Modeling and targeting metastatic and high-risk sarcomas: Insights into molecular pathogenesis and pre-clinical testing of new therapeutic interventions
Specific projects include:
- Identification and targeting mechanisms of therapeutic resistance
- Characterization and targeting tumor metabolism in pediatric sarcomas
- Role of c-Myc and PVT-1 in the development and progression of osteosarcoma
- Characterization and targeting p21-activated kinases (PAKs) in pediatric sarcomas
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