Positions
- Associate Professor
-
Molecular Physiology and Biophysics
Baylor College of Medicine
Houston, TX US
Addresses
- Office (Office)
-
Taub
T428
Houston, TX 77030
United States
Phone: (713) 798-8666
lagor@bcm.edu
Education
- BS from University of Dallas
- 05/2000 - Irving, Texas USA
- Biochemistry
- PhD from University of South Florida, College of Medicine
- 12/2006 - Tampa, Florida USA
- Post-Doctoral Fellowship at University of Pennsylvania, School of Medicine
- Philadelphia, Pennsylvania USA
Professional Interests
- Lipid and lipoprotein metabolism
- Cardiovascular Sciences
- Gene therapy vectors for the study and treatment of metabolic disease
- Somatic Genome Editing
Professional Statement
My research is focused on the genetics of lipid and lipoprotein metabolism. The goal is to understand how rare and common genetic variation alters metabolic pathways and determines an individual’s susceptibility to disease. Key areas of interest include the related pathologies of atherosclerosis, obesity, type II diabetes, and nonalcoholic liver disease. My laboratory uses a combination of gene targeting and viral vectors for gene delivery to investigate the physiology of lipid metabolism in model organisms, and identify potential new therapeutic targets.Websites
Selected Publications
- Jarrett KE, Lee CM, Yeh YH, Hsu RH, Gupta R, Zhang M, Rodriguez PJ, Lee CS, Gillard BK, Bissig KD, Pownall HJ, Martin JF, Bao G, Lagor WR. "Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease.." Sci Rep.. 2017 Mar 16;(7):44264. Pubmed PMID: 28300165
- Pankowicz FP, Jarrett KE, Lagor WR, Bissig KD. "CRISPR/Cas9: at the cutting edge of hepatology.." Gut.. 2017 Jul;66(7):1329-1340. Pubmed PMID: 28487442
- Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL. "A chemical chaperone improves muscle function in mice with a RyR1 mutation.." Nat Commun.. 2017 Mar 24;(8):14659. Pubmed PMID: 28337975
- Palmer E.E. ┼, Jarrett K.E. ┼, Sachdev R.K., Al Zahrani F., Hashem M.O., Ibrahim N., Sampaio H., Kandula T., Macintosh R., <truncated for space>… Kirk E.P., Bye A., Alkuraya F.S., Roscioli T.#, Lagor W.R.#* (┼, # equal contributors, *corresponding) "Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy." Hum. Mol. Genet.. 2016 Jun 6; Pubmed PMID: 27270415
- Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HC, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. "Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.." Nat Commun.. 2015 Jul 17; Pubmed PMID: 26081744
- Lagor W.R., Johnston J.C., Lock M., Vandenberghe L.H., Rader D.J. "Adeno-Associated Viruses as liver directed gene delivery vehicles: focus on lipoprotein metabolism.." Methods Mol. Biol.. 2013 May;1027:273-307. Pubmed PMID: 23912992
- Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL. "Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism.." J Biol Chem.. 2015 Aug 5; Pubmed PMID: 26245899
- Lagor W.R. a, Tong F a, Jarrett K.E., Lin W., Conlon D.M., Smith M., Wang M.Y., Yenilmez B.O., McCoy M.G., Fields D.W., O’Neill S.M., Gupta R., Kumaravel A.K., Redon V., Ahima R.S., Sturley S.L., Billheimer J.T., Rader D.J. (equal contribution) "Deletion of murine Arv1 results in a lean phenotype with increased energy expenditure.." Nutrition and Diabetes. 2015 Oct 19; Pubmed PMID: 26479315
- Gillard B.K., Rodriguez P.J., Fields D.W., Raya J.L., Lagor W.R., Rosales C., Courtney H.S., Gotto A.M. Jr., Pownall H.J. "Streptococcal serum opacity factor promotes cholesterol ester metabolism and bile acid secretion in vitro and in vivo.." Biochim Biophys Acta. 2016 Mar;1861(3):196-204. Pubmed PMID: 26709142
- Kuwano T, Bi X, Cipollari E, Yasuda T, Lagor WR, Szapary HJ, Tohyama J, Millar JS, Billheimer JT, Lyssenko NN, Rader DJ. "Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport.." J Lipid Res.. 2017 Apr;58(4):731-741. Pubmed PMID: 28137768
- Lagor WR, Rader DJ "Phospholipidation of HDL--how much is too much?." Clin. Chem.. 2011 Jan;57(1):41370. Pubmed PMID: 21078838
- Nijstad N, de Boer JF, Lagor WR, Toelle M, Usher D, Annema W, der Giet Mv, Rader DJ, Tietge UJ "Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice.." Biochim. Biophys. Acta. 2011 Apr;1811(4):294-9. Pubmed PMID: 21296681
- Davidson WS, Silva RA, Chantepie S, Lagor WR, Chapman MJ, Kontush A "Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function.." Arterioscler. Thromb. Vasc. Biol.. 2009 Jun;29(6):870-6. Pubmed PMID: 19325143
- Lagor WR, Brown RJ, Toh SA, Millar JS, Fuki IV, de la Llera-Moya M, Yuen T, Rothblat G, Billheimer JT, Rader DJ "Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo.." Arterioscler. Thromb. Vasc. Biol.. 2009 Jan;29(1):40-6. Pubmed PMID: 19008531
