Sanjeev Ayyangar Vasudevan, M.D.
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Positions
- Professor of Surgery
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Division of Pediatric Surgery
Baylor College of Medicine
- Attending Surgeon, Pediatric Surgery Service
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Texas Children's Hospital
- Program Director, General Surgery Residency - Research Track
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Baylor College of Medicine
Addresses
- Texas Children's Hospital (Clinic)
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Clinical Care Center
6701 Fannin Street
Houston, TX 77030
United States
Phone: (832) 822-3135
Pediatric Surgery
Education
- B.S. from Emory University
- 01/1997 - Atlanta, GA United States
- B.A. from Emory University
- 01/1997 - Atlanta, GA United States
- General Surgery Residency from Baylor College Of Medicine
- 01/2009 - Houston, TX United States
- M.D. from Emory University School Of Medicine
- 01/2001 - Atlanta, GA United States
- Pediatric Surgery Residency from Baylor College Of Medicine
- 01/2011 - Houston, TX United States
Certifications
- Board Certified - Pediatric Surgery
- American Board of Surgery
- Board Certified - General Surgery
- American Board of Surgery
Honors & Awards
- Norton Rose Fulbright Faculty Excellence Award for Teaching & Evaluation
- Baylor College of Medicine
- 2020 Top Doctor: Pediatric Surgery
- Houstonia Magazine
- Michael E. DeBakey Distinguished Service Award
- Michael E. DeBakey Department of Surgery
Professional Interests
- Pediatric surgical oncology
- Neuroblastoma
Professional Statement
Dr. Sanjeev A. Vasudevan is committed to providing the finest patient-oriented pediatric surgical care with special attention to the surgical needs of children with cancer and the needs of their families. This dedication combines education and training, advanced research, and the development of newer and better treatments and procedures. Dr. Vasudevan’s laboratory research focuses on the validation of potential therapeutic targets found in pediatric solid tumors and cancer, in particular neuroblastoma. During his postdoctoral training in the Texas Children’s Cancer Center with Drs. Jed G. Nuchtern and Jianhua Yang, Dr. Vasudevan cloned two novel genes, NDSP and DUSP26, which were found to be specifically expressed in neuroblastoma and play critical roles in neuroblastoma tumor growth and chemosensitivity. Dr. Vasudevan is furthering this work as the principal investigator of a research project that focuses on the function and regulation of both the p53 and MYCN pathways in neuroblastoma. His lab uses techniques such as retroviral-induced shRNA inhibition of protein expression, real-time PCR, chromatin immunoprecipitation, recombinant protein purification, in vitro proliferation and cytotoxicity assays, orthotopic mouse models of neuroblastoma, and in vivo bioluminescence imaging for molecular target validation. Dr. Vasudevan’s lab research hopes to validate multiple targets in order to find novel and less toxic therapeutic agents to improve outcomes in neuroblastoma.Websites
Texas Children's Hospital
Pediatric Surgical Oncology Laboratory
Videos
Selected Publications
