Selected Publications
Lacorazza HD. The reprogramming factor KLF4 in normal and malignant blood cells.
Front Immunol. 2025 Jun 16;16:1584181. doi: 10.3389/fimmu.2025.1584181. eCollection 2025.PMID: 40589762
Park CS, Bridges CS, Lewis AH, Chen TJ, Shai S, Du W, Puppi M, Zorman B, Pavel S, Lacorazza HD. KLF4 enhances transplantation-induced hematopoiesis by inhibiting TLRs and noncanonical NFκB signaling at a steady state. Exp Hematol. 2025 Apr;144:104730. doi: 10.1016/j.exphem.2025.104730. Epub 2025 Feb 1.PMID: 39900173
Lacorazza HD. Pharmacological inhibition of the MAP2K7 kinase in human disease.
Front Oncol. 2024 Dec 9;14:1486756. doi: 10.3389/fonc.2024.1486756. eCollection 2024.PMID: 39717752
Kim DR, Orr MJ, Kwong AJ, Deibler KK, Munshi HH, Bridges CS, Chen TJ, Zhang X, Lacorazza HD, Scheidt KA. Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors. ACS Med Chem Lett. 2023 Apr 17;14(5):606-613. doi:10.1021/acsmedchemlett.3c00029. eCollection 2023 May 11.PMID: 37197477
Chambers C, Cermakova K, Chan YS, Kurtz K, Wohlan K, Lewis AH, Wang C, Pham A, Dejmek M, Sala M, Loeza Cabrera M, Aguilar R, Nencka R, Lacorazza HD, Rau RE, Hodges HC. SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia. Cancer Res. 2023 Apr 4;83(7):983-996. doi: 10.1158/0008-5472.CAN-22-2129.PMID: 36662812
Bridges CS, Chen TJ, Puppi M, Rabin KR, Lacorazza HD. Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia. Blood Adv. 2023 Feb 14;7(3):422-435. doi: 10.1182/bloodadvances.2022008548.PMID: 36399528
Salinas SA, Mace EM, Conte MI, Park CS, Li Y, Rosario-Sepulveda JI, Mahapatra S, Moore EK, Hernandez ER, Chinn IK, Reed AE, Lee BJ, Frumovitz A, Gibbs RA, Posey JE, Forbes Satter LR, Thatayatikom A, Allenspach EJ, Wensel TG, Lupski JR, Lacorazza HD, Orange JS. An ELF4 hypomorphic variant results in NK cell deficiency. JCI Insight. 2022 Dec 8;7(23):e155481. doi: 10.1172/jci.insight.155481.PMID: 36477361
Lewis AH, Bridges CS, Moorshead DN, Chen TJ, Du W, Zorman B, Sumazin P, Puppi M, Lacorazza HD. Krüppel-like Factor 4 Supports the Expansion of Leukemia Stem Cells in MLL-AF9-driven Acute Myeloid Leukemia. Stem Cells. 2022 Aug 25;40(8):736-750. doi: 10.1093/stmcls/sxac033.PMID: 35535819
Lewis AH, Bridges CS, Punia VS, Cooper AFJ, Puppi M, Lacorazza HD. Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells. Oncotarget. 2021 Feb 16;12(4):255-267. doi: 10.18632/oncotarget.27878. eCollection 2021 Feb 16. PubMed PMID: 33659038; PubMed Central PMCID: PMC7899553.
Chen TJ, Du W, Junco JJ, Bridges CS, Shen Y, Puppi M, Rabin KR, Lacorazza HD. Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia. Oncotarget. 2021 Aug 31;12(18):1787-1801. doi: 10.18632/oncotarget.28040. eCollection 2021 Aug 31.PMID: 34504651
Park CS, Lewis AH, Chen TJ, Bridges CS, Shen Y, Suppipat K, Puppi M, Tomolonis JA, Pang PD, Mistretta TA, Ma L, Green MR, Rau R, Lacorazza HD. A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells. Blood. 2019 Nov 28;134(22):1960-1972. doi: 10.1182/blood.2018875922. PubMed PMID: 31515251; PubMed Central PMCID: PMC6887114.
Park CS, Lewis A, Chen T, Lacorazza D. Concise Review: Regulation of Self-Renewal in Normal and Malignant Hematopoietic Stem Cells by Krüppel-Like Factor 4. Stem Cells Transl Med. 2019 Jun;8(6):568-574. doi: 10.1002/sctm.18-0249. Epub 2019 Feb 21. Review. PubMed PMID: 30790473; PubMed Central PMCID: PMC6525558.
Park CS, Lacorazza HD. Retroviral Transduction of