Publications

Ebrahimpour A, Shrestha S, Bonnen MD, Eissa NT, Raghu G, Ghebre YT. Nicotine Modulates Growth Factors and MicroRNA to Promote Inflammatory and Fibrotic Processes. 2019; 368(2):169-178. PubMed [journal] PMID: 30446578

Ghebre YT, Raghu G. Response to Letter Regarding Article, “Proton Pump Inhibitors in IPF: Beyond mere suppression of gastric acidity.” QJM: An International Journal of Medicine. 2017; 110(4):263-264. PubMed [journal] PMID: 28158726

Li L, Mok H, Jhaveri P, Bonnen MD, Sikora AG, Eissa NT, Komaki RU, Ghebre YT. Anticancer therapy and lung injury: molecular mechanisms. Expert review of anticancer therapy. 2018; 18(10):1041-1057. PubMed [journal] PMID: 29996062

Pham N, Bonnen MD, Ghebre YT. Silent Neoplastic Cardiac Invasion in Small Cell Lung Cancer: A Case Report and Review of the Literature. The American journal of case reports. 2018; 19:619-622. PubMed [journal] PMID: 29844305

Ghebre YT. Proton Pump Inhibitors in IPF: A Call for Clinical Trials. Frontiers in pharmacology. 2018; 9:499. PubMed [journal] PMID: 29867501, PMCID: PMC5966555

Nelson C, Lee J, Ko K, Sikora AG, Bonnen MD, Enkhbaatar P, Ghebre YT. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Frontiers in pharmacology. 2017; 8:16. PubMed [journal] PMID: 28184197, PMCID: PMC5266706

Ghebre YT, Yakubov E, Wong WT, Krishnamurthy P, Sayed N, Sikora AG, Bonnen MD. Vascular Aging: Implications for Cardiovascular Disease and Therapy. Translational medicine (Sunnyvale, Calif.). 2016; 6(4). NIHMSID: NIHMS902443 PubMed [journal] PMID: 28932625, PMCID: PMC5602592

Ghebre Y, Raghu G. Proton pump inhibitors in IPF: beyond mere suppression of gastric acidity. QJM: monthly journal of the Association of Physicians. 2016; 109(9):577-579. PubMed [journal] PMID: 27647940, PMCID: PMC5943831

Ghebre YT. Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis: flip side of the story. Inflammation and cell signaling. 2016; 3(3). NIHMSID: NIHMS920317 PubMed [journal] PMID: 29302606, PMCID: PMC5749412

Ghebre YT, Raghu G. Idiopathic Pulmonary Fibrosis: Novel Concepts of Proton Pump Inhibitors as Antifibrotic Drugs. American journal of respiratory and critical care medicine. 2016; 193(12):1345-52. PubMed [journal] PMID: 27110898, PMCID: PMC4910893

Yepuri G, Sukhovershin R, Nazari-Shafti TZ, Petrascheck M, Ghebre YT, Cooke JP. Proton Pump Inhibitors Accelerate Endothelial Senescence. Circulation research. 2016; 118(12):e36-42. NIHMSID: NIHMS783595 PubMed [journal] PMID: 27166251, PMCID: PMC4902745

Zhou G, Meng S, Li Y, Ghebre YT, Cooke JP. Optimal ROS Signaling Is Critical for Nuclear Reprogramming. Cell reports. 2016; 15(5):919-925. NIHMSID: NIHMS774311 PubMed [journal] PMID: 27117405, PMCID: PMC4856580

Lai L, Ghebremariam YT. Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers. Journal of diabetes research. 2016; 2016:1982096. PubMed [journal] PMID: 26770984, PMCID: PMC4684877

Ghebremariam YT, Cooke JP, Gerhart W, Griego C, Brower JB, Doyle-Eisele M, Moeller BC, Zhou Q, Ho L, de Andrade J, Raghu G, Peterson L, Rivera A, Rosen GD. Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis. Journal of translational medicine. 2015; 13:249. PubMed [journal] PMID: 26231702, PMCID: PMC4522053

Ghebremariam YT, Cooke JP, Khan F, Thakker RN, Chang P, Shah NH, Nead KT, Leeper Proton pump inhibitors and vascular function: A prospective cross-over pilot study. Vascular medicine (London, England). 2015; 20(4):309-16. NIHMSID: NIHMS720238 PubMed [journal] PMID: 25835348, PMCID: PMC4572842

Sukhovershin RA, Ghebremariam YT, Cooke JP. Lansoprazole worsens asthma control in poor metabolizers: is nitric oxide involved? Annals of the American Thoracic Society. 2015; 12(7):1109-10. PubMed [journal] PMID: 26203616, PMCID: PMC4566405

Sukhovershin RA, Yepuri G, Ghebremariam YT. Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy. Methodist DeBakey cardiovascular journal. 2015; 11(3):166-71. PubMed [journal] PMID: 26634024, PMCID: PMC4666423

