Positions
- Professor
-
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, US
- Vice Chair, Clinical Research Affairs
-
Molecular and Human Genetics
Baylor College of Medicine
- Professor
-
Department of Medicine
Baylor College of Medicine
- Director
-
BCM Intellectual and Developmental Disabilities Research Center
Baylor College of Medicine
- Director
-
BCM Intellectual and Developmental Disabilities Research Center
Clinical Translational Core
Addresses
- Adult Genetics Clinic (Clinic)
-
Baylor College of Medicine Medical Center - McNair Campus
7200 Cambridge St.
Houston, TX, 77030
United States
Phone: (713) 798-7820
Adult Genetics Clinic
Education
- Residency at Baylor College Of Medicine
- 10/2009 - Houston, Texas, United States
- Internal Medicine
- Postdoctoral Training at Baylor College Of Medicine
- 06/2009 - Houston, Texas, United States
- Clinical Genetics
- Residency at Baylor College Of Medicine
- 06/2008 - Houston, Texas, United States
- Clinical Genetics
- Residency at Fairview Hospital, A Cleveland Clinic Hospital
- 06/2006 - Cleveland, Ohio, United States
- Residency at Gandhi Medical College
- 01/2003 - Bhopal, India
- Internal Medicine
- MBBS from University of Mysore
- 01/1999 - Mysore, India
- Medical School
Certifications
- American Board of Medical Genetics and Genomics
- American Board of Internal Medicine
Honors & Awards
- Rising Star Award
- Baylor College of Medicine (05/2015)
- Norton Rose Fulbright Faculty Excellence Award for Teaching and Evaluation
- (11/2016)
- Norton Rose Fulbright Faculty Excellence Award for Creation of Enduring Materials
- (05/2021)
- Member, Academy of Distinguished Educators at BCM
- Clark Faculty Service Award
- BCM (05/2023)
- Adult Genetics Excellence in Education Award
- 2012, 2013, 2015, 2016, 2022
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Doris Duke Foundation Paragon Award for Research Excellence
- (10/2023)
Professional Statement
I am an internist and a clinical geneticist who is focused on improving clinical care in individuals with genetic disorders. The focus of my research program is clinical investigation including conducting natural history studies, proof-of-concept pilot studies, and interventional clinical trials in individuals with inborn errors of metabolism and skeletal dysplasias.
Inborn Errors of Metabolism: I served as Multiple Principal Investigator (MPI) for the NIH Rare Diseases Clinical Research Network’s Urea Cycle Disorders Consortium (UCDC) and contact PI for the Pilot/Feasibility core and the career enhancement core of the consortium. The UCDC has implemented 19 studies that have collectively enrolled a more than1600 participants, trained nearly 30 early career investigators, and facilitated the development of novel biomarkers, clinical endpoints, and therapies for urea cycle disorders.
Skeletal dysplasia: As a lead investigator of the NIH Rare Diseases Clinical Research Network’s Brittle Bone Disorders Consortium, I am involved in conducting natural history studies and interventional clinical trials in individuals with osteogenesis imperfecta, the most common osteodysplasia in humans. I have developed clinical endpoints and biomarkers to assess disease burden from the perspective of clinical trial readiness and had lead roles in clinical trials evaluating novel therapies for OI including the first disease-specific therapy with anti-transforming growth factor beta antibody.
Clinical Interests: As an internist and clinical geneticist, I provide care to adults with a wide variety of heritable conditions including osteogenesis imperfecta, genetic skeletal disorders, intellectual and developmental disabilities, Mendelian forms of cancer, and heritable connective tissue disorders.
Intellectual and Developmental Disabilities Research Center: I serve as MPI and Director for the NICHD-funded Intellectual and Developmental Disabilities Research Center at BCM. Our center supports translational research activities of more than 80 investigators engaged in advancing research and clinical care for individuals with intellectual and developmental disabilities.
Educational Activities: On the educational front, I have been heavily involved in patient-outreach activities and education of early career investigators. I have assisted in developing resources for education of families and physicians across our country about specific rare disorders. I have worked with the TeleECHO program to implement and deliver virtual training materials to patients and providers. The latter project has used guided-practice model to reduce health disparities in under-served and remote areas through innovative tele-mentoring.
