Alexis Wood, Ph.D, F.A.H.A.
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Alexis Wood, Ph.D, F.A.H.A.
Associate Professor
Positions
- Associate Professor
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Pediatrics-Nutrition
Baylor College of Medicine
Houston, TX US
Addresses
- Children's Nutrition Research Center (Office)
-
Room: CNRC-2036
Houston, TX 77030
United States
Phone: (713) 798-7055
Education
- BS from University of Warwick
- 06/2002 - Coventry, United Kingdom
- Psychology and Philosophy
- MS from Kings College London
- 10/2006 - London
- Social, Genetic and Developmental Psychiatry
- PhD from Kings College London
- 10/2009 - London
- Social, Genetic and Developmental Psychiatry
- Post-Doctoral Fellowship at University of Alabama at Birmingham
- 06/2012 - Birmingham, Alabama
- Statistical Genetics, Epidemiology
Honors & Awards
- Conference Award Finalist
- MD Anderson Energy Balance Retreat (02/2014)
- Scott Grundy Award for Excellence in Metabolism Research
- American Heart Association (03/2013)
- 2nd place
- UAB Annual Postdoctoral Research Day (02/2012)
- 1st Place
- NORC “Creativity is Decision" (06/2011)
- 1st Place
- Center for Cardiovascular Disease Biology Annual Retreat (05/2011)
- 2nd place
- Center for Cardiovascular Disease Biology Annual Retreat (05/2011)
- 1st Place
- SOPH 3rd Annual Public Health Research day (04/2011)
- Young Investigator Award Finalist
- American Heart Association EPI/NPAM conference (03/2011)
- Young Investigator Award
- 2nd Annual International Congress on ADHD (05/2009)
- Best paper winner
- Our paper "Cognitive performance and BMI: shared genetics between BMI and reaction time, but not response inhibition, across childhood" was selected as one of 6 winning entries to the society's annual conference and featured in a special symposium.
- The Obesity Society (11/2014)
- Associate Faculty Member F1000 Prime
- Appointed an Associate Faculty Member of the Faculty of 1000 http://f1000.com/
- F1000 Prime (09/2014)
- Mark Bieber Award for Excellence in Nutrition Research
- American Heart Association (03/2015)
- Fellow of The American Heart Association
- 09/2017
- Young Investigator Award
- Baylor College of Medicine -- Department of Pediatrics (12/2020)
- Top abstract
- CVRI annual conference (04/2017)
Professional Statement
My research focuses on analyzing complex biological data such as genome, epigenome, transcriptome, metabolome, and proteome to explore how environmental and behavioral factors influence chronic diseases. I am particularly interested in cognitive development and decline, including Alzheimer's Disease and related dementias (ADRD), as well as type 2 diabetes (T2D). My overarching aim is to advance Precision Medicine by improving disease prevention, diagnosis, and treatment strategies.Websites
Selected Publications
- "The need for greater rigor in childhood nutrition and obesity research." JAMA Peds. 2019;173(4):311-2.
