Fong
Middle Name
Wilson
Lam, M.D., F.A.A.P.
Middle Name
Wilson
Picture

Fong
Middle Name
Wilson
Lam, M.D., F.A.A.P.
Middle Name
Wilson
Associate Professor
Positions
- Associate Professor
-
Pediatrics-Critical Care
Baylor College of Medicine
Houston, TX US
- WOC
-
Center for Translational Research on Inflammatory Diseases
Michael E. DeBakey Veterans Affairs Medical Center
Addresses
- Center for Translational Research on Inflammatory Diseases (Lab)
-
Michael E. DeBakey VA Medical Center
2002 Holcombe Blvd. (MS 151)
Houston, TX 77030
United States
Phone: (713) 791-1414
flam@bcm.edu
- Texas Children’s Hospital (Clinic)
-
6651 Main Street
Legacy Tower
Houston, TX 77030
United States
Phone: (832) 826-6230
flam@bcm.edu
Education
- MD from University Of Texas Southwestern Medical School
- 01/2003 - Dallas, TX United States
- BA from University of Texas
- Austin, Texas United States
- Internship at Baylor College of Medicine
- Houston, TX
- Pediatrics
- Residency at Baylor College of Medicine
- Houston, TX
- Pediatrics
- Fellowship at Baylor College of Medicine
- Houston, TX
- Pediatric Critical Care Medicine
Certifications
- General Pediatrics
- American Academy of Pediatrics
- General Pediatrics
- Pediatric Critical Care Medicine
- American Academy of Pediatrics
- Subspecialty: Critical Care Medicine
Professional Interests
- Neutrophil-platelet-endothelial interactions in inflammation and thrombosis
Professional Statement
RESEARCH: My research interests are in the complex interplay between neutrophils, platelets, and endothelium and how these interactions mediate inflammation and thrombosis. I have focused my research on platelet-neutrophil-endothelial interactions in order to determine novel mechanisms on how these cells interact in different models of inflammation (sepsis, wound injury, and toxin mediated hepatotoxicity and fibrosis). In this current climate of the SARS-CoV-2 pandemic, research into mechanisms and potential therapies are paramount. As a pediatric intensivist and a member of the Special Isolation Unit at Texas Children’s Hospital, I have a clinical interest in this disease. In our laboratory, we are creating and testing novel compounds to prevent SARS-CoV-2 attachment and inflammation. My laboratory is in the Center for Translation Research on Inflammatory Diseases (CTRID) at the Michael E. DeBakey Veterans Affairs Medical Center, where I actively collaborate with experts in the field of platelet biology, vascular biology, and inflammation. In addition to working with other BCM investigators, I also have developed research collaborations with investigators at the McGovern Medical School (UT Health Sciences Center) and the University of Houston.CLINICAL: I have many clinical interests revolving around the physiology of critically ill children. One of these interests is in severe sepsis and the interplay between thrombosis and inflammation, where dysregulation of one can lead to dysfunction in the other and both can alter tissue perfusion and lead to organ injury. Additionally, I am a founding member of the Texas Children’s Hospital Liver ICU team, caring for critically ill patients with acute and acute-on-chronic liver failure. Caring for children with liver disease has been a rewarding experience in terms of both the complex physiology as well as the multi-disciplinary teamwork involved in treating them.
EDUCATION: In critical care, understanding the core concepts of normal and abnormal physiology is paramount to the appropriate care of severely ill and injured children. To this end, I have developed our Core and Applied Physiology Curriculum which spans ~23 sessions over the course of the year. I have an interest in effective education and have developed this program with the input of our fellows. We utilize a flipped-classroom approach, combined with peer teaching and small group discussions to allow for a safe, but effective learning environment. Finally, I am passionate about training the next generation of pediatrician-scientists and am the Deputy Director for Scholarly Activities in the Division of Pediatric Critical Care Medicine. I am also on the Advisory Board of the Texas Children's Hospital Pediatric Scientist Program.
