Email

nagamani@bcm.edu

Positions

Professor

Molecular and Human Genetics
Baylor College of Medicine
Houston, TX US

Vice Chair, Clinical Research Affairs

Molecular and Human Genetics
Baylor College of Medicine

Professor

Department of Medicine
Baylor College of Medicine

Director

BCM Intellectual and Developmental Disabilities Research Center
Baylor College of Medicine

Director

BCM Intellectual and Developmental Disabilities Research Center
Clinical Translational Core

Addresses

Adult Genetics Clinic (Clinic)

Baylor College of Medicine Medical Center - McNair Campus
7200 Cambridge St.
Houston, TX 77030
United States
Phone: (713) 798-7820
Adult Genetics Clinic

Education

Residency at Baylor College Of Medicine

10/2009 - Houston, Texas United States

Internal Medicine

Postdoctoral Training at Baylor College Of Medicine

06/2009 - Houston, Texas United States

Clinical Genetics

Residency at Baylor College Of Medicine

06/2008 - Houston, Texas United States

Clinical Genetics

Residency at Fairview Hospital, A Cleveland Clinic Hospital

06/2006 - Cleveland, Ohio United States

Residency at Gandhi Medical College

01/2003 - Bhopal, India

Internal Medicine

MBBS from University of Mysore

01/1999 - Mysore, India

Medical School

Certifications

American Board of Medical Genetics and Genomics

American Board of Internal Medicine

Honors & Awards

Rising Star Award

Baylor College of Medicine (05/2015)

Norton Rose Fulbright Faculty Excellence Award for Teaching and Evaluation

11/2016

Norton Rose Fulbright Faculty Excellence Award for Creation of Enduring Materials

05/2021

Member, Academy of Distinguished Educators at BCM

Clark Faculty Service Award

BCM (05/2023)

Adult Genetics Excellence in Education Award

2012, 2013, 2015, 2016, 2022

Department of Molecular and Human Genetics, Baylor College of Medicine

Doris Duke Foundation Paragon Award for Research Excellence

10/2023

Professional Statement

My research is focused on translational medicine, specifically, evaluating novel potential therapies for various genetic disorders. The main focus of my research program is clinical investigation including conducting natural history studies, proof-of-concept pilot studies, and interventional clinical trials in patients with inborn errors of metabolism and genetic skeletal disorders. I am fortunate to be the Director for the Clinical Research Division of the Department of Molecular and Human Genetics that conducts over 50 clinical studies in various genetic disorders.

Inborn Errors of Metabolism: I serve as a Co-Principal Investigator for the NIH Rare Diseases Clinical Research Network’s (RDCRN's) Urea Cycle Disorders Consortium (UCDC), an international consortium comprising 16 sites in the U.S., Canada, and Europe. The longitudinal, observational, natural history study conducted by the UCDC has collectively enrolled over 900 individuals in this ultra rare disorder. I am actively involved in conducting natural history studies, data-mining projects and exploratory studies aimed at improving therapies for UCDs. As the PI for the Pilot/Feasibility core of the consortium, I am involved in facilitating projects that will develop and validate new biomarkers for disease activity and endpoints that can be used in clinical investigation. As the PI for the Career Enhancement Core for the consortium, I am glad to be a cheerleader for the career advancement of young investigators in the field of inborn errors of metabolism.

Skeletal dysplasia: I am a lead investigator of the NIH Rare Diseases Clinical Research Network’s Brittle Bone Disorders Consortium. I have contributed significantly to the natural history studies of osteogenesis imperfecta, the most common osteodysplasis in humans. I have developed clinical endpoints and biomarkers to assess disease burden from the perspective of clinical trial readiness and have had lead roles in clinical trials evaluating novel therapies for OI including the first disease-specific therapy with anti-transforming growth factor beta antibody. I serve as the site PI at BCM for clinical trials in genetic skeletal disorders that are sponsored by the pharmaceutical industry.

Intellectual and Developmental Disabilities: I serve as the PI and Director for the NICHD-funded Intellectual and Developmental Disabilities Research Center at BCM. Our center supports core facilities that facilitates the translational research activities of more than 80 investigators engaged in advancing research and clinical care for individuals with intellectual and developmental disabilities.

Clinical Interests: As an internist and adult clinical geneticist, I provide care to adults with a wide variety of heritable conditions. As the Director of the Clinic for Metabolic and Genetic disorders of bone, I evaluate and treat patients with osteogenesis imperfecta, heritable disorders of bone, IDD, Mendelian forms of cancer and heritable connective tissue disorders.

Educational Activities: On the educational front, I have been heavily involved in patient-outreach activities and education of young investigators, medical students, graduate trainees, and clinical residents. I have also been actively involved in developing resources for education of families and physicians across our country about specific rare disorders. I have worked with TeleECHO program to implement and deliver virtual training materials to patients and providers. The latter project has used guided-practice model to reduce health disparities in under-served and remote areas through innovative tele-mentoring.

Websites

Selected Publications

• "Complete List of Publications on Pubmed." ;
• Song IW*, Nagamani SC*, Nguyen D, Grafe I, Sutton VR, Gannon FH, Munivez E, Jiang MM, Tran A, Wallace M, Esposito P, Musaad S, Strudthoff E, McGuire S, Thornton M, Shenava V, Rosenfeld S, Shypailo R, Orwoll E, Lee B "Targeting TGF-β for treatment of osteogenesis imperfecta." J Clin Invest. 2022;132:e152571. Pubmed PMID: 35113812
• Murali CN, Cuthbertson D, Slater B, Nguyen D, Turner A, Harris G, Sutton VR, Lee B, Members of the BBDC, Nagamani SCS. "Pediatric Outcomes Data Collection Instrument is a Useful Patient-Reported Outcome Measure for Physical Function in Children with Osteogenesis Imperfecta." Genet Med. 2020;22:581-589. Pubmed PMID: 31772349
• Lee JS, Adler L, Karathia H, Carmel N, Rabinovich S, (...), Nagamani SCS, Unda M, Wilson DM 3rd, Elhasid R, Carracedo A, Samuels Y, Hannenhalli S, Ruppin E, Erez A "Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.." Cell. 2018;174:1559-1570.e22. Pubmed PMID: 30100185

Memberships

Rolanette and Berdon Lawrence Bone Disease Program of Texas

Member

American College of Medical Genetics

Elected Fellow

American Society for Bone and Mineral Research

Member

American Society of Human Genetics

Member

Funding

Co-Principal Investigator for the NIH RDCRN's Urea Cycle Disorders Consortium - #U54HD061221

( 08/01/2014 )

Grant funding from NCATS, NICHD, NIDDK for the RDCRN

Principal Investigator, Clinical Translational Core, IDDRC - #P50HD103555

( 08/01/2019 )

Grant funding from NICHD

Nitric Oxide And Bone Homeostasis In Patients With Argininosuccinate Lyase Deficiency - #R01AR071741

( 04/01/2017 )

Grant funding from NIAMS

U54 Career Enhancement Core, Brittle Bone Disorders Consortium - #AR068069

( 08/01/2019 )

Grant funding from NCATS, NIAMS, NIDCR, NIHMS, NICHD for the RDCRN

Languages

Hindi, Kannada