- Djonlagic I, Mariani S, Fitzpatrick AL, Van Der Klei VMGTH, Johnson DA, Wood AC, et al "Macro and micro sleep architecture and cognitive performance in older adults." Nat Hum Behav. 2021;5(1) Pubmed PMID: 33199858
- Wood AC, Blissett JM, Brunstrom JM, Carnell S, Faith MS, Fisher JO, Hayman LL, Khalsa AS, Hughes SO, Miller AL, Momin SR, Welsh JA, Woo JG, Haycraft E "Caregiver influences on eating behaviors in young children: A scientific statement from the American Heart Association." J Am Heart Assoc. 2020;9(10) Pubmed PMID: 32389066
- Wood, A. C., Graca, G., Gadgil, M., Senn, M. K., Allison, M. A., Tzoulaki, I., ... & Herrington, D. (2023). "Untargeted metabolomic analysis investigating links between unprocessed red meat intake and markers of inflammation." AJCN. 2023;13(3):989-999. Pubmed PMID: 37660929
- Wood, A. C., Goodarzi, M. O., Senn, M. K., Gadgil, M. D., Graca, G., Allison, M. A., ... & Rotter, J. I. "Associations between Metabolomic Biomarkers of Avocado Intake and Glycemia in the Multi-Ethnic Study of Atherosclerosis." Jnl Nutr.;153(10):2797-2807. Pubmed PMID: 37562669
- Xiao, S., Li, V. L., Lyu, X., Chen, X., Wei, W., Abbasi, F., ... & Long, J. Z. (2024) "Lac-Phe mediates the effects of metformin on food intake and body weight." Nat Metab. 2024;64(4):659-669. Pubmed PMID: 38499766
- Marrero, N., Jha, K., Hughes, T. M., Razavi, A. C., Grant, J. K., Boakye, E., ... & Whelton, S. P. "Association of aortic valve calcium with dementia and stroke: The Multi-Ethnic Study of Atherosclerosis." Atherosclerosis. 2024; Pubmed PMID: 38890039
Memberships
- American Heart Association
- American Society of Nutrition
Funding
- Longitudinal associations of preschoolers’ technology and digital media (TDM) use and executive functioning: a mechanism linking TDM with young children’s weight status - #NIH P01 HD109876
- ( 09/09/2022 - 09/08/2027 ) Grant funding from NIH
- Role: MPI (Wood, Hughes & Bridgett).
- Molecular Markers of Beef Intake: A Personalized Nutrition Approach to Understanding the Relationship of Red Meat to Health - #70348-I
- ( 10/01/2023 - 09/30/2025 ) Beef Checkoff
- Role: PI
- Subclinical Vascular Contributions to Alzheimer's Disease: The Multi Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD - #R01 AG058969
- ( 07/01/2024 - 06/30/2029 ) NIH-NIA
- Role: Site PI
- Longitudinal Omics-Based Trajectories of Type 2 Diabetes Subtypes: The T2D Heterogeneity Consortium - #U01 DK058969
- ( 07/01/2024 - 06/30/2029 ) NIH-NIDDK
- Role: MPI (Manning, Wood, Qi, Rotter). Our overarching goal is to integrate clinical and multi-omic data into prediabetes and type 2 diabetes classification and build prediction models of disease trajectories over the lifespan. Our central hypothesis is that multi-omic data can refine definitions of type 2 diabetes, identify those patients most like to develop complications, and better identify people at risk for future development of type 2 diabetes. Our approach is to apply sophisticated clustering in diverse, longitudinal cohorts over rich omics data to identify subgroups of individuals who develop type 2 diabetes.
- Multiethnic and multiomics analysis of longitudinal changes in DNA methylation and Cardiovascular health - #1R01HL176728-01A1
- ( 09/17/2025 - 09/16/2029 ) Grant funding from NIH-NHLBI
- Role: Site PI (PI: Ma) The proposed project will integrate longitudinal change in DNA methylation with behavioral and clinical cardiovascular health factors, genetic and multi-omics markers, and adjudicated cardiovascular disease and death events in ~13,500 participants with diverse backgrounds from four well-established population-based studies. Our analysis will establish temporal relationships to facilitate the identification of the causal DNA methylation loci for cardiovascular disease.
- Diet and Neurocognitive Development: A Metabolomic Enhanced Analysis - #3092-51000-063-000D
- ( 09/01/2024 - 08/31/2029 ) Grant funding from USDA/ARS
- Role: PI This project will (1) leverage existing observational data on over 8,000 US and European children, available from The Environmental Determinants of Diabetes in the Young (TEDDY) study, and examine associations between parent-reported dietary intake with metabolome-wide metabolites from ages 12-24m; and (2) establish a new longitudinal cohort of toddlers in Houston, TX and measure their metabolome and cognitive development. Together these data will be used to examine associations between dietary intake from 12-24m of age, and of diet-related metabolites, with cognitive functioning at 18-24m in order to inform the development and refinement of natinale-level dietary guidelines for this age group.
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