Retinogenesis requires a tightly controlled balance of retinal progenitor cell (RPC) proliferation and differentiation, and the deregulation of this mechanism often results in profound neuro-developmental disorders or cancer. Despite the clear biological and clinical importance, the full complement of molecular players involved is still unknown.
The lab's long term goals are to elucidate the transcriptional and epigenetic mechanisms regulating RPC proliferation and differentiation, leading to new therapeutic interventions to restore sight and treat cancers such as retinoblastoma. Toward that end, projects aimed at characterizing novel mouse mutants suffering from defects in retinogenesis are ongoing.
In the lab, we employ a multi-disciplinary approach utilizing genetic loss- and gain-of-function experiments, molecular biology and live retinal confocal microscopy.