driven by transcription going awry. Trends in Genetics. (2023) https://doi.org/10.1016/j.tig.2023.06.006. PubMed ID: 37419698.

McCauley BS*, Sun L*, Yu R, Lee M, Liu H, Leeman DS, Huang Y, Webb AE, Dang W. Altered chromatin states drive cryptic transcription in aging mammalian stem cells. Nature Aging. (2021) 1:684. https://doi.org/10.1038/s43587-021-00091-x. (*equal contribution)

Sun Y*, Yu R*, Guo H-B, Qin H, Dang W. A Quantitative Yeast Aging Proteomics Analysis Reveals Novel Aging Regulators. GeroScience. (2021) https://doi.org/10.1007/s11357-021-00412-3. PubMed ID: 34241809. (*equal contribution)

McCauley BS, Dang W. Loosening chromatin and dysregulated transcription: A perspective on cryptic transcription during mammalian aging. Briefings in Functional Genomics. (2021) elab026. https://doi.org/10.1093/bfgp/elab026. PubMed ID: 34050364.

Yu R*, Cao X*, Sun L, Zhu J, Wasko B, Liu W, Crutcher E, Liu H, Jo MC, Qin L, Kaeberlein M, Han Z, Dang W. Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism. Nature Communications. (2021) 12:1981. https://doi.org/10.1038/s41467-021-22257-2. PubMed ID: 33790287. (*equal contribution)

Guo H-B, Ghafari M, Dang W, Qin H. Protein interaction probability landscapes for yeast replicative aging. Scientific Reports. (2021) 11:7143. https://doi.org/10.1038/s41598-021-86415-8. PubMed ID: 33785798.

Ghafari M, Clark J, Guo H-B, Yu R, Sun Y, Dang W, Qin H. Complementary Performances of Convolutional and Capsule Neural Networks on Classifying Microfluidic Images of Dividing Yeast Cells. PLoS One. (2021) 16:e0246988. https://doi.org/10.1371/journal.pone.0246988. PubMed ID: 33730031.

Liu L, Yan Z, Osia BA, Twarowski J, Sun L, Kramara J, Lee R, Kumar S, Dang W, Ira G, Malkova A. Tracking break-induced replication shows that it stalls at roadblocks. Nature. (2021) https://doi.org/10.1038/s41586-020-03172-w. PubMed ID: 33473214.

Sun L, Dang W. SIRT7 slows down stem cell aging by preserving heterochromatin: a perspective on the new discovery. Protein and Cell. (2020) https://doi.org/10.1007/s13238-020-00735-5. PubMed ID: 32435977.

Yu R, Jo MC, Dang W. Ch. 1: Measuring the Replicative Lifespan of Saccharomyces cerevisiae Using the HYAA Microfluidic Platform. Curran S. (eds) Aging. Methods in Molecular Biology. (2020) 2144:1. https://doi.org/10.1007/978-1-0716-0592-9_1. PubMed ID: 32410020.

Huang B, Zhong D, Zhu J, An Y, Gao M, Zhu S, Dang W, Wang X, Yang B, Xie Z. Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines. Aging Cell. (2020) 19:e13129. https://doi.org/10.1111/acel.13129. PubMed ID: 32157780.

Moruno-Manchon JF, Lejault P, Wang Y, McCauley BS, Honarpisheh P, Scheihing DAM, Singh S, Dang W, Kim N, Urayama A, Zhu L, Monchaud D, McCullough LD, Tsvetkov AS. Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons. eLife. (2020) 9:e52283. https://doi.org/10.7554/eLife.52283. PubMed ID: 32043463.

Yu R, McCauley BS, Dang W. Loss of chromatin structural integrity is a source of stress during aging. Human Genetics. (2020) 139:371. https://doi.org/10.1007/s00439-019-02100-x. PubMed ID: 31900586.

Yu A, Zhou R, Xia B, Dang W, Yang Z, Chen X. NAMPT maintains mitochondria content via NRF2-PPARα/AMPKα pathway to promote cell survival under oxidative stress. Cellular Signalling. (2019) 66:109496. https://doi.org/10.1016/j.cellsig.2019.109496. PubMed ID: 31816398.

Yu R, Sun L, Sun Y, Han X, Qin L, Dang W. Cellular Response to Moderate Chromatin Architectural Defects Promotes Longevity. Science Advances. (2019) 5:eaav1165. https://doi.org/10.1126/sciadv.aav1165. PubMed ID: 31309140.

