Positions
- Assistant Professor
-
Pediatrics
Neurology
Baylor College of Medicine
Houston, TX US
- TCH faculty scholar
-
Texas Children Hospital
Addresses
- Jan and Dan Duncan Neurological Research Institute (Office)
-
1250 Moursund St.
Room: 0950.21
Houston, TX 77030
United States
Education
- PhD from Zhejiang University
- 06/2018 - Hangzhou, Zhejiang China
- Neurobiology
- Postdoctoral Fellowship at Baylor College of Medicine
- 08/2023 - Houston, Texas United States
- BS from Nanjing agricultural University
- 06/2012 - Nanjing, Jiangsu China
- Biotechnology
Professional Statement
Obesity serves as a pivotal risk factor for diabetes, fatty liver diseases, cardiovascular disorders, and cancer. Obesity arises from an imbalance between energy intake and expenditure, predominantly orchestrated by the central nervous system (CNS). Our research focuses on the interplay between the central nervous system and systemic energy homeostasis. The ultimate goal is to identify therapeutic targets for combating obesity and metabolic disease.Selected Publications
- He Y*, Brouwers B*, Liu H*, et al. "Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior.." Nat Med. 2022; Pubmed PMID: 36536256
- Li V L*, He Y*, Contrepois K, et al. "An exercise-inducible metabolite that suppresses feeding and obesity." Nature. 2022 Jun 15;
- He Y, Wei M, Wu Y, Qin H, Li W, Ma X, Cheng J, Ren J, Shen Y, Chen Z, Sun B, Huang FD, Shen Y, Zhou YD. "Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate.." Nat Commun.. 2019 Mar 13; Pubmed PMID: 30867420
- Liu H*, He Y*, Bai J*, et al. "Hypothalamic Grb10 enhances leptin signalling and promotes weight loss.." Nat Metab.. 2023; Pubmed PMID: 36593271
- Yang He* Hailan Liu* Na Yin* , et al. "Barbadin Potentiates Long-Term Effects of Lorcaserin on POMC Neurons and Weight Loss." J Neurosci.. 2021 Jun 30; Pubmed PMID: 34031163
- Du R*, Zhu X*, Wu S*, Zhang X*, He Y*, Zhang K, He X, Wang X, Sun Y, Wang Q, Zhang H, Tian M. "PET imaging of metabolic changes after neural stem cells and GABA progenitor cells transplantation in a rat model of temporal lobe epilepsy.." Eur J Nucl Med Mol Imaging.. 2019 Oct; Pubmed PMID: 31338549
- Hailan Liu*, Yang He*, et al. "Defining vitamin D receptor expression in the brain using a novel VDRCre mouse." J Comp Neurol..; Pubmed PMID: 33368246
- Mishra I, Xie WR, Bournat JC, He Y, et al. "Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor." Cell Metab. 2022; Pubmed PMID: 35298903
- Hao S, Yang H, Wang X, He Y, Xu H, Wu X, Pan L, Liu Y, Lou H, Xu H, Ma H, Xi W, Zhou Y, Duan S, Wang H. "The Lateral Hypothalamic and BNST GABAergic Projections to the Anterior Ventrolateral Periaqueductal Gray Regulate Feeding.." Cell Rep.. 2019 Jul 16; Pubmed PMID: 31315042
- Juan Chen*, Yang He*, Yan Wu, Hang Zhou, Li-Da Su, Wei-Nan Li, Richard W Olsen, Jing Liang, Yu-Dong Zhou and Yi Shen "Single ethanol withdrawal regulates extrasynaptic δ-GABAA receptors via PKCδ Activation." Front Mol Neurosci.. 2018 Apr 26; Pubmed PMID: 29755316
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