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research › ... › research-projects
… Wang Lab first uses electron cryo-microscopy (Cryo-EM) to determine the structural architecture of DNA-bound ER-alpha, SRC-3, and a secondary coactivator (p300) complex. This work provides a structural basis for understanding the assembly of a … the most enduring project in my research, spanning the last decade. Expression of the efflux pump is one the major …
news › pkmyt1-a-potential-achilles-heel-of-treatment-resistant-er-breast-cancers-with-the-poorest-prognosis
… Up to 80% of breast cancer deaths occur in patients with tumors that express estrogen … cancers often initially respond to standard treatment that combines endocrine therapies with CDK4/6 inhibitors, drug resistance often develops leading to lethal metastatic disease that spreads …
research › ... › publications
… CA, Barnes S, Cristobal CDD, Kurtz K, Brunetti L, Goodell MA, Rau RE. Modeling IKZF1 lesions in B-ALL reveals distinct … K, Huang Y, Cheng X, Meissner A, Valk PJM, Van Maldergem L, Sanders MA, Blundell JR, Li W, Ebert BL, Goodell … A, Guarente V, Spinozzi G, Tini V, Martelli MP, Goodell MA, Falini B. Bcor deficiency perturbs …
research › ... › alumni
… Dobrawa (2001-2007) Current Position: Associate Professor (Dental Medicine) - University of Pittsburgh, Pittsburgh, PA … Assistant Professor (Center for Skeletal Diseases) – Van Andel Research Institute, Grand Rapids, MI Tao, Jianning … (Institute of Aquaculture) - University of Santiago de Compostela, Spain Suzuki, Masataka (2008-2010) Current …
research › ... › publications
… LC-MS/MS and the generation of a PRSS37 humanized mouse model. Sci Rep. 2023 Chen Y, Leng M, Gao Y, Zhan D, Choi JM, … Malovannaya A, Qin J, Jung SY, Wang Y. A Cross-Linking-Aided Immunoprecipitation/Mass Spectrometry Workflow Reveals … Intracellular Trafficking in Time-Resolved, Signal-Dependent Epidermal Growth Factor Receptor Proteome . J …
news › compassion-and-art-of-medicine-series-begins
… The annual Compassion and the Art of Medicine series hosted by Baylor … followed by a question-and-answer session at 1 p.m. BCM's department of family and community medicine presents the series with a grant from The … Fisher graduated from Tufts University with a bachelor's degree in political science and a certificate in community …
news › unanticipated-response-to-estrogen-at-the-single-cell-level
… the level of estrogen receptor nor its activation status determined asynchronous cellular responses. However, a … to hormone, establishing a previously unrecognized mode of regulation of estrogen-induced gene activation at the … before in estrogen receptor biology, they were not a complete surprise. Studies in genetically identical bacteria …
news › scientists-uncover-nuclear-droplets-that-link-multiple-leukemias-revealing-new-therapeutic-target
… A hidden structure inside the cell is rewriting how scientists … different genetic drivers of leukemia use the same secret compartments inside the cell nucleus to keep cancer growing. … proteins form droplets through a process known as phase separation, teamed with Dr. Margaret “Peggy” Goodell , …
news › alterations-in-human-gene-trpc5-cause-obesity-and-postpartum-depression
… in the human gene TRPC5 cause obesity and postpartum depression. Taken together, their studies in cells, animal … the role of TRPC5 in obesity and postpartum depression. By combining the individual expertise of each lab – basic and … high levels of Trpc5 expression in oxytocin neurons in the paraventricular nucleus of the hypothalamus (PVH) in mice. …
departments › ... › funded-projects
… with germline POT1 mutations have a higher risk of developing gliomas, which comprise the majority of malignant primary brain tumors. … glioma initiation, incorporating a multitude of important parameters such as cell cycle and telomere biology. … Neurosurgery Funded Projects …
