William R. Lagor, Ph.D.

Kyle and Josephine Morrow Endowed Professor

(713) 798-5430

Email

William.Lagor@bcm.edu

Positions

Kyle and Josephine Morrow Endowed Professor: Integrative Physiology
Baylor College of Medicine
Houston, TX, US

Addresses

Office (Office): Taub
T428
Houston, TX, 77030
United States
Phone: (713) 798-8666
lagor@bcm.edu

Education

BS from University of Dallas: 05/2000 - Irving, Texas, USA; Biochemistry

PhD from University of South Florida, College of Medicine: 12/2006 - Tampa, Florida, USA

Post-Doctoral Fellowship at University of Pennsylvania, School of Medicine: Philadelphia, Pennsylvania, USA

Professional Interests

Lipid and lipoprotein metabolism
Cardiovascular Sciences
Gene therapy vectors for the study and treatment of metabolic disease
Somatic Genome Editing

Professional Statement

My research is focused on the genetics of lipid and lipoprotein metabolism. The goal is to understand how rare and common genetic variation alters metabolic pathways and determines an individual’s susceptibility to disease. Key areas of interest include the related pathologies of atherosclerosis, obesity, type II diabetes, and nonalcoholic liver disease. My laboratory uses a combination of gene targeting and viral vectors for gene delivery to investigate the physiology of lipid metabolism in model organisms, and identify potential new therapeutic targets.

Websites

Lagor Lab Web Site

VIICTR - Publications

Selected Publications

Li A, Tanner MR, Lee CM, Hurley AE, De Giorgi M, Jarrett KE, Davis TH, Doerfler AM, Bao G, Beeton C, Lagor WR.. " AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9. " Mol Ther.. 2020 Jun 3;
Pubmed PMID: 32348718.
Li A, Lee CM, Hurley AE, Jarrett KE, De Giorgi M, Lu W, Balderrama KS, Doerfler AM, Deshmukh H, Ray A, Bao G, Lagor WR.. " A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing. " Mol Ther Methods Clin Dev.. 2018 Dec 6;
Pubmed PMID: 30619914.
Doerfler AM, Park SH, Assini JM, Youssef A, Saxena L, Yaseen AB, De Giorgi M, Chuecos M, Hurley AE, Li A, Marcovina SM, Bao G, Boffa MB, Koschinsky ML, Lagor WR.. " LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study. " Mol Ther Methods Clin Dev.. 2022 Oct 13;
Pubmed PMID: 36381302.
Saha K, Sontheimer EJ, et al. SCGE Consortium. " The NIH Somatic Cell Genome Editing program. " Nature. 2021 Apr ;
Pubmed PMID: 33828315.
Jarrett K.E., Lee C., De Giorgi M., Hurley A., Gillard B.K., Doerfler A.M., Li A., Pownall H.J., Bao G., Lagor W.R.. " Somatic editing of Ldlr with Adeno-Associated Viral-CRISPR is an efficient tool for atherosclerosis research " Arterioscler Thromb Vasc Biol.. 2018 Jul 19;
Pubmed PMID: 30026278.

Memberships

American Heart Association

Cardiovascular Research Institute, Baylor College of Medicine: Member

Diabetes Research Center, Baylor College of Medicine: Member

Digestive Diseases Center, Texas Medical Center: Associate Member

American Society for Gene and Cell Therapy: Member (01/2017)

American Association for the Study of Liver Diseases: Member (09/2021)