Wen-Hsiang Chen, Ph.D.
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Wen-Hsiang Chen, Ph.D.
Assistant Professor
Positions
- Assistant Professor
-
Pediatrics-Tropical Medicine
Baylor College of Medicine
Houston, Texas
- Director of Quality Control and Analytical Development
-
Texas Children's Hospital Center for Vaccine Development
Addresses
- 1102 BATES AVE, STE 550, FEIGIN CENTER (Lab)
-
HOUSTON, TX 77030
United States
Education
- BS from National Taiwan University
- Taipei, Taiwan
- Chemical Engineering
- PhD from University of Houston
- Houston, Texas United States
- Chemical Engineering
Professional Interests
- Vaccine
- Quality Control
- Gene cloning and expressing
- Biotechnology
- Protein purification
- Upstream Process-Fermentation
- Analytical Development
Websites
Selected Publications
- S Dhamane, F Ruiz-Ruiz, WH Chen, K Kourentzi, J Benavides, M Rito-Palomares, RC Willson. "Spermine Sepharose as a Clustered-Charge Anion Exchange Adsorbent.." J Chromatogr A. 2014 January ; :
- L Kisley, J Chen, AP Mansur, B Shuang, K Kourentzi, MV Poongavanam, WH Chen, S Dhamane, RC Willson, CF Landes "Unified super-resolution experiments and stochastic theory provide mechanistic insight into protein ion-exchange adsorptive separations.." PNAS. 2014 January ; :
- WH Chen+, L Du+, SM Chag, C Ma, N Tricoche, X Tao, CA Seid, EM Hudspeth, S Lustigman, CK Tseng, ME Bottazzi, PJ Hotez, B Zhan, S Jiang. "Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate.." Hum Vaccin Immunother. 2013 December ; :
- WH Chen, MP Nyon, MV Poongavanam, Z Liu, AB Biter, RT Kundu, U Strych, PJ Hotez, ME Bottazzi "Process Characterization and Biophysical Analysis for a Yeast-expressed Phlebotomus papatasi Salivary Protein (PpSP15) as a Leishmania vaccine candidate." J Pharm Sci.. 2020 February 15; : Pubmed PMID: 32070701
- WH Chen, U Strych, PJ Hotez, ME Bottazzi "The SARS-CoV-2 Vaccine Pipeline: an Overview." Curr. Trop. Med. Rep.. 2020 March 3; :
- Marcinkiewicz AL, Lieknina I, Yang X, Lederman PL, Hart TM, Yates J, Chen WH, Bottazzi ME, Mantis NJ, Kraiczy P, Pal U, Tars K, Lin YP. "The Factor H-binding site of CspZ as a protective target against multi-strain, tick-transmitted Lyme disease." Infection and immunity. 2020 March ; : Pubmed PMID: 32122944
- AB Biter, J Pollet, WH Chen, U Strych, PJ Hotez, ME Bottazzi "A method to probe protein structure from UV absorbance spectra." Anal Biochem. 2019 December 15; : Pubmed PMID: 31550438
- I Kanakaraj, WH Chen, M Poongavanam, S Dhamane, LJ Stagg, JE Ladbury, K Kourentzi, U Strych, RC Willson. "Biophysical characterization of VEGF-aHt DNA aptamer interactions.." Int J Biol Macromol. 2013 March ; :
- AB Biter, S Weltje, EM Hudspeth, CA Seid, CP McAtee, WH Chen, JB Pollet, U Strych, PJ Hotez, ME Bottazzi "Characterization and Stability of Trypanosoma cruzi 24-C4 (Tc24-C4), a Candidate Antigen for a Therapeutic Vaccine Against Chagas Disease." J Pharm Sci. 2018 May ; 107 (5): 1468-1473. Pubmed PMID: 29274820
- M Adhikari, S Dhamane, AEV Hagström, G Garvey, WH Chen, K Kourentzi, U Strych, RC Willson. "Functionalized viral nanoparticles as ultrasensitive reporters in lateral-flow assays.." Analyst. 2013 July ; :
- CR Daniels, L Kisley, H Kim, WH Chen, MV Poongavanam, C Reznik, K Kourentzi, RC Willson, CF Landes. "Fluorescence correlation spectroscopy study of protein transport and dynamic interactions with clustered-charge peptide adsorbents." J Mol Recognit. 2012 August ; :
- WH Chen, JY Fu, K Kourentzi, RC Willson "Nucleic acid affinity of clustered-charge anion exchange adsorbents: effects of ionic strength and ligand density." J Chromatogr A. 2011 January ; :
- WH Chen, SM Chag, MV Poongavanam, AB Biter, EA Ewere, W Rezende, CA Seid, EM Hudspeth, J Pollet, CP McAtee, U Strych, ME Bottazzi, PJ Hotez "Optimization of the Production Process and Characterization of the Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1), a SARS Vaccine Candidate." J Pharm Sci. 2017 April ; : Pubmed PMID: 28456726
- CR Daniels, C Reznik, R Kilmer, MJ Felipe, MC Tria, K Kourentzi, WH Chen, RC Advincula, RC Willson, CF Landes "Permeability of anti-fouling PEGylated surfaces probed by fluorescence correlation spectroscopy." Colloids Surf B Biointerfaces. 2011 November ; :
- WH Chen, PJ Hotez, ME Bottazzi "Potential for Developing a SARS-CoV Receptor-Binding Domain (RBD) Recombinant Protein as a Heterologous Human Vaccine Against Coronavirus Infectious Disease (COVID)-19." Hum Vaccin Immunother. 2020 April 16; : Pubmed PMID: 32298218
- WH Chen, X Tao, AS Agrawal, A Algaissi, BH Peng, J Pollet, U Strych, ME Bottazzi, PJ Hotez, S Lustigman, L Du, S Jiang, CK Tseng "Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement." Vaccine. 2020 September ; : Pubmed PMID: 33039209
- Z Liu, R Kundu, S Damena, AB Biter, MP Nyon, W-H Chen, B Zhan, U Strych, PJ. Hotez, ME Bottazzi "A scalable and reproducible manufacturing process for Phlebotomus papatasi salivary protein PpSP15, a vaccine candidate for leishmaniasis." Protein Expr Purif. 2020 September ; : Pubmed PMID: 32920041
Projects
- RBD RECOMBINANT PROTEIN-BASED SARS VACCINE FOR BIODEFENSE
- Coronavirus vaccines
- https://www.bcm.edu/departments/pediatrics/sections-divisions-centers/tropical-medicine/research/vaccine-development/coronavirus-vaccines
Memberships
- American Society of Microbiology
- Member
- American Chemical Society
- Former Member
Intellectual Property
- A novel SARS immunogenic composition
- Product Patent #US20160376321A1 (Approved)
- Co Inventors: PJ Hotez, ME Bottazzi, B Zhan, W-H Chen,SM Chag
Languages
Manderin Chinese, Taiwanese
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