William R. Lagor, Ph.D.
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Positions
- Kyle and Josephine Morrow Endowed Professor
-
Integrative Physiology
Baylor College of Medicine
Houston, TX US
Addresses
- Office (Office)
-
Taub
T428
Houston, TX 77030
United States
Phone: (713) 798-8666
lagor@bcm.edu
Education
- BS from University of Dallas
- 05/2000 - Irving, Texas USA
- Biochemistry
- PhD from University of South Florida, College of Medicine
- 12/2006 - Tampa, Florida USA
- Post-Doctoral Fellowship at University of Pennsylvania, School of Medicine
- Philadelphia, Pennsylvania USA
Professional Interests
- Lipid and lipoprotein metabolism
- Cardiovascular Sciences
- Gene therapy vectors for the study and treatment of metabolic disease
- Somatic Genome Editing
Professional Statement
My research is focused on the genetics of lipid and lipoprotein metabolism. The goal is to understand how rare and common genetic variation alters metabolic pathways and determines an individual’s susceptibility to disease. Key areas of interest include the related pathologies of atherosclerosis, obesity, type II diabetes, and nonalcoholic liver disease. My laboratory uses a combination of gene targeting and viral vectors for gene delivery to investigate the physiology of lipid metabolism in model organisms, and identify potential new therapeutic targets.Websites
Selected Publications
- Li A, Tanner MR, Lee CM, Hurley AE, De Giorgi M, Jarrett KE, Davis TH, Doerfler AM, Bao G, Beeton C, Lagor WR. "AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9.." Mol Ther.. 2020 Jun 3; Pubmed PMID: 32348718
- Li A, Lee CM, Hurley AE, Jarrett KE, De Giorgi M, Lu W, Balderrama KS, Doerfler AM, Deshmukh H, Ray A, Bao G, Lagor WR. "A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing.." Mol Ther Methods Clin Dev.. 2018 Dec 6; Pubmed PMID: 30619914
- Doerfler AM, Park SH, Assini JM, Youssef A, Saxena L, Yaseen AB, De Giorgi M, Chuecos M, Hurley AE, Li A, Marcovina SM, Bao G, Boffa MB, Koschinsky ML, Lagor WR. "LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study.." Mol Ther Methods Clin Dev.. 2022 Oct 13; Pubmed PMID: 36381302
- Doerfler AM, Han J, Jarrett KE, Tang L, Jain A, Saltzman A, De Giorgi M, Chuecos M, Hurley AE, Li A, Morand P, Ayala C, Goodlett DR, Malovannaya A, Martin JF, de Aguiar Vallim TQ, Shroyer N, Lagor WR. "Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment.." Arterioscler Thromb Vasc Biol.. 2022 Apr; Pubmed PMID: 35172604
- Saha K, Sontheimer EJ, et al. SCGE Consortium "The NIH Somatic Cell Genome Editing program.." Nature. 2021 Apr; Pubmed PMID: 33828315
- Jarrett KE, Lee CM, Yeh YH, Hsu RH, Gupta R, Zhang M, Rodriguez PJ, Lee CS, Gillard BK, Bissig KD, Pownall HJ, Martin JF, Bao G, Lagor WR. "Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease.." Sci Rep.. 2017 Mar 16;(7):44264. Pubmed PMID: 28300165
- Jarrett K.E., Lee C., De Giorgi M., Hurley A., Gillard B.K., Doerfler A.M., Li A., Pownall H.J., Bao G., Lagor W.R. "Somatic editing of Ldlr with Adeno-Associated Viral-CRISPR is an efficient tool for atherosclerosis research." Arterioscler Thromb Vasc Biol.. 2018 Jul 19; Pubmed PMID: 30026278
Memberships
- American Heart Association
- Cardiovascular Research Institute, Baylor College of Medicine
- Member
- Diabetes Research Center, Baylor College of Medicine
- Member
- Digestive Diseases Center, Texas Medical Center
- Associate Member
- American Society for Gene and Cell Therapy
- Member (01/2017)
- American Association for the Study of Liver Diseases
- Member (09/2021)
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