David R Rowley, Ph.D.

Professor

(713) 798-6220

Email

drowley@bcm.edu

Positions

Professor: Dan L Duncan Comprehensive Cancer Center
Department of Molecular and Cellular Biology
Baylor College of Medicine
Houston, TX, US

Faculty Senator: Education Committee Chair
Baylor College of Medicine
Houston, Texas, United States

Leader, Tumor Biology Program: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Assistant Dean of the Foundational Sciences: School of Medicine
Baylor College of Medicine

Addresses

BCM-MD Anderson Hall (Office): Room: BCMA-514B
Houston, TX, 77030
United States

Education

BS from University of Iowa: 05/1975 - Iowa City, Iowa, United States; Graduated with Honors

PhD from University Of Iowa: 01/1980 - Iowa City, Iowa, United States; Anatomy

Postdoctoral Fellowship at Baylor College of Medicine: 01/1984 - Houston, Texas, United States

Honors & Awards

Faculty Excellence Award: Teaching and Evaluation; Fullbright & Jaworski L.L.P. (01/2001 - 01/2002)

Outstanding Teacher Award: John T. McGovern (01/2004 - 01/2005)

Presidential Award for Excellence in Education: Barbara and Corbin J. Roberston, Jr. (01/2007 - 01/2008)

The John K. Lattimer Award: The American Urological Association (01/2009 - 01/2009)

Excellence in Graduate Education Award: Marc Dresden (01/2011 - 01/2012)

Professional Interests

Mechanisms of reactive stroma in cancer progression.

Professional Statement

Dr. Rowley is a leader in the field of stromal-epithelial interactions and the genesis of reactive stroma in the tumor microenvironment. His laboratory was the first to identify and characterize reactive stroma myofibroblasts as a key component of the microenvironment in prostate cancer and benign hyperplasia (BPH). He has focused on prostate cancer research for over 30 years. His laboratory has focused on the evolution of microenvironment stroma from stem cells and how this affects disease progression using several novel model systems that address the origins of CAFs / myofibroblasts and their biology. Dr. Rowley has been involved in many individual investigator grant projects and has lead both U54 and U01 Tumor Microenvironment Network (TMEN) NCI funded group projects. In addition, Dr. Rowley has many years of experience as an educator and mentor to graduate students and medical students at the bench and in the classroom.

Websites

VIICTR Publications List

Selected Publications

Kim W, Barron DA, San Martin R, Chan KS, Tran LL, Yang F, Ressler SJ, Rowley DR. " RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation " Proc Natl Acad Sci USA. 2014 Nov 18; 111 (46) : 16389-16394.
Pubmed PMID: 25313057.
Yang F, Zhang Y, Ressler SJ, Ittmann MM, Ayala GE, Dang TD, Wang F, Rowley DR. " FGFR1 is Essential for Prostate Cancer Progression and Metastasis. " Cancer Res.. 2013 Apr 10;
Pubmed PMID: 23576558.
Ressler SJ, Dang TD, Wu SM, Tse DY, Gilbert BE, Vyakarnam A, Yang F, Schauer IG, Barron DA, Rowley DR.. " WFDC1 Is a Key Modulator of Inflammatory and Wound Repair Responses " Am J Pathol. 2014 ; 184 (11) : 2951-2964.
Pubmed PMID: 4215025.
Rowley D.R.. " Reprogramming the tumor stroma: a new paradigm " Cancer Cell. 2014 ; 26 (4) : 451-2.
Pubmed PMID: 25314074.