Rajat Bhattacharya, Ph.D.

Faculty

Email

rajat.bhattacharya@bcm.edu

Positions

Faculty: Division of Surgical Oncology
Baylor College of Medicine

Addresses

Baylor College of Medicine (Lab): Alkek Building for Biomedical Research
R431B
Houston, TX, 77030
United States

Education

PhD from University of Calcutta: West Bengal, India

MSc from University of Calcutta: West Bengal, India

BSc from University of Calcutta: West Bengal, India

Research Fellowship at Baylor College of Medicine: Houston, Texas, United States; RNA biology

Professional Interests

GI Oncology Translational Research
Combinatorial Therapeutic Strategies
GI Malignancies
Endothelial Cell Biology

Professional Statement

Dr. Rajat Bhattacharya is a faculty member in the Michael E. DeBakey Department of Surgery at Baylor College of Medicine. His major research interests are focused on understanding mechanisms of resistance to therapies and developing novel strategies to overcome failure of systemic therapeutics in gastrointestinal (GI) malignancies with a focus on colorectal cancer (CRC). Another area of focus is in understanding the role of the tumor microenvironment and therapeutic interventions on immune modulation in CRC and other GI tumors. Dr. Bhattacharya’s research program integrates tumor biology, high-throughput combinatorial drug discovery and preclinical animal models with the goal of improving outcomes in patients with GI malignancies.

Websites

Division of Surgical Oncology

Selected Publications

Ghosh, S, Fan, F, Powell, RT, Park, YS, Stephan, C, Kopetz, ES, Ellis, LM, Bhattacharya, R.. " Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer " Therapeutic Advances in Medical Oncology. ;
Chattopadhyay C, Roszik J, Bhattacharya R, Alauddin M, Mahmud I, Yadugiri S, Ali MM, Khan FS, Prabhu VV, Lorenzi PL, Wei B, Burton E, Morey RR, Lazcano R, Davies MA, Patel SP, Grimm EA. " Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma " Br J Cancer. ;
Pubmed PMID: 39394450.
Ghosh S, Fan F, Powell RT, Roszik J, Park YS, Stephan C, Sebastian M, Tan L, Sorokin AV, Lorenzi PL, Kopetz S, Ellis LM, Bhattacharya R. " Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer " Mol Cancer Ther. ;
Pubmed PMID: 37310170.
Fan F, Ghosh S, Powell R, Roszik J, Park Y, Sobieski M, Sorokin A, Stephan C, Kopetz S, Ellis LM, Bhattacharya R. " Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo " PLoS One. ;
Pubmed PMID: 36952536.
Rathore M, Zhang W, Wright M, Bhattacharya R, Fan F, Vaziri-Gohar A, Winter J, Wang Z, Markowitz SD, Willis J, Ellis LM, Wang R. " Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS " Mol Cancer Res. ;
Pubmed PMID: 35276002.
Fan F, Roszik J, Xia L, Ghosh S, Wang R, Ye X, Hawke D, Ellis LM, Bhattacharya R. " Cytospin-A Regulates Colorectal Cancer Cell Division and Migration by Modulating Stability of Microtubules and Actin Filaments " Cancers (Basel). ;
Pubmed PMID: 35454887.
Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. " A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics " Int J Cancer. ;
Pubmed PMID: 31472018.
Wang R, Bhattacharya R, Ye X, Fan F, Boulbes DR, Ellis LM. " Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion " Mol Cancer Res. ;
Pubmed PMID: 30131447.
Bhattacharya R, Ellis LM. " It Is Time to Re-evaluate the Peer Review Process for Preclinical Research " Bioessays. ;
Pubmed PMID: 29226979.