Websites
Selected Publications
- 1. Valladolid C, Martinez-Vargas M, Sekhar N, Lam F, Brown C, Palzkill T, Tischer A, Auton M, Vijayan KV, Rumbaut RE, Nguyen TC, Cruz MA. "Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation.." Blood Adv. 2020 Apr;14(4(7)):1340-1349. Pubmed PMID: 32259201
- 2. Gorgis NM, Kennedy C, Lam F, Thompson K, Coss-Bu J, Akcan Arikan A, Nguyen T, Hosek K, Miloh T, Karpen SJ, Penny DJ, Goss J, Desai MS. "Clinical Consequences of Cardiomyopathy in Children With Biliary Atresia Requiring Liver Transplantation.." Hepatology. 2019 Mar;69((3)):1206-1218. Pubmed PMID: 30076624
- 3. Lam FW, Da Q, Guillory B, Cruz MA. "Recombinant human vimentin binds to P-selectin and blocks neutrophil capture and rolling on platelets and endothelium.." J Immunol. 2018 Mar 1;200((5)):1718-1726. Pubmed PMID: 29335256
- 4. Goldman J, Desai MS, McClain KL, Tcharmtchi MH, Kennedy CE, Thompson K, Lam F, Bashir DA, Chinn IK, Goldberg BR, Allen CE, Nguyen TC. "Hepatobiliary Dysfunction and Disseminated Intravascular Coagulation Increase Risk of Mortality in Pediatric Hemophagocytic Lymphohistiocytosis." Pediatr Crit Care Med. 2018 Oct;19((10)):e522-e530. Pubmed PMID: 30113519
- Fong W Lam, Miguel A Cruz, Kathan Parikh, Rolando E Rumbaut "Histones stimulate von Willebrand factor release in vitro and in vivo." Haematologica. 2016 Mar Pubmed PMID: 27013650
- Lam FW, Vijayan KV, Rumbaut RE "Platelets and their interactions with other immune cells." Compr Physiol. 2015;5(3):1265-1280. Pubmed PMID: 26140718
- Lam FW, Brown CA, Valladolid C, Emebo DC, Palzkill TG, Cruz MA "The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium." PLOS ONE. 2020 Pubmed PMID: 33099176
- Lam FW, Rumbaut RE "Platelets mediate acetaminophen hepatotoxicity." Blood. 2015;126(15):1738-9. Pubmed PMID: 26450954
- Lam FW, Burns AR, Smith CW, Rumbaut RE "Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1.." Am. J. Physiol. Heart Circ. Physiol. 2011 Feb;300(2):H468-75. Pubmed PMID: 21169400
- Patel KN, Soubra SH, Lam FW, Rodriguez MA, Rumbaut RE "Polymicrobial sepsis and endotoxemia promote microvascular thrombosis via distinct mechanisms.." J. Thromb. Haemost. 2010 Jun;8(6):1403-9. Pubmed PMID: 20345726
- Lam FW, Philips J, Landry P, Smith CW, Rumbaut RE, Burns AR "Platelet recruitment promotes keratocyte repopulation following corneal epithelial abrasion in the mouse.." PLOS ONE. 2015 Mar;10(3):e0118950. Pubmed PMID: 25775402
- Lam FW, Rumbaut RE, Burns AR "Mechanisms of Neutrophil Migration." The Neutrophils: New Outlook for Old Cells, 3. 2013:129-188.
- Desai MS, Shabier Z, Taylor M, Lam F, Thevananther S, Kosters A, Karpen SJ "Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis.." Hepatology. 2010 Jun;51(6):2097-107. Pubmed PMID: 20512997
- Lam FW, Cruz MA, Leung HE, Parikh KS, Smith CW, Rumbaut RE "Histone induced platelet aggregation is inhibited by normal albumin." Thrombosis Research. 2013;132(1):69-76. Pubmed PMID: 23673386
- Stark RJ, Naik-Mathuria BJ, Lam FW, Olutoye OO, Sutton VR, Shekerdemian LS "Extracorporeal membrane oxygenation support of a severe metabolic crisis in a child with methylmalonic acidemia.." ASAIO J. 2012 Jul;58(4):438-9. Pubmed PMID: 22711065
- Nguyen T, Kyle UG, Jaimon N, Tcharmtchi MH, Coss-Bu JA, Lam F, Teruya J, Loftis L "Coinfection with Staphylococcus aureus increases risk of severe coagulopathy in critically ill children with influenza A (H1N1) virus infection.." Crit. Care Med. 2012 Dec;40(12):3246-50. Pubmed PMID: 22971587
- Shan Z, Li L, Atkins CL, Wang M, Wen Y, Jeong J, Moreno NF, Feng D, Gui X, Zhang N, Lee CG, Elias JA, Lee WM, Gao B, Lam FW, An Z, Ju C "Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment." Elife. 2021 Pubmed PMID: 34110284
- Mendelson AA, Lam F, Peirce SM, Murfee WL "Clinical perspectives on the microcirculation." Microcirculation. 2021 Pubmed PMID: 33629399
Memberships
- American Academy of Pediatrics
- Society of Critical Care Medicine
- Microcirculatory Society
- American Heart Association
- American Physiological Society
Funding
- Utilizing soluble vimentin and its components to attenuate inflammation - #GM123261 (04/01/2017 - 03/31/2022) Grant funding from NIH/NIGMS K08 (PI)
- The goal of this study is to determine the mechanisms through which recombinant vimentin attenuates inflammation and to identify the active motifs through which its interactions occur.
- Role of Chitinase-3-like-1 (Chi3l1) in Acetaminophen-induced Liver Injury - #DK122708 (09/19/2019 - 08/31/2024) Grant funding from NIH/NIDDK R01 (Co-Investigator)
- The goal of this proposal is to define the role of chitinase-3-like-1 (Chi3l1) in hepatic platelet accumulation during acetaminophen (APAP)-induced liver injury (AILI) and to evaluate the potential of targeting Chi3l1 for the treatment of AILI.
- Platelets in APAP-Induced Hepatotoxicity (01/01/2020 - 12/31/2020) Grant funding from Texas Medical Center Digestive Diseases Core Pilot Award (PI)
- The objective of this research is to determine the role of platelets in the progression of APAP-induced liver injury as well as test novel agents to mitigate liver damage.
- Enabling Pediatric Leukapheresis with High-Throughput Microfluidic Technology - #HL151858 (04/01/2020 - 03/31/2024) Grant funding from NIH/NHLBI R01 (Co-Investigator)
- The goal of this proposal is the development and initial validation of novel microfluidic devices capable of separating white blood cells from whole blood with efficiency and throughput sufficiently high to ultimately enable centrifugation-free leukapheresis in pediatric patients.
- Using rhRod to block SARS-CoV-2 viral adhesion and infection (10/01/2020 - 09/30/2021) Grant funding from Michael E. DeBakey Veterans Affairs Medical Center
- The goal of this proposal is to test the efficacy of rhRod on blocking SARS-CoV-2 viral adhesion and infection using in vitro cell cultures.
Skills
- Neutrophil biology
- Critical Care Medicine
- Platelet biology
- Endothelial biology
- Intravital microscopy
- Microvascular inflammation and thrombosis
Log In to edit your profile