Associate Professor
Biochemistry and Molecular Biology
Baylor College of Medicine
Houston, TX, US
Adjunct Associate Professor
Rice University
Adjunct Associate Professor
University of Illinois at Urbana-Champaign
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States


Lewis Thomas Fellow from Princeton University
Ph.D. (Physics) from Tel Aviv University
M.Sc. (Physics) from Tel Aviv University
B.Sc. (Physics) from The Technion - Israel Institute Of Technology

Honors & Awards

Career Award
Young Investigators Award

Professional Interests

  • Biophysics and Computational Biology
  • Mouse and Rat
  • Bacteria and Phage
  • Fly and Worm
  • Synthetic Biology and Systems Biology
  • Stem Cell Biology and Cell Fate Determination
  • Gene Expression and Regulation
  • Cancer
  • Development and Evolution

Professional Statement

The goal of my lab is to form a quantitative narrative for fundamental processes in the living cell. This narrative will be based on precise measurements performed in individual cells, at the level of individual molecules and discrete events. To achieve this level of description, we are using a synthesis of approaches from multiple disciplines: methods from classical molecular biology and biochemistry; single-cell fluorescence microscopy; advanced image- and data analysis algorithms; theoretical biophysical modeling and stochastic simulations.

Selected Publications

  • Leonardo A Sepúlveda, Heng Xu, Jing Zhang, Mengyu Wang, Ido Golding. "Measurement of gene regulation in individual cells reveals rapid switching between promoter states." Science. 2016
  • Sanchez A, Golding I. "Genetic determinants and cellular constraints in noisy gene expression." Science. 2013
  • So LH, Ghosh A, Zong C, Sepúlveda LA, Segev R, Golding I. "General properties of transcriptional time series in Escherichia coli." Nat. Genet.. 2011
  • Zeng L, Skinner SO, Zong C, Sippy J, Feiss M, Golding I. "Decision making at a subcellular level determines the outcome of bacteriophage infection." Cell. 2010
  • Golding I, Paulsson J, Zawilski SM, Cox EC. "Real-time kinetics of gene activity in individual bacteria." Cell. 2005