Sandesh
Middle Name
C.S.
Nagamani, M.B.B.S, M.D., FACMG
Middle Name
C.S.
Picture
Sandesh
Middle Name
C.S.
Nagamani, M.B.B.S, M.D., FACMG
Middle Name
C.S.
Associate Professor
Positions
- Associate Professor
-
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX US
- Vice Chair of Clinical Research
-
Molecular and Human Genetics
Baylor College of Medicine
- Director, Clinical Translational Core
-
Intellectual and Developmental Disabilities Research Center (IDDRC)
Baylor College of Medicine
- Associate Professor
-
Department of Medicine
Baylor College of Medicine
Addresses
- Adult Genetics Clinic (Clinic)
-
Baylor College of Medicine Medical Center - McNair Campus
7200 Cambridge St.
Houston, TX 77030
United States
Phone: (713) 798-7764
Adult Genetics Clinic
Education
- Residency at Baylor College Of Medicine
- 10/2009 - Houston, Texas United States
- Internal Medicine
- Postdoctoral Training at Baylor College Of Medicine
- 06/2009 - Houston, Texas United States
- Clinical Genetics
- Residency at Baylor College Of Medicine
- 06/2008 - Houston, Texas United States
- Clinical Genetics
- Internship at Fairview Hospital, A Cleveland Clinic Hospital
- 06/2006 - Cleveland, Ohio United States
- Residency at Gandhi Medical College
- 01/2003 - Bhopal, India
- Internal Medicine
- MBBS from University of Mysore
- 01/1999 - Mysore, India
- Medical School
Certifications
- American Board of Medical Genetics and Genomics
- American Board of Internal Medicine
Honors & Awards
- Adult Genetics Excellence in Education Award
- 2012, 2013, 2015, 2016
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Consultant for Endocrinologic and Metabolic Drug Advisory Committee
- Food and Drug Administration, USA (11/2013)
- Rising Star Award
- Baylor College of Medicine (05/2015)
- Norton Rose Fulbright Faculty Excellence Award
- Teaching and Evaluation
- 11/2016
- Norton Rose Fulbright Faculty Excellence Award for Creation of Enduring Materials
- 05/2021
- Co-Principal Investigator, NIH RDCRN's Urea Cycle Disorders Consortium
Professional Statement
My research interests are focused on translational medicine, specifically, evaluating new and potential therapies for various genetic disorders. I am particularly interested in conducting natural history studies, proof-of-concept pilot studies, and interventional clinical trials in patients with inborn errors of metabolism and skeletal dysplasias.As the Co-PI for the NIH Rare Disease Clinical Research Network’s Urea Cycle Disorders Consortium (UCDC), I am actively involved in conducting natural history studies, data-mining projects, and exploratory studies aimed at improving therapies for UCDs. We discovered that some distinct features of UCDs could be a result of perturbations of non-ureagenic functions of urea cycle enzymes. In particular, we have shown that nitric oxide (NO) deficiency in the UCD argininosuccinate lyase deficiency (ASLD) contributes to the phenotype of the disorder. We are now translating these molecular findings into the clinical realm by performing clinical trials to evaluate the effects of NO supplementation on vascular and neurocognitive parameters in ASLD.
Another research area of interest is in regards to osteogenesis imperfecta (OI), a heritable form of brittle bone disease. We were the first group to show efficacy of anabolic bone therapy in milder forms of OI. BCM is the primary site for the Brittle Bone Disease Consortium (BBDC) of the NIH RDCRN. I save as a lead investigator for the consortium and am leading a Phase I/II study evaluating the safety and efficacy of TGF inhibition in subjects with severe forms of OI.
Clinical Interests
As an adult clinical geneticist, I provide clinical care for adult patients with a wide variety of heritable conditions. I serve as the Director of the Clinic for Metabolic and Genetic disorders of bone that caters to adult subjects with OI, heritable disorders of bone, early-onset osteoporosis, and other common forms of metabolic bone diseases.
Teaching Activities
I am actively involved in the teaching and mentoring of medical students and direct one of the preclinical electives for the Genetics and Genomics Pathway. I also serve as the PI for the Career Enhancement Cores of two consortia of the RDCRN namely, UCDC and the BBDC.
Websites
Selected Publications
- "Complete List of Publications on Pubmed." :
- 2. Song IW*, Nagamani SC*, Nguyen D, Grafe I, Sutton VR, Gannon FH, Munivez E, Jiang MM, Tran A, Wallace M, Esposito P, Musaad S, Strudthoff E, McGuire S, Thornton M, Shenava V, Rosenfeld S, Shypailo R, Orwoll E, Lee B "Targeting TGF-β for treatment of osteogenesis imperfecta." J Clin Invest. 2022 : Pubmed PMID: 35113812
- Lee JS, Adler L, Karathia H, Carmel N, Rabinovich S, (...), Nagamani SCS, Unda M, Wilson DM 3rd, Elhasid R, Carracedo A, Samuels Y, Hannenhalli S, Ruppin E, Erez A "Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.." Cell. 2018 174 : 1559-1570.e22.
- Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH "Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension.." Am J Hum Genet.. 2018 103 : 276-287.
- Nagamani SCS, Agarwal U, Tam A, Azamian M, McMeans A, Didelija IC, Mohammad MA, Marini JC "A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers.." Genet Med.. 2018 20 : 708-716.
- Jain M, Tam A, Shapiro JR, Steiner RD, Smith PA, (...), Members of the Brittle Bone Disorders Consortium*, Nagamani SCS "Growth characteristics in individuals with osteogenesis imperfecta in North America: results from a multicenter study.." Genet Med.. 2018 :
- Marini JC, Agarwal U, Didelija IC, Azamian M, Stoll B, Nagamani SC "Plasma Glutamine Is a Minor Precursor for the Synthesis of Citrulline: A Multispecies Study.." J Nutr.. 2017 147 : 549-555..
- Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, Stettner N, Sun Q, Brandis A, Helbling D, Korman S, Itzkovitz S, Dimmock D, Igor Ulitsky, Nagamani SC, Ruppin E and Erez A "Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.." Nature. 2015 November ; 527 (7578): 379-83. Pubmed PMID: 26560030
- Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B "Requirement of argininosuccinate lyase for systemic nitric oxide production." Nat Med. 2011 November 13; 17 (12): 1619-26. Pubmed PMID: 22081021
- Nagamani SC, Campeau PM, Shchelochkov OA, Premkumar MH, Guse K, Brunetti-Pierri N, Chen Y, Sun Q, Tang Y, Palmer D, Reddy AK, Li L, Slesnick TC, Feig DI, Caudle S, Harrison D, Salviati L, Marini JC, Bryan NS, Erez A, Lee B "Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria." Am J Hum Genet. 2012 May 4; 90 (5): 836-46. Pubmed PMID: 22541557
- Orwoll ES, Shapiro J, Veith S, Wang Y, Lapidus J, Vanek C, Reeder JL, Keaveny TM, Lee DC, Mullins MA, Nagamani SC, Lee B "Evaluation of teriparatide treatment in adults with osteogenesis imperfecta." J Clin Invest. 2014 February 3; 124 (2): 491-8. Pubmed PMID: 24463451
- Nagamani SC, Shchelochkov OA, Mullins MA, Carter S, Lanpher BC, Sun Q, et al "A randomized controlled trial to evaluate the effects of high-dose versus low-dose of arginine therapy on hepatic function tests in argininosuccinic aciduria." Mol Genet Metab. 2012 November ; 107 (3): 315-21. Pubmed PMID: 23040521
- Liu P, Erez A, Nagamani SC, Dhar SU, Kołodziejska KE, Dharmadhikari AV, et al "Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements." Cell. 2011 September 16; 146 (6): 889-903. Pubmed PMID: 21925314
- Bellur S, Jain M, Cuthbertson D, Krakow D, Shapiro JR, Steiner RD, Smith PA, Bober MB, Hart T, Krischer J, Mullins MA, Byers PH, Pepin M, Durigova M, Glorieux FH, Rauch F, Sutton VR, Lee B, “Members of the BBD Consortium”, and SC Nagamani "Cesarean delivery is not associated with decreased at-birth fracture rates in osteogenesis imperfecta." Genetics in Medicine. 2015 October ; : Pubmed PMID: 26426884
- 17. Murali CN, Cuthbertson D, Slater B, Nguyen D, Turner A, Harris G, Sutton VR, Lee B, Members of the BBDC, Nagamani SCS. "Pediatric Outcomes Data Collection Instrument is a Useful Patient-Reported Outcome Measure for Physical Function in Children with Osteogenesis Imperfecta." 2020 : Pubmed PMID: 31772349
Memberships
- Rolanette and Berdon Lawrence Bone Disease Program of Texas
- Scientific Program Officer
- American College of Medical Genetics
- Elected Fellow
- American Society for Bone and Mineral Research
- Member
- American Society of Human Genetics
- Member
Funding
- NUCDF Fellowship Award (07/01/2011 - 06/30/2012) National Urea Cycle Disorders Foundation
- Co-Principal Investigator for the Urea Cycle Disorders Consortium - #U54HD061221 (08/01/2019 Grant funding from NCATS, NICHD, NIDDK for the RDCRN
- Principal Investigator, Clinical Translational Core, IDDRC (08/01/2019 Grant funding from NICHD
- Clinical Translational Core Subaward
- Nitric Oxide And Bone Homeostasis In Patients With Argininosuccinate Lyase Deficiency - #R01AR071741 (04/01/2017 Grant funding from NIAMS
- U54 Career Enhancement Core, Brittle Bone Disorders Consortium (08/01/2019 Grant funding from NCATS, NIAMS, NIDCR, NIHMS, NICHD for the RDCRN
Languages
Hindi, Kannada
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