Phone
- Primary: (713) 798-7820
- Secondary: (713) 798-7764
Addresses
- Adult Genetics Clinic (Clinic)
- Baylor College of Medicine Medical Center - McNair Campus 7200 Cambridge St. 9th Floor, Suite 9A Houston, Texas 77030 United States (713) 798-7764 Adult Genetics Clinic
Websites
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Positions
- Associate Professor
- Molecular and Human Genetics
- Baylor College of Medicine
- Houston, TX, US
- Director, Clinic for Metabolic and Genetic Disorders of Bone
- Baylor College of Medicine
- Texas, United States
- Director, Clinical Research Division
- Molecular and Human Genetics
- Baylor College of Medicine
- Associate Professor
- Department of Medicine
- Baylor College of Medicine
Education
- MBBS from University of Mysore
- Medical School
- Residency at Gandhi Medical College
- Internal Medicine
- Internship at Fairview Hospital, A Cleveland Clinic Hospital
- Residency at Baylor College Of Medicine
- Clinical Genetics
- Post-Doctoral Fellowship at Baylor College Of Medicine
- Human Genetics
- Residency at Baylor College Of Medicine
- Internal Medicine
Certifications
- American Board of Internal Medicine
- American Board of Medical Genetics and Genomics
- International Society for Clinical Densitometry
Honors & Awards
- Adult Genetics Excellence in Education Award
- 2012, 2013, 2015, 2016
- Clinical Scientist Development Award
- Consultant for Endocrinologic and Metabolic Drug Advisory Committee
- Rising Star Award
- Norton Rose Fulbright Faculty Excellence Award
- Teaching and Evaluation
Professional Interests
- Translational and clinical research focused on inborn errors of metabolism and skeletal dysplasia
Professional Statement
My research interests are focused on translational medicine, specifically, evaluating new and potential therapies for various genetic disorders. I am particularly interested in conducting natural history studies, proof-of-concept pilot studies, and interventional clinical trials in patients with inborn errors of metabolism and skeletal dysplasias.
As the Co-PI for the NIH Rare Disease Clinical Research Network’s Urea Cycle Disorders Consortium, I am actively involved in conducting natural history studies, data-mining projects, and exploratory studies aimed at improving therapies for UCDs. We recently discovered that some distinct features of UCDs could be a result of perturbations of non-ureagenic functions of urea cycle enzymes. In particular, we have shown that nitric oxide (NO) deficiency in the UCD argininosuccinate lyase deficiency (ASLD) contributes to the phenotype of the disorder. We are now translating these molecular findings into the clinical realm by performing clinical trials to evaluate the effects of NO supplementation on vascular and neurocognitive parameters in ASLD.
Another research area of interest is in regards to osteogenesis imperfecta (OI), a heritable form of brittle bone disease. We were the first group to show efficacy of anabolic bone therapy in milder forms of OI. BCM is the primary site for the Brittle Bone Disease Consortium, a newly funded RDCRN Consortium site. We are actively involved in conducting natural history studies in OI to answer clinically relevant questions. In addition, I am the Lead Investigator in a Phase I/II study evaluating the safety and efficacy of TGF inhibition in subjects with severe forms of OI.
Clinical Interests
As an adult clinical geneticist, I provide clinical care for adult patients with a wide variety of heritable conditions. I serve as the Director of the Clinic for Metabolic and Genetic disorders of bone that caters to adult subjects with OI, heritable disorders of bone, early-onset osteoporosis, and other common forms of metabolic bone diseases.
Selected Publications
- "Complete List of Publications on Pubmed."
- Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, Stettner N, Sun Q, Brandis A, Helbling D, Korman S, Itzkovitz S, Dimmock D, Igor Ulitsky, Nagamani SC, Ruppin E and Erez A. "Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.." Nature. 2015 November;527(7578):379-83. Pubmed PMID: 26560030
- Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B. "Requirement of argininosuccinate lyase for systemic nitric oxide production." Nat Med. 2011 November 13;17(12):1619-26. Pubmed PMID: 22081021
- Nagamani SC, Campeau PM, Shchelochkov OA, Premkumar MH, Guse K, Brunetti-Pierri N, Chen Y, Sun Q, Tang Y, Palmer D, Reddy AK, Li L, Slesnick TC, Feig DI, Caudle S, Harrison D, Salviati L, Marini JC, Bryan NS, Erez A, Lee B. "Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria." Am J Hum Genet. 2012 May 4;90(5):836-46. Pubmed PMID: 22541557
- Liu P, Erez A, Nagamani SC, Dhar SU, Kołodziejska KE, Dharmadhikari AV, et al. "Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements." Cell. 2011 September 16;146(6):889-903. Pubmed PMID: 21925314
- Orwoll ES, Shapiro J, Veith S, Wang Y, Lapidus J, Vanek C, Reeder JL, Keaveny TM, Lee DC, Mullins MA, Nagamani SC, Lee B. "Evaluation of teriparatide treatment in adults with osteogenesis imperfecta." J Clin Invest. 2014 February 3;124(2):491-8. Pubmed PMID: 24463451
- Bellur S, Jain M, Cuthbertson D, Krakow D, Shapiro JR, Steiner RD, Smith PA, Bober MB, Hart T, Krischer J, Mullins MA, Byers PH, Pepin M, Durigova M, Glorieux FH, Rauch F, Sutton VR, Lee B, “Members of the BBD Consortium”, and SC Nagamani. "Cesarean delivery is not associated with decreased at-birth fracture rates in osteogenesis imperfecta." Genetics in Medicine. 2015 October Pubmed PMID: 26426884
- Nagamani SC, Shchelochkov OA, Mullins MA, Carter S, Lanpher BC, Sun Q, et al. "A randomized controlled trial to evaluate the effects of high-dose versus low-dose of arginine therapy on hepatic function tests in argininosuccinic aciduria." Mol Genet Metab. 2012 November;107(3):315-21. Pubmed PMID: 23040521
- Burrage LC, Jain M, Gandolfo L, Lee BH; Members of the Urea Cycle Disorders Consortium, Nagamani SC. "Sodium phenylbutyrate decreases plasma branched-chain amino acids in patients with urea cycle disorders." Mol Genet Metab. 2014 July 3;113:131-5. Pubmed PMID: 25042691
- Diaz GA, Krivitzky LS, Mokhtarani M, Rhead W, Bartley J, (...), C S Nagamani S, et al. "Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate." Hepatology. 2013 June;57(6):2171-9. Pubmed PMID: 22961727
- Eble TN, Nagamani SC, Franco LM, Plon SE, Blazo M, Dhar SU. "The practice of adult genetics: a 7-year experience from a single center." Am J Med Genet A. 2013 Pubmed PMID: 23239603
- Nagamani SC, Erez A, Bay C, Pettigrew A, Lalani SR, Herman K, et al. "Delineation of a deletion region critical for corpus callosal abnormalities in chromosome 1q43-q44." Eur J Hum Genet. 2012 February;20(2):176-9. Pubmed PMID: 21934713
- Nagamani SC, Erez A, Bader P, Lalani SR, Scott DA, Scaglia F, Plon SE, Tsai CH, Reimschisel T, Roeder E, Malphrus AD, Eng PA, Hixson PM, Kang SH, Stankiewicz P, Patel A, Cheung SW. "Phenotypic manifestations of copy number variation in chromosome 16p13.11." 2011;19(3):280-6. Pubmed PMID: 21150890
- Nagamani SC, Erez A, Shen J, Li C, Roeder E, Cox S, et al. "Clinical spectrum associated with recurrent genomic rearrangements in chromosome 17q12." Eur J Hum Genet. 2010 March;18(3):278-84. Pubmed PMID: 19844256
- Nagamani SC, Zhang F, Shchelochkov OA, Bi W, Ou Z, Scaglia F, et al. "Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in growth restriction, cognitive impairment, and structural abnormalities of the brain." J Med Genet. 2009 December;46(12):825-33. Pubmed PMID: 19584063
Memberships
- Rolanette and Berdon Lawrence Bone Disease Program of Texas
- American College of Medical Genetics
- American Society of Human Genetics
- American Society for Bone and Mineral Research
Funding
- Co-Principal Investigator for the Urea Cycle Disorders Consortium - #U54HD061221
- Grant funding from NCATS and NICHD for the RDCRN
- Clinical Scientist Development Award
- Grant funding from Doris Duke Charitable Fund
- Principal Investigator, Clinical Translational Core, IDDRC
- Grant funding from NICHD
- Clinical Translational Core Subaward
- Industry-funded studies
- Genzyme, Alexion, Amgen
- NUCDF Fellowship Award
- National Urea Cycle Disorders Foundation
- Nitric Oxide And Bone Homeostasis In Patients With Argininosuccinate Lyase Deficiency - #R01AR071741
- Grant funding from NIAMS
- Nitric Oxide Supplementation As A Therapeutic Intervention In Argininosuccinate Lyase Deficiency - #U54HD061221
- Grant funding from NCATS and NICHD for the RDCRN