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Jason Yustein Lab

Projects

Master
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Modeling and targeting metastatic and high-risk sarcomas: Insights into molecular pathogenesis and pre-clinical testing of new therapeutic interventions

Specific projects include:

  • Identification and targeting mechanisms of therapeutic resistance 
  • Characterization and targeting tumor metabolism in pediatric sarcomas
  • Role of c-Myc and PVT-1 in the development and progression of osteosarcoma
  • Characterization and targeting p21-activated kinases (PAKs) in pediatric sarcomas

Please contact us for additional details at yustein@bcm.edu.

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2)	Summary diagram of miR-130b /CDC42/PAK1/AP-1 oncogenic, positive feedback loop in Ewing sarcoma.
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Summary diagram of miR-130b /CDC42/PAK1/AP-1 oncogenic, positive feedback loop in Ewing sarcoma.

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Diagram of ex vivo pulmonary metastasis assay
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Diagram of ex vivo pulmonary metastasis assay demonstrating effect of Tegavivint on β-catenin-mediated transcriptional activity in PDX-derived lung cells. Representative images of lung slices treated with DMSO or Tegavivint. mCherry is constitutively expressed in all tumor cells, and β-catenin/TCF activity is represented with GFP. Fluorescent images of whole lung lobes in each group is shown.

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Design and characterization of a novel genetically engineered mouse model of metastatic osteosarcoma
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Design and characterization of a novel genetically engineered mouse model of metastatic osteosarcoma. Tumor histopathology demonstrating primary osteoblastic osteosarcoma (upper left panel) and distal lung metastatic lesions (upper right panel). Spectral karyotype of a primary osteosarcoma (bottom panel).