!

COVID-19 Response 

Access our COVID-19 Response homepage, with more information and resources during the COVID-19 pandemic, including what to do if you’re experiencing symptoms.

Daniel Lacorazza Lab

Publications

Master
Content

Park CS, Lacorazza HD. Retroviral Transduction of Quiescent Murine Hematopoietic Stem Cells. Methods Mol Biol. 2018;1686:173-182. doi: 10.1007/978-1-4939-7371-2_13.

Lacorazza H.D. KLF4 represses MAP2K7 signaling in T-ALL. Oncotarget. 2017 Sep 6;8(43):73366-73367. doi: 10.18632/oncotarget.20672

Shen Y, Chen TJ, Lacorazza HD. Novel tumor-suppressor function of KLF4 in pediatric T-cell acute lymphoblastic leukemia. (review) Experimental Hematology (2017). May 4 (Epub) doi: 10.1016/j.exphem.2017.04.009.

Shen Y, Park CS, Suppipat K, Mistretta TA, Puppi M, Horton TM, Rabin K, Gray NS, Meijerink JP, Lacorazza HD. Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway. Leukemia (2017). Jan 3. doi: 10.1038/leu.2016.339.

Aagaard KM, Lahon A, Suter MA, Arya RP, Seferovic MD, Vogt MB, Hu M, Stossi F, Mancini MA, Harris RA, Kahr M, Eppes C, Rac M, Belfort MA, Park CS, Lacorazza D, Rico-Hesse R. Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication. Sci. Rep. (2017). Jan 27;7:41389.

Kobayashi M, Nabinger SC, Bai Y, Yoshimoto M, Gao R, Chen S, Yao C, Dong Y, Zhang L, Rodriguez S, Yashiro-Ohtani Y, Pear WS, Carlesso N, Yoder MC, Kapur R, Kaplan MH, Daniel Lacorazza H, Zhang ZY, Liu Y. Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors. Stem Cells. 2016 Dec 23. doi: 10.1002/stem.2559.

Park CS, Shen Y, Lewis A, Lacorazza HD. Role of the reprogramming factor KLF4 in blood formation. J Leukoc Biol. 2016 May;99(5):673-85.

Lee, P-H., Yamada, T., Park, C.S., Shen, Y., Puppi, M., Lacorazza, H. D. G0S2 modulates homeostatic proliferation of naïve CD8+ T cells and inhibits oxidative phosphorylation in mitochondria. Immunology and Cell Biology [Nature] (2015) Feb 10. doi: 10.1038/icb.2015.9

Dorottya Nagy-Szakal, Sabina AV Mir, R. Alan Harris, Scot E. Dowd, Takeshi Yamada, H. Daniel Lacorazza, Nina Tatevian, C. Wayne Smith, Richard Kellermayer. Loss of omega-6 induced pediatric obesity protects against murine colitis. FASEB J (2015).

Suppipat, K. and Lacorazza, H.D. From the table to the bedside: Can the food-derived sulforaphane be a novel agent to treat leukemia? Current Cancer Drug Targets (2014). Epub May 21.

Lee, P-H., Puppi, M., Schluns, K.S., Yu-Lee, LY, Dong, C., and Lacorazza, H.D. Transcription factor ELF4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage. Journal of Immunology (2014), 192(1):177-188. View article.

Yamada, T., Park, C.S., and Lacorazza, H.D. Genetic control of quiescence in hematopoietic stem cells. Cell Cycle (2013); 12(15):2376-2383. View article.

Mamonkin, M.V., Shen, Y., Lee, P-H., Puppi, M., and Lacorazza, H.D. Differential roles of KLF4 in the development and differentiation of CD8+ T cells. Immunology Letters (2013); 156(1-2):94-101. View article.

Yamada, T., Park, C.S., Shen, Y., Rabin, K.R., and Lacorazza, H.D. G0S2 inhibits proliferation of K562 cells by interacting with nucleolin in the cytosol. Leukemia Research (2013). 10.1016/j.leukres.2013.10.006. View article.

Mamonkin, M.V., Puppi, M., and Lacorazza, H.D. Transcription factor ELF4 promotes development and function of memory CD8+ T cells in Listeria Monocytogenes infection. European Journal of Immunology (2013). DOI: 10.1002/eji.201343775 (In press)

Park, CS., Lee, PH., Yamada, T., Burns, A., Puppi, M., and Lacorazza, H.D. Krüppel-like Factor 4 (KLF4) Promotes the Survival of Natural Killer Cells and Maintains the Number of Conventional Dendritic Cells in the Spleen at Steady State. Journal of Leukocyte Biology (2012) 91(5): 739-750. [most viewed in 2012]

Yamada, T., Park, CS., Burns, A., Nakada, D., and Lacorazza, H.D. The Cytosolic Protein G0S2 Maintains Quiescence in Hematopoietic Stem Cells. PLoS One (2012) 7(5): e38280.

Suppipat K., Park, C.S., Shen, Y., Zhu, X., Lacorazza. H.D. Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells. PLoS One (2012) 7(12):e51251.

Sivina, M., Park, C.S., Yamada, T., Puppi, M., Coskun, S., Hirschi, K.K., and Lacorazza, H.D. Transcription factor ELF4 controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow. Arteriosclerosis, Thrombosis and Vascular Biology (2011), 31: 1185-1191.

Yamada, T., Gierach, K., Lee, P-H., Xiaohong Wang, and Lacorazza, H.D. Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells. Journal of Immunology (2010), 185:3824-3828.

Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2. Takeshi Yamada, Chun Shik Park, Maksim Mamonkin, and Daniel Lacorazza. Nature Immunology (2009), 16(6):618:26.

The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells. Lacorazza, H.D., Yamada, T., Liu, Y., Miyata, Y., Sivina, M., Nunes, J., Nimer, S.D. Cancer Cell (2006), 9:3.

Garcia-Barros, M., Lacorazza, H.D., Petrie, H., Haimovitz-Friedman, A., Cardon-Cardo, C., Nimer, S., Fuks, Z., Kolesnick, R. Host acid sphingomyelinase regulates microvascular function not tumor immunity. Cancer Res. (2004), 64(22): 8285-8291.

Lacorazza, H.D. and Nikolich-Zugich, J. Exclusion and Inclusion of TCR-alpha Proteins during T-cell Development in TCR-transgenic and normal mice. J. Immunol. (2004), 173(9): 5591-5600.

Lacorazza, H.D., and Nimer, S. The emerging role of the transcription factor MEF in hematopoiesis (review). Blood Cells, Molecules and Diseases. (2003), 31: 342-350.

Lacorazza, H.D., Miyazaki, Y., Di Cristofano, A., Deblasio, T., Hedvat, C., Cordon-Cardo, C., Mao, S., Zhang, J., Pandolfi, P.P., and Nimer, S.D. The ETS Protein MEF Plays a Critical Role in Perforin Gene Expression and the Development of Natural Killer Cells and NK-T Cells. Immunity. 2002, 17: 437-449.

Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nat Immunol. 2002, 3(5): 483-8.

Lacorazza, H.D., Porritt, H., and Nikolich-Zugich, J. Dysregulated expression of pre-Talpha reveals the opposite effects of pre-TCR at successive stages of T cell development. J. Immunol. 2001, 167:5689-5696.

Lacorazza, H.D., Tucek-Szavo, C., Vasovic, L., Remus, K., Nikolich-Zugich, J. Premature TCR alpha beta expression and signaling in early thymocytes impair thymocyte expansion and partially block their development. J. Immunol. 2001, 166:3184-3193.

Media Component
cover
Heading

HSC quiescence