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Research

Genetically Engineered Rodent Models Core

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About the Core

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The Genetically Engineered Rodent Models (GERM) Core possesses specialized expertise and state-of-the-art equipment for providing essential mouse services to investigators at Baylor College of Medicine and collaborative investigators of other institutes. Our core assists investigators with projects involving the production of transgenic, targeted knockout, and targeted knock-in mouse lines.

Knockout and knock-in mouse lines can be generated using gene targeting in embryonic stem (ES) cells with chimera production or CRISPR genome editing in mouse zygotes. For projects involving CRISPR genome editing, the GERM Core offers a genome editing design service (guide selection, donor DNA design, and genotyping design) in addition to an on- and off-target mutagenesis genotyping service.

The GERM Core also performs cryopreservation of mouse embryos and sperm for long-term storage of mouse lines, mouse line rederivation, in vitro fertilization, and mouse colony expansion.

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