Shah NH, LePendu P, Bauer-Mehren A, Ghebremariam YT, Iyer SV, Marcus J, Nead KT, Cooke JP, Leeper NJ. Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. PloS one. 2015; 10(6):e0124653. PubMed [journal] PMID: 26061035, PMCID: PMC4462578

Ghebremariam YT, Lee JC, LePendu P, Erlanson DA, Slaviero A, Shah NH, Leiper JM, Cooke JP. Response to letters regarding article, "unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine". Circulation. 2014; 129(13):e428. NIHMSID: NIHMS612274 PubMed [journal] PMID: 24687654, PMCID: PMC4105215

Ghebremariam YT, Huang NF, Kambhampati S, Volz KS, Joshi GG, Anslyn EV, Cooke JP. Characterization of a fluorescent probe for imaging nitric oxide. Journal of vascular research. 2014; 51(1):68-79. NIHMSID: NIHMS534555 PubMed [journal] PMID: 24335468, PMCID: PMC3927988

Ghebremariam YT, Erlanson DA, Cooke JP. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. The Journal of pharmacology and experimental therapeutics. 2014; 348(1):69-76. PubMed [journal] PMID: 24135074, PMCID: PMC3868884

Ghebremariam YT, LePendu P, Lee JC, Erlanson DA, Slaviero A, Shah NH, Leiper J, Cooke JP. Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine. Circulation. 2013; 128(8):845-53. NIHMSID: NIHMS510441 PubMed [journal] PMID: 23825361, PMCID: PMC3838201

Ghebremariam YT, Yamada K, Lee JC, Johnson CL, Atzler D, Anderssohn M, Agrawal R, Higgins JP, Patterson AJ, Böger RH, Cooke JP. FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats. PloS one. 2013; 8(4):e60653. PubMed [journal] PMID: 23593273, PMCID: PMC3617194

Lependu P, Iyer SV, Bauer-Mehren A, Harpaz R, Ghebremariam YT, Cooke JP, Shah NH. Pharmacovigilance using Clinical Text. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science. 2013; 2013:109. PubMed [journal] PMID: 24303315, PMCID: PMC3814501

White MP, Rufaihah AJ, Liu L, Ghebremariam YT, Ivey KN, Cooke JP, Srivastava D. Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem cells (Dayton, Ohio). 2013; 31(1):92-103. NIHMSID: NIHMS415040 PubMed [journal] PMID: 23079999, PMCID: PMC3528812

Ghebremariam YT, Erlanson DA, Yamada K, Cooke JP. Development of a dimethylarginine dimethylaminohydrolase (DDAH) assay for high-throughput chemical screening. Journal of biomolecular screening. 2012; 17(5):651-61. NIHMSID: NIHMS447138 PubMed [journal] PMID: 22460174, PMCID: PMC3606823

Cooke JP, Ghebremariam YT. DDAH says NO to ADMA. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31(7):1462-4. NIHMSID: NIHMS303174 PubMed [journal] PMID: 21677286, PMCID: PMC3132190

Cooke JP, Ghebremariam YT. Dietary nitrate, nitric oxide, and restenosis. The Journal of clinical investigation. 2011; 121(4):1258-60. PubMed [journal] PMID: 21436578, PMCID: PMC3069795

Ghebremariam YT, Engelbrecht G, Tyler M, Lotz Z, Govender D, Kotwal GJ, Kahn D. Vaccinia virus complement control protein (VCP) improves kidney structure and function following ischemia/reperfusion injury in rats. The Journal of surgical research. 2010; 159(2):747-54. PubMed [journal] PMID: 19691975

Yang WC, Patel KG, Lee J, Ghebremariam YT, Wong HE, Cooke JP, Swartz JR. Cell-free production of transducible transcription factors for nuclear reprogramming. Biotechnology and bioengineering. 2009; 104(6):1047-58. NIHMSID: NIHMS308793 PubMed [journal] PMID: 19718703, PMCID: PMC3142170

Cooke JP, Ghebremariam YT. Endothelial nicotinic acetylcholine receptors and angiogenesis. Trends in cardiovascular medicine. 2008; 18(7):247-53. NIHMSID: NIHMS100739 PubMed [journal] PMID: 19232953, PMCID: PMC2673464

Thorgersen EB, Ghebremariam YT, Thurman JM, Fung M, Nielsen EW, Holers VM, Kotwal GJ, Mollnes TE. Candidate inhibitors of porcine complement. Molecular immunology. 2007; 44(8):1827-34. PubMed [journal] PMID: 17109963

Kotwal GJ, Kaczmarek JN, Leivers S, Ghebremariam YT, Kulkarni AP, Bauer G, De Beer C, Preiser W, Mohamed AR. Anti-HIV, anti-poxvirus, and anti-SARS activity of a nontoxic, acidic plant extract from the Trifollium species Secomet-V/anti-vac suggests that it contains a novel broad-spectrum antiviral. Annals of the New York Academy of Sciences. 2005; 1056:293-302. PubMed [journal] PMID: 16387696

