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research › ... › molecular-chaperones
… A majority of proteins must fold correctly in order to attain biological function. Although the protein … is essential for cell and organismal health. To accomplish this, cells have evolved a sophisticated network of protein quality control machines consisting of molecular chaperones and energy-dependent proteases, which monitor …
research › ... › transcription-regulation
… RNA Polymerase II (Pol II) transcription is a highly regulated process, which is responsible for the transcription of … machinery is the same for both basal (activator-independent) and activated transcription as observed in vitro … facilitating the assembly and function of the preinitiation complex (PIC). It is now widely accepted that binding of the …
research › ... › high-school-students
… We have hosted a few curious high school students over the years. These students usually spend part of a summer shadowing laboratory personnel. Sometimes they help with some aspects … Zechiedrich Lab High School Students …
research › ... › post-baccalaureate-students
… Zechiedrich Lab Post-Baccalaureate Students …
research › ... › postdoctoral-research-fellows
… Zechiedrich Lab Postdoctoral Research Fellows …
research › ... › research-background
… have many known functions in the biology of the genome; however, there is much yet to be understood. We are particularly interested in how chromatin appears to function in complex multivalent … similar biological scopes, top down proteomic fundamentally answers different questions than its more familiar cousin …
research › ... › research-projects
… Estrogen receptor-positive (ER+) breast cancer comprises 70% of human breast cancer cases. Although there exist many … on estrogen for continued growth. These new models now offer unparalleled tools to investigate multiple critical … (ER+) breast cancer predominantly recurs in bone, often years and occasionally decades after surgical …
research › ... › grants-and-funding
… We are generously funded through a variety of institutions and foundations: National Heart, Lung and Blood Institute (R01 HL130249) National Heart, Lung and Blood … (R21 OD025327) March of Dimes - Basil O’Connor Starter Scholar Research Award Parker B. Francis Fellowship Program …
research › ... › projects
… As an estrogen-dependent pro-inflammatory disease, endometriosis is defined as the colonization and growth of endometrial tissues at anatomic … level is significantly elevated in endometriotic tissues as compared with normal endometriosis. Now, we will investigate …
research › ... › publications
… apoptosis . The Journal of endocrinology. 2018;237(3):255-269. Cho YJ, Lee SH, Park JW, Han M, Park MJ, Han SJ. … 2016 Jan;89(1):14-26. … 17 Nov 2015:Vol. 8, Issue 403, pp. ec338 DOI: 10.1126/scisignal.aad8685. Highlighted in …