Inborn Errors of Metabolism: I served as Multiple Principal Investigator (MPI) for the NIH Rare Diseases Clinical Research Network’s Urea Cycle Disorders Consortium (UCDC) and contact PI for the Pilot/Feasibility core and the career enhancement core of the consortium. The UCDC has implemented 19 studies that have collectively enrolled a more than1600 participants, trained nearly 30 early career investigators, and facilitated the development of novel biomarkers, clinical endpoints, and therapies for urea cycle disorders.
Skeletal dysplasia: As a lead investigator of the NIH Rare Diseases Clinical Research Network’s Brittle Bone Disorders Consortium, I am involved in conducting natural history studies and interventional clinical trials in individuals with osteogenesis imperfecta, the most common osteodysplasia in humans. I have developed clinical endpoints and biomarkers to assess disease burden from the perspective of clinical trial readiness and had lead roles in clinical trials evaluating novel therapies for OI including the first disease-specific therapy with anti-transforming growth factor beta antibody.
Clinical Interests: As an internist and clinical geneticist, I provide care to adults with a wide variety of heritable conditions including osteogenesis imperfecta, genetic skeletal disorders, intellectual and developmental disabilities, Mendelian forms of cancer, and heritable connective tissue disorders.
Intellectual and Developmental Disabilities Research Center: I serve as MPI and Director for the NICHD-funded Intellectual and Developmental Disabilities Research Center at BCM. Our center supports translational research activities of more than 80 investigators engaged in advancing research and clinical care for individuals with intellectual and developmental disabilities.
Educational Activities: On the educational front, I have been heavily involved in patient-outreach activities and education of early career investigators. I have assisted in developing resources for education of families and physicians across our country about specific rare disorders. I have worked with the TeleECHO program to implement and deliver virtual training materials to patients and providers. The latter project has used guided-practice model to reduce health disparities in under-served and remote areas through innovative tele-mentoring.
Selected Publications
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Nagamani SCS, Ali S, Izem R, Schady D, Masand P, Shneider BL, Leung DH, Burrage LC. " Biomarkers for liver disease in urea cycle disorders " Mol Genet Metab. 2021 Jun ; 133 : 148-156.
Pubmed PMID: 33846069. -
Song IW*, Nagamani SC*, Nguyen D, Grafe I, Sutton VR, Gannon FH, Munivez E, Jiang MM, Tran A, Wallace M, Esposito P, Musaad S, Strudthoff E, McGuire S, Thornton M, Shenava V, Rosenfeld S, Shypailo R, Orwoll E, Lee B. " Targeting TGF-β for treatment of osteogenesis imperfecta " J Clin Invest. 2022 ; 132 : e152571.
Pubmed PMID: 35113812. -
Murali CN, Cuthbertson D, Slater B, Nguyen D, Turner A, Harris G, Sutton VR, Lee B, Members of the BBDC, Nagamani SCS.. " Pediatric Outcomes Data Collection Instrument is a Useful Patient-Reported Outcome Measure for Physical Function in Children with Osteogenesis Imperfecta " Genet Med. 2020 ; 22 : 581-589.
Pubmed PMID: 31772349.
Memberships
- Rolanette and Berdon Lawrence Bone Disease Program of Texas
- Member
- American College of Medical Genetics
- Elected Fellow
- American Society for Bone and Mineral Research
- Member
- American Society of Human Genetics
- Member
Funding
-
Co-Principal Investigator for the NIH RDCRN's Urea Cycle Disorders Consortium
#U54HD061221 - (08/01/2014)
- Grant funding from NCATS, NICHD, NIDDK for the RDCRN
-
Principal Investigator, Clinical Translational Core, IDDRC
#P50HD103555 - (08/01/2019)
- Grant funding from NICHD
-
Nitric Oxide And Bone Homeostasis In Patients With Argininosuccinate Lyase Deficiency
#R01AR071741 - (04/01/2017)
- Grant funding from NIAMS
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U54 Career Enhancement Core, Brittle Bone Disorders Consortium
#AR068069 - (08/01/2019)
- Grant funding from NCATS, NIAMS, NIDCR, NIHMS, NICHD for the RDCRN
-
Intellectual and Developmental Disabilities Research Center
#P50 HD103555 - Grant funding from NICHD
- PI
-
Career Enhancement Core
#U54 HD061221 - Grant funding from NCATS, NICHD, NIDDK for the RDCRN
-
Pilot Feasibility Core
#U54 HD061221 - Grant funding from NCATS, NICHD, NIDDK
Languages
Hindi, Kannada
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