Researchers reported that profiling the bone marrow “metabolome" at the time of pediatric acute lymphoblastic leukemia diagnosis enabled them to identify patients who were most likely to respond poorly to treatment.
In a recent study, researchers combined clinical and laboratory studies to show the PPM1D gene can confer blood cells exposed to the chemotherapy agent cisplatin a survival advantage that might favor the development of leukemia years later.
To better understand a predisposition for acute lymphoblastic leukemia in children with Down syndrome, a team of researchers will sequence the genomes of more than 2,000 individuals with Down syndrome.
In a review published in New England Journal of Medicine, physician-scientists review the history of Langerhans-cell histiocytosis (LCH) and the recent developments that will help propel the treatment for patients into the realm of personalized medicine.
Baylor College of Medicine has received a Rally for Research Grant from the Rally Foundation for Childhood Cancer Research to support Dr. Tsz-Kwong (Chris) Man and his research in targeting methylome in chemo-resistant osteosarcoma.