Email

slee@bcm.edu

Positions

Associate Professor

Biochemistry-Tsai Lab
Baylor College of Medicine
Houston, TX, US

Managing Director

X-ray Crystallography Facility
Baylor College of Medicine
Houston, Texas, United States

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

Baylor College of Medicine (Office)

BCM-Cullen Building
Room: BCMC-371A1
Houston, TX 77030-3498
United States
(713) 798-4390
slee@bcm.edu

Education

Post-Doctoral Fellowship at Yale University

10/2000 - New Haven, Connecticut, United States

Molecular Biophysics and Biochemistry

Post-Doctoral Fellowship at Purdue University

03/1998 - West Lafayette, Indiana, United States

Biological Sciences

PhD from Purdue University

08/1997 - West Lafayette, Indiana, United States

Biological Sciences

MS from Seoul National University

02/1991 - Seoul, Korea

Chemistry

BS from Seoul National University

02/1989 - Seoul, Korea

Chemistry

Honors & Awards

Beginning Grant-in-Aid Award

American Heart Association Texas Affiliate

New Investigator Award

Department of Defense

International Union of Crystallography Young Scientist Travel Grant

International Union of Crystallography

Korean Government Overseas Scholarship

Korean Government

Frederick N. Andrews Doctoral Fellowship

Purdue University

Undergraduate Scholarship

Korea Scholarship Foundation for Future Leaders

Professional Interests

• Antibiotic Resistance
• Cryo-electron Microscopy and Tomography
• Membranes and Membrane Proteins
• Nano Medicine and Drug Design
• Protein Structure Function and Protein Folding
• Structural Biology and Macromolecular Assemblies by Organism
• Bacteria and Phage
• Human
• Yeast and Dicty

Professional Statement

Mitochondrial Proteostasis Maintenance
The broad and long-term research objective of my laboratory is to provide a molecular understanding of the protein quality control machinery that maintains mitochondrial proteostasis. On-going research focuses on determining the structure, function, and mechanism of molecular chaperones, membrane-associated proteases, kinases and enzymes using a multi-pronged approach combining X-ray crystallography and cryoEM/cryoET with biochemical, biophysical, and functional studies. The goal of our research is to provide a detailed mechanistic understanding of mitochondrial quality control proteins in order to exploit this information for rationale structure-based drug development.

Websites

Selected Publications

• Lee, J., Kim, J.-H., Biter, A.B., Sielaff, B., Lee, S.* and Tsai, F.T.F "Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor." Proc Natl Acad Sci. 2013 May 21; 110 : 8513-8518. Pubmed PMID: 23650362
• Biter, A.B., Lee, S., Sung, N. and Tsai, F.T.F "Structural basis for inter-subunit signaling in a protein disaggregating machine." Proc Natl Acad Sci. 2012 July 31; 109 (31): 12515-20. Pubmed PMID: 22802670
• Biter, A.B., Lee, J., Sung, N., Tsai, F.T.F. and Lee, S "Functional analysis of conserved cis- and trans-elements in the Hsp104 protein disaggregating machine." J. Structural Biol. 2012 August ; 179 (2): 172-80. Pubmed PMID: 22634726
• Lee, S.*, Augustin, S., Tatsuta, T., Gerdes, F., Langer, T. and Tsai, F.T.F "Electron cryomicroscopy structure of a membrane-anchored mitochondrial AAA protease." J. Biol. Chem. 2011 February 11; 286 (6): 4404-4411. Pubmed PMID: 21147776

Memberships

American Crystallography Association

Member

American Association for the Advancement of Science

Member