- O’Neill S.M., Hinkle C., Chen S.J., Sandhu A., Hovhannisyan R., Stephan S., Lagor W.R., Ahima R.S., Johnston J.C., Reilly M.P. "Targeting adipose tissue via systemic gene therapy." 2014 Jul;21(7):653-661. Pubmed PMID: 24830434
- Niesen MI, Osborne AR, Lagor WR, Zhang H, Kazemfar K, Ness GC, Blanck G "Technological advances in the study of HLA-DRA promoter regulation: extending the functions of CIITA, Oct-1, Rb, and RFX.." Acta Biochim. Biophys. Sin. (Shanghai). 2009 Mar;41(3):198-205. Pubmed PMID: 19280058
- Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez SF, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ "The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.." PLoS ONE. 2012;7(2):e31616. Pubmed PMID: 22363685
- Boone LR, Lagor WR, Moya Mde L, Niesen MI, Rothblat GH, Ness GC "Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter.." Atherosclerosis. 2011 Sep;218(1):77-82. Pubmed PMID: 21605865
- Burkhardt R, Toh SA, Lagor WR, Birkeland A, Levin M, Li X, Robblee M, Fedorov VD, Yamamoto M, Satoh T, Akira S, Kathiresan S, Breslow JL, Rader DJ "Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice.." J. Clin. Invest.. 2010 Dec;120(12):4410-4. Pubmed PMID: 21084752
- Yang Y., Kuwano T., Lagor W.R., Albert C.J., Brenton S., Rader D.J., Brown R.J. "Lipidomic Analyses of Female Mice Lacking Hepatic Lipase and Endothelial Lipase Indicate Selective Modulation of Plasma Lipid Species." 2014 Jun;49(6):505-515. Pubmed PMID: 24777581
- Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ "Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins.." Circ. Res.. 2010 Aug 6;107(3):357-64. Pubmed PMID: 20558822
- Lagor W.R., Fields D.W., Bauer R.C., Crawford A., Abt M.C., Artis D., Wherry E.J., Rader D.J. "Genetic Manipulation of the ApoF/Stat2 locus supports an important role for Type I Interferon signaling in atherosclerosis." 2014 Mar;233(1):234-241. Pubmed PMID: 24529150
- Lagor WR, Heller R, de Groh ED, Ness GC "Functional analysis of the hepatic HMG-CoA reductase promoter by in vivo electroporation.." Exp. Biol. Med. (Maywood). 2007 Mar;232(3):353-61. Pubmed PMID: 17327468
- Lagor WR, de Groh ED, Ness GC "Diabetes alters the occupancy of the hepatic 3-hydroxy-3-methylglutaryl-CoA reductase promoter.." J. Biol. Chem.. 2005 Nov 4;280(44):36601-8. Pubmed PMID: 16127173
- Osborne AR, Pollock VV, Lagor WR, Ness GC "Identification of insulin-responsive regions in the HMG-CoA reductase promoter.." Biochem. Biophys. Res. Commun.. 2004 Jun 11;318(4):814-8. Pubmed PMID: 15147943
- Li. A., Lee C.M., Hurley A.E., Jarrett K.E., De Giorgi M., Lu W., Balderrama K.S., Doerfler A.M., Deshmukh H., Ray A., Bao G.*, Lagor W.R.* "A self-deleting AAV-CRISPR system for in vivo genome editing." Mol Ther Methods Clin Dev. 2018 Dec 6;111-122. Pubmed PMID: 30619914
- Ni L. Scott Jr. L., Campbell H.M., Pan X., Alsina K.M., Reynolds J., Philippen L.E., Hulsurkar M., Lagor W.R., Li N., Wehrens X.H.T. "Atrial-specific gene delivery using an adeno-associated viral vector." Circ. Res. 2018 Nov; Pubmed PMID: 30582449
- Pan X┼., Philippen L.┼, Lahiri S., Lee C., Park S.H., Word T.A., Li N., Jarrett K.E., Gupta R., Reynolds J.O., Lin J., Bao G., Lagor W.R.#, Wehrens X.H.T. "In vivo Ryr2 editing corrects catecholaminergic polymorphic ventricular tachycardia." Circ. Res.. 2018 Sep 28;123(8):953-963. Pubmed PMID: 30355031
- Pankowicz F.P., Barzi M., Kim K.H., Legras X., Martins C.S., Wooton-Kee C.R., Lagor W.R., Marini J.C., Elsea S.H., Bissig-Choisat B., Moore D.D., Bissig K.D. "Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing." Gastroenterology.; Pubmed PMID: 30170115
- Jarrett K.E., Lee C., De Giorgi M., Hurley A., Gillard B.K., Doerfler A.M., Li A., Pownall H.J., Bao G., Lagor W.R. "Somatic editing of Ldlr with Adeno-Associated Viral-CRISPR is an efficient tool for atherosclerosis research." Arterioscler Thromb Vasc Biol.. 2018 Jul 19; Pubmed PMID: 30026278
- Wang C. ┼, He Y. ┼, Xu P. ┼, Yang Y. Saito K., Xia Y., Yan X., Hinton A. Jr., Yan C., Ding H., Yu L., Shu G., Gupta R., Wu Q., Tong Q., Lagor W.R., Flores E.R., Xu Y. "Tap63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis." Nat. Commun.. 2018 Apr 18; Pubmed PMID: 5906443
Memberships
- American Heart Association
- Cardiovascular Research Institute, Baylor College of Medicine
- Member
- Diabetes Research Center, Baylor College of Medicine
- Member
- Digestive Diseases Center, Texas Medical Center
- Associate Member
- American Society for Gene and Cell Therapy
- Member (01/2017)
- American Association for the Study of Liver Diseases
- Member (09/2021)
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