Ghebremariam YT, Smith SA, Anderson JB, Kahn D, Kotwal GJ. Intervention strategies and agents mediating the prevention of xenorejection. Annals of the New York Academy of Sciences. 2005; 1056:123-43. PubMed [journal] PMID: 16387682

Ghebremariam YT, Odunuga OO, Janse K, Kotwal GJ. Humanized recombinant vaccinia virus complement control protein (hrVCP) with three amino acid changes, H98Y, E102K, and E120K creating an additional putative heparin binding site, is 100-fold more active than rVCP in blocking both classical and alternative complement pathways. Annals of the New York Academy of Sciences. 2005; 1056:113-22. PubMed [journal] PMID: 16387681

Kulkarni AP, Ghebremariam YT, Kotwal GJ. Curcumin inhibits the classical and the alternate pathways of complement activation. Annals of the New York Academy of Sciences. 2005; 1056:100-12. PubMed [journal] PMID: 1638768

Y.T. Ghebremariam et al. Human Xenotransplantation: An Immunological and Ethical Challenge. New Research on Immunology pp. 127-45. Nova science Publishers (2005), Inc. Editor: Veskler BA

Yohannes T. Ghebremariam et al. Intervention Strategies and Agents Mediating the Prevention of Xenorejection. Annals of the New York Academy of Science 1056(2005): 123-143.

Hanania AN, Mainwaring W, Ghebre YT, Hanania NA, Ludwig M. Radiation-induced Lung Injury: Assessment and Management. Chest 2019; pii:S0012-3692(19)30828-1. PMID: 30998908.

Li L, Mok H, Jhaveri P, Bonnen MD, Sikora AG, Eissa NT, Komaki RU, Ghebre YT*. Anticancer therapy and lung injury: molecular mechanisms. Expert Rev Anticancer Ther. 2018; 1-17. PMID: 29996062.

Ghebre Y. Proton Pump Inhibitors in IPF: A Call for Clinical Trials. Front Pharmacol 2018; 9:499. PMID: 29867501.

Ghebre Y and Raghu G.proton pump inhibitors in IPF: Beyond mere suppression of gastric acidity. QJM: An International Journal of Medicine. Oxford University 2016; 109(9):577-579. PMID: 27647940.

Ghebre YT. Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis: flip side of the story. Inflammation & Cell Signaling. 2016; 3:e1397. PMID: 29302606.

Ghebre YT and Raghu G.Idiopathic pulmonary fibrosis: Novel concepts of proton pump inhibitors as antifibrotic drug. Am J Respir Crit Care Med 2016; 193(12); 1345-52. PMID: 27110898.

Ghebre YT*, Yakubov E, Wong WT, Krishnamurthy P, Sayed N, Sikora A, and Bonnen M. Vascular aging: Implications for cardiovascular diseases and therapy. Translational Medicine 2016; 6:183. PMID: 28932625. PMCID: PMC5602592 (*corresponding author).

Li Lai and Yohannes T Ghebremariam*. DDAH as a novel target in insulin resistance. Journal of Diabetes Research 2016, 2016:1982096. PMID: 26770984 (*corresponding author).

Roman A Sukhovershin, Gautham Yepuri, and Yohannes T Ghebremariam*. Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy. Methodist DeBakey Cardiovascular J 2015, 11(3):166-71. PMID: 26634024 (*corresponding author).

Cooke JP and Yohannes T Ghebremariam. Endothelial Nicotinic Acetylcholine Receptors and Angiogenesis. Trends in Cardiovascular Medicine 2008 Oct; 18(7):247-53. PMID: 19232953.

Cooke JP, Ghebremariam YT. Dietary nitrate, nitric oxide, and restenosis. J Clin Invest. 2011 Apr 1;121(4):1258-60. PMID: 21436578PMCID: PMC3069795.

Cooke JP, Ghebremariam YT. DDAH says NO to ADMA. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1462-4. PMID: 21677286. PMCID: PMC3132190.

Ghebre YT, Raghu G. Response to letter regarding article, "proton pump inhibitors in IPF: beyond mere suppression of gastric acidity". QJM: An International Journal of Medicine. Oxford University 2017; 110(4):263-264. PMID: 28158726.

Sukhovershin RA, Ghebremariam YT and Cooke JP. Letter regarding the article “Lansoprazole is associated with worsening asthma control in children with the CYP2C19 poor metabolizer phenotype”. Annals of the American Thoracic Society 2015. PMID: 26203616.

Pham N, Bonnen MD and Ghebre YT*. Neoplastic cardiac invasion in small cell lung cancer. American Journal of Case Reports. Am J Case Rep. 2018; 19:619-622. PMID: 29844305