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang J, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Bohmann D, Gladyshev VN, Seluanov Andrei, Gorbunova V. SIRT6 is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. (2019) 177:622-638. https://doi.org/10.1016/j.cell.2019.03.043. PubMed ID: 31002797.

Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Molecular Cell. (2019) 73:684-698. https://doi.org/10.1016/j.molcel.2019.01.021. PubMed ID: 30773298.

Beaupere C, Dinatto L, Wasko B, Chen RB, VanValkenburg L, Kiflezghi MG,Lee MB, Promislow DEL, Dang W, Kaeberlein M, and Labunskyy VM. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proceedings of the National Academy of Sciences of the United States of America. (2018) 115:9586-91. https://doi.org/10.1073/pnas.1804264115. PubMed ID: 30185560.

Sun L, Yu R, Dang W. Chromatin Architectural Changes during Cellular Senescence and Aging. Genes. (2018) 9:211. https://doi.org/10.3390/genes9040211. PubMed ID: 29659513.

Cao X, Dang W. Ch 15: Histone Modification Changes During Aging: Cause or Consequence?—What We Have Learned About Epigenetic Regulation of Aging From Model Organisms. Epigenetics of Aging and Longevity, Vol 4 Translational Epigenetics. (2018) 4:309-328. https://doi.org/10.1016/B978-0-12-811060-7.00015-2.

Yu A and Dang W. Regulation of stem cell aging by SIRT1 – linking metabolic signaling to epigenetic modifications. Molecular and Cellular Endocrinology. (2017) 455:75-82. https://doi.org/10.1016/j.mce.2017.03.031. PubMed ID: 28392411.

Molina-Serrano D, Schiza V, Stavrou E, Demosthenous C, Oppelt J, Liu W, Bergler H, Dang W, Antonis K. Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity. EMBO Reports. (2016) 17:1829-43. https://doi.org/10.15252/embr.201642540. PubMed ID: 27799288.

Yu R, Dang W. Gearing up for survival – HSP-containing granules accumulate in quiescent cells and promote survival. Microbial Cell. (2016) 3:95-6. https://doi.org/10.15698/mic2016.03.481. PubMed ID: 28362009.

Sun Y, Dang W. The controversy around sirtuins and their functions in aging. Molecular Basis of Nutrition and Aging. ISBN 9780128018163. (2016) Chapter 17.

Jo MC, Liu W, Dang W#, Qin L#. High-throughput analysis of yeast replicative aging using a novel microfluidic system. Proceedings of the National Academy of Sciences of the United States of America. (2015) 112:9364-9. https://doi.org/10.1073/pnas.1510328112. PubMed ID: 26170317. (#co-corresponding authors.)

Sen P*, Dang W*#, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke J, and Berger SL#. H3K36 methylation promotes longevity by enhancing transcription fidelity. Genes & Development. (2015) 29:1362-76. https://doi.org/10.1101/gad.263707.115. PubMed ID: 26159996. (*equal contribution; # co-corresponding authors.)

Qin J, Rajaratnam R, Feng L, Salami J, Barber-Rotenberg J, Domsic J, Reyes-Uribe P, Liu H, Dang W, Berger SL, Villanueva J, Meggers E, Marmorstein R. Development of Organometallic S6K1 Inhibitors. Journal of Medicinal Chemistry. (2015) 58:305-14. https://doi.org/10.1021/jm5011868. PubMed ID: 25356520.

Sen P*, Dang W*#, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke J, and Berger SL#. H3K36 methylation promotes longevity by enhancing transcription fidelity. Genes & Development. (2015) 29:1362-76. https://doi.org/10.1101/gad.263707.115. PubMed ID: 26159996. (*equal contribution; # co-corresponding authors.)

Qin J, Rajaratnam R, Feng L, Salami J, Barber-Rotenberg J, Domsic J, Reyes-Uribe P, Liu H, Dang W, Berger SL, Villanueva J, Meggers E, Marmorstein R. Development of Organometallic S6K1 Inhibitors. Journal of Medicinal Chemistry. (2015) 58:305-14. https://doi.org/10.1021/jm5011868. PubMed ID: 25356520.

McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. The SAGA Histone Deubiquitinase Module Controls Yeast Replicative Lifespan via Sir2 Interaction. Cell Reports. (2014) 8:477-86. https://doi.org/10.1016/j.celrep.2014.06.037. PubMed ID: 25043177.

McCauley BS and Dang W. Histone methylation and aging: Lessons learned from model systems. Biochim Biophys Acta - Gene Regulatory Mechanisms. (2014) 1839:1454-62. https://doi.org/10.1016/j.bbagrm.2014.05.008. PubMed ID: 24859460.

Dang W, Sutphin GL, Dorsey J, Otte GL, Cao K, Perry R, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, and Berger SL. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metabolism. (2014) 19:952-66. https://doi.org/10.1016/j.cmet.2014.04.004. PubMed ID: 24814484.

Dang W. The controversial world of sirtuins. Drug Discovery Today: Technologies. (2014) 12:e9-17. https://doi.org/10.1016/j.ddtec.2012.08.003. PubMed ID: 25027380.

Tsuchiyama S, Kwan E, Dang W, Bedalov A, and Kennedy BK. Sirtuins in Yeast: Phenotypes and Tools. Methods in Molecular Biology. (2013) 1077:11-37. https://doi.org/10.1007/978-1-62703-637-5_2. PubMed ID: 24014397.

Yuan H, Rossetto D*, Mellet H*, Dang W*, Srinivasan M, Hodawadekar S, Ding EC, Speicher K, Abshiru N, Perry R, Speicher D, Thibault P, Verreault A, Berger SL, Sternglanz R, McMahon SB, Côté J, and Marmorstein R. MYST Protein Acetyltransferase Activity Requires Active Site Lysine Autoacetylation. The EMBO Journal. (2012) 31:58-70. https://doi.org/10.1038/emboj.2011.382. PubMed ID: 22020126. (*equal contribution.)

Edwards CR, Dang W, and Berger SL. Histone H4 Lysine 20 of Saccharomyces cerevisiae is monomethylated and functions in subtelomeric silencing. Biochemistry. (2011) 50:10473-83. https://doi.org/10.1021/bi201120q. PubMed ID: 21985125.

Kozak ML, Chavez A, Dang W, Berger SL, Ashok A, Guo X, and Johnson FB. Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction. The EMBO Journal. (2010) 29:158-70. https://doi.org/10.1038/emboj.2009.314. PubMed ID: 19875981.

Dang W, Steffen KK, Perry R, Dorsey J, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, and Berger SL. Histone H4 lysine-16 acetylation regulates cellular lifespan. Nature. (2009) 459:802-7. https://doi.org/10.1038/nature08085. PubMed ID: 19516333.

Sanders BD, Jackson B, Brent M, Taylor AM, Dang W, Berger SL, Schreiber SL, Howitz K and Marmorstein R. Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorganic and Medicinal Chemistry. (2009) 17:7031-41. https://doi.org/10.1016/j.bmc.2009.07.073. PubMed ID: 19734050.

Lin Y, Lu J, Zhang J, Walter W, Dang W, Wan J, Tao S, Qian J, Zhao Y, Boeke JD, Berger SL, and Zhu H. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell. (2009) 136:1073-84. https://doi.org/10.1016/j.cell.2009.01.033. PubMed ID: 19303850.

Dang W and Bartholomew B. Domain architecture of the catalytic subunit in the ISW2-nucleosome complex. Molecular and Cellular Biology. (2007) 27:8306–17. https://doi.org/10.1128/mcb.01351-07. PubMed ID: 17908792.

Dang W, Kagalwala MN, and Bartholomew B. The Dpb4 subunit of ISW2 is anchored to extranucleosomal DNA. Journal of Biological Chemistry. (2007) 282:19418-25. https://doi.org/10.1074/jbc.m700640200. PubMed ID: 17491017.

Dang W*, Kagalwala MN*, and Bartholomew B. Regulation of ISW2 by concerted action of histone H4 tail and extranucleosomal DNA. Molecular and Cellular Biology. (2006) 26:7388-96. https://doi.org/10.1128/mcb.01159-06. PubMed ID: 17015471. (*equal contribution.)

Kagalwala MN, Glaus BJ, Dang W, Zofall M, and Bartholomew B. Topography of the ISW2-Nucleosome Complex: Insights into Nucleosome Spacing and Chromatin Remodeling. The EMBO Journal. (2004) 23:2092-104. https://doi.org/10.1038/sj.emboj.7600220. PubMed ID: 15131696.

Liu Y, Zheng J, Dang W, Ren H, Yu M, and Ru B. The Study of Direct ELISA and Competitive ELISA for Rabbit Metallothionein: Correlation of Induction with Zinc. Analusis. (2000) 28:361-6. https://doi.org/10.1051/analusis:2000280361.