*Co-corresponding author; ¹co-first author
J. Kumar, L. Lackey, J.M. Waldern, A. Dey, A.M. Mustoe, K.M. Weeks, D.H. Mathews, A. Laederach. Quantitative prediction of variant effects on alternative splicing in MAPT using endogenous pre-messenger RNA structure probing. eLife, 2022, 11:e73888 (view publication)
S.W. Olson, A.M.W. Turner, J.W. Arney, I. Saleem, C.A. Weidmann, D.M. Margolis, K.M. Weeks*, A.M. Mustoe*. Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP. Mol. Cell, 2022, 82:1708-1723.E10 (view publication)
C.A. Weidmann, A.M. Mustoe, P.B. Jariwala, J.M. Calabrese, K.M. Weeks. Analysis of RNA–protein networks with RNP-MaP defines functional hubs on RNA. Nature Biotechnol., 2021, 39:347-356 (view publication)
R.S. Dhindsa, B.R. Copeland, A.M. Mustoe, D.B. Goldstein. Natural selection shapes codon usage in the human genome. Am. J. Hum. Genet., 2020, 107: 83-95 (view publication)
A.M. Mustoe, N.N. Lama, P.S. Irving, S.W. Olson, K.M. Weeks. RNA base pairing complexity in living cells visualized by correlated chemical probing. Proc. Natl. Acad. Sci. USA, 2019, 116: 24574-24582 (view publication)
A.M. Mustoe*, M. Corley, A. Laederach, and K.M. Weeks*. mRNA structure regulates translation initiation: A mechanism exploited from bacteria to humans. Biochemistry, 2018, 57: 3537-3539. (view publication)
A.M. Mustoe*¹, S. Busan¹, G.M. Rice¹, C.E. Hajdin, B.K. Peterson, V.M. Ruda, N. Kubica, R. Nutiu, J.L. Baryza, and K.M. Weeks*. Pervasive regulatory functions of mRNA structure revealed by high-resolution SHAPE probing. Cell, 2018, 173: 181-195. (view publication)
Highlighted in: C&EN, Biocentury Innovations, and Nature Chemical Biology
M. Corley, A. Solem, G. Phillips, L. Lackey, B. Ziehr, H.A. Vincent, A.M. Mustoe, S.B.V. Ramos, K.M. Weeks, N.J. Moorman, and A. Laederach. An RNA structure-mediated, post-transcriptional model of human a-1-antitrypsin expression. Proc. Natl. Acad. Sci. U.S.A., 2017, 114: E10244-E10253. (view publication)
M. Daher¹, A.M. Mustoe¹, A. Morriss-Andrews¹, C. L. Brooks III, and N. G. Walter. Tuning RNA folding and function through rational design of junction topology. Nucleic Acids Res., 2017, 45: 9706-9715. (view publication)
A. Krokhotin¹, A.M. Mustoe¹, K. M. Weeks, and N. V. Dokholyan. Direct identification of base-paired RNA nucleotides by correlated chemical probing. RNA, 2017, 23: 6-13. (view publication)
C. A. Weidman¹, A.M. Mustoe¹, and K. M. Weeks. Direct duplex detection: an emerging tool in the RNA structural analysis toolbox. Trends Biochem. Sci, 2016, 41: 734-736. (view publication)
A.M. Mustoe, H. M. Al-Hashimi, C. L. Brooks III. Secondary structure encodes a cooperative tertiary folding funnel in the Azoarcus ribozyme. Nucleic Acids Res., 2016, 44:402-412. (view publication)
A.M. Mustoe, X. Liu, P. Lin, H. M. Al-Hashimi, C. A. Fierke, and C. L. Brooks III. Noncanonical secondary structure stabilizes human mitochondrial tRNASer(UCN) by reducing the entropic cost of tertiary folding. J. Amer. Chem. Soc., 2015, 137: 3592–3599. (view publication)
A. Dickson, A.M. Mustoe, L. Salmon, and C.L. Brooks III. Efficient in-silico exploration of RNA interhelical conformations using Euler angles and WExplore. Nucleic Acids Res., 2014, 42: 12126- 12137. (view publication)
A.M. Mustoe, C.L. Brooks III, and H.M. Al-Hashimi. Topological constraints are major determinants of tRNA tertiary structure and provide basis for tertiary folding cooperativity. Nucleic Acids Res., 2014, 42: 11792-11804. (view publication)
L. R. Ganser, A.M. Mustoe, and H. M. Al-Hashimi. An RNA tertiary switch by modifying how helices are tethered. Genome Biol., 2014, 15: 425-428. (view publication)
A.M. Mustoe, C. L. Brooks III, and H. M. Al-Hashimi. Hierarchy of RNA functional dynamics. Annu. Rev. Biochem., 2014, 83: 441-466. (view publication)
A.M. Mustoe, H. M. Al-Hashimi, and C. L. Brooks III. Coarse-grained models reveal essential contributions of topological constraints to the conformational free energy of RNA bulges. J. Phys. Chem. B., 2014, 118: 2615–27. (view publication)
K. C. Suddala, A. J. Rinaldi, J. Feng, A.M. Mustoe, C. D. Eichhorn, J. A. Liberman, J. E. Wedekind, H. M. Al-Hashimi, C. L. Brooks III, and N. G. Walter. Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure. Nucleic Acids Res., 2013, 41: 10462-75. (view publication)
A. R. Pah, R. Guimerà, A.M. Mustoe, and L. A. N. Amaral. Use of a global metabolic network to curate organismal metabolic networks. Sci. Rep., 2013, 3: 1695. (view publication)
E. A. Dethoff, J. Chugh, A.M. Mustoe, and H. M. Al-Hashimi. Functional complexity and regulation through RNA dynamics. Nature, 2012, 482:322-330. (view publication)
A.M. Mustoe, M. H. Bailor, R. Teixeira, C. L. Brooks III, and H. M. Al-Hashimi. New insights into the fundamental role of topological constraints as a determinant of two-way junction conformation. Nucleic Acids Res., 2012, 40: 892-904. (view publication
M. H. Bailor¹, A.M. Mustoe¹, C. L. Brooks III, and H. M. Al-Hashimi. 3D maps of RNA interhelical junctions. Nature Protoc., 2011, 6:1536-45. (view publication)
M. H. Bailor, A.M. Mustoe, C. L. Brooks III, and H. M. Al-Hashimi. Topological constraints: using RNA secondary structure to model 3D conformation, folding pathways, and dynamic adaptation. Curr. Opin. Struct. Biol., 2011, 21:296-305. (view publication)