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… Genetic studies show that a high frequency of IDH (isocitrate … studies as well as clinical evidence suggest IDH mutation plays important roles in cancer initiation and/or progression. We are using a combination of chemical, biophysical and molecule & cell …
research › faculty-labs › bing-zhang-lab
… Complex diseases, such as cancer, heart disease, stroke, and diabetes, have been the leading causes of death in the United States for the last half century. The underlying molecular mechanisms of … Analyzing both the entire set of genes and all the proteins produced by colon …
research › faculty-labs › choel-kim-lab
… The Kim lab focuses on molecular targeting mechanisms of cGMP-dependent protein kinases. … tomography X-Ray Crystallography High Throughput Screening Spectroscopy and Biophysical Method … Choel Kim Lab …
research › faculty-labs › robert-waterland-lab
… In the Waterland lab we are passionate about understanding nutritional influences on mammalian developmental epigenetics, to gain a better picture of how nutrition … More than 15 years after scientists first mapped the human genome, researchers at the USDA/ARS Children’s Nutrition …
research › faculty-labs › roy-sillitoe-lab
… Brain circuits are highly complex and require carefully executed developmental programs for proper connectivity and function. Not surprisingly, genetic and … Roy Sillitoe Lab …
research › faculty-labs › schiff-osborne-lab
… The Schiff-Osborne laboratory is a team effort between Rachel Schiff, Ph.D., a molecular biologist and … and anti-HER2 therapy resistance and effective drug combinations to overcome it, several of which have been … functional validation studies, the Schiff-Osborne lab continues to discover novel mechanisms of resistance, …
research › faculty-labs › sundeep-keswani-lab
… The Laboratory for Regenerative Tissue Repair is focused on … molecular mechanisms that underlie the fetus’ ability to regeneratively heal cutaneous wounds and the development of … and mechanotransduction in tissue repair outcomes. See a listing of our lab members and publications. …
research › faculty-labs › suzanne-fuqua-lab
… The main goal of the Fuqua Lab's research is to determine the role of specific somatic mutations in estrogen receptor alpha, called K303R and Y537N ERa, in the … aromatase inhibitor anastrazole. The Y537N mutation is a constitutionally active receptor first discovered in …
research › faculty-labs › daoyun-ji-lab
… The Ji Lab investigates how the neural circuits in the brain encode, consolidate, and retrieve memories. … The brain is incredibly efficient at turning whatever happens to us into the so-called episodic memory. The life-long accumulation of episodic memories greatly defines who we are and …
research › faculty-labs › george-rodney-lab
… Real-time imaging of sub-cellular reactive oxygen species, Ca2+ signaling, and excitation-contraction coupling in skeletal muscle under physiological … Site-specific ROS inhibitors as potential therapeutic targets. The identification of redox signaling pathways that contribute to muscle contractile dysfunction may provide …