- Vasudevan SA, Shang X, Chang S, Ge N, Diaz-Miron JL, Russell HV, Hicks MJ, Ludwig AD, Wesson CL, Burlingame SM, Kim ES, Khan J, Yang J, Nuchtern JG "Neuroblastoma-derived secretory protein is a novel secreted factor overexpressed in neuroblastoma.." Mol. Cancer Ther.. 2009 Aug;8(8):2478-89. Pubmed PMID: 19671756
- Hassan SF, Mathur S, Magliaro TJ, Larimer EL, Ferrell LB, Vasudevan SA, Patterson DM, Louis CU, Russell HV, Nuchtern JG, Kim ES "Needle core vs open biopsy for diagnosis of intermediate- and high-risk neuroblastoma in children.." J. Pediatr. Surg.. 2012 Jun;47(6):1261-6. Pubmed PMID: 22703803
- Fallon SC, Redell MS, El-Bietar J, Lopez ME, Vasudevan SA, Brandt ML "Intestinal perforation after treatment of Burkitt's lymphoma: Case report and review of the literature.." J. Pediatr. Surg.. 2013 Feb;48(2):436-40. Pubmed PMID: 23414881
- Wulkan ML, Vasudevan SA "Is end-tidal CO2 an accurate measure of arterial CO2 during laparoscopic procedures in children and neonates with cyanotic congenital heart disease?." J. Pediatr. Surg.. 2001 Aug;36(8):1234-6. Pubmed PMID: 11479864
- Shang X, Burlingame SM, Okcu MF, Ge N, Russell HV, Egler RA, David RD, Vasudevan SA, Yang J, Nuchtern JG "Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma.." Mol. Cancer Ther.. 2009 Aug;8(8):2461-9. Pubmed PMID: 19671766
- Vasudevan SA, Nuchtern JG, Shohet JM "Gene profiling of high risk neuroblastoma.." World J Surg. 2005 Mar;29(3):317-24. Pubmed PMID: 15706435
- Vasudevan SA, Kerendi F, Lee H, Ricketts RR "Management of congenital esophageal stenosis.." J. Pediatr. Surg.. 2002 Jul;37(7):1024-6. Pubmed PMID: 12077763
- Vasudevan SA, Russell HV, Okcu MF, Burlingame SM, Liu ZJ, Yang J, Nuchtern JG "Neuroblastoma-derived secretory protein messenger RNA levels correlate with high-risk neuroblastoma.." J. Pediatr. Surg.. 2007 Jan;42(1):148-52. Pubmed PMID: 17208556
- Rojas Y, Warneke CL, Dhamne CA, Tsao K, Nuchtern JG, Lally KP, Vasudevan SA, Hayes-Jordan AA, Cass DL, Herzog CE, Hicks MJ, Kim ES, Austin MT "Primary malignant pancreatic neoplasms in children and adolescents: A 20year experience.." J. Pediatr. Surg.. 2012 Dec;47(12):2199-204. Pubmed PMID: 23217876
- Shang X, Vasudevan SA, Yu Y, Ge N, Ludwig AD, Wesson CL, Wang K, Burlingame SM, Zhao YJ, Rao PH, Lu X, Russell HV, Okcu MF, Hicks MJ, Shohet JM, Donehower LA, Nuchtern JG, Yang J "Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma.." Oncogene. 2010 Sep 2;29(35):4938-46. Pubmed PMID: 20562916
- Vasudevan SA, Skoko J, Wang K, Burlingame SM, Patel PN, Lazo JS, Nuchtern JG, Yang J "MKP-8, a novel MAPK phosphatase that inhibits p38 kinase.." Biochem. Biophys. Res. Commun.. 2005 May 6;330(2):511-8. Pubmed PMID: 15796912
- Mathur S, Vasudevan SA, Patterson DM, Hassan SF, Kim ES "Novel use of glycopyrrolate (Robinul) in the treatment of anastomotic leak after repair of esophageal atresia and tracheoesophageal fistula.." J. Pediatr. Surg.. 2011 Mar;46(3):e29-32. Pubmed PMID: 21376184
- Vasudevan SA, Cumbie TA, Dishop MK, Nuchtern JG "Retroperitoneal hemangioma of infancy.." J. Pediatr. Surg.. 2006 Jan;41(1):e41-4. Pubmed PMID: 16410088
- Vasudevan SA, Patel JC, Wesson DE, Plon SE, Finegold MJ, Nuchtern JG "Severe dysplasia in children with familial adenomatous polyposis: rare or simply overlooked?." J. Pediatr. Surg.. 2006 Apr;41(4):658-61. Pubmed PMID: 16567172
Memberships
- American Association for Cancer Research
- American College of Surgeons
- Phi Beta Kappa
- Society of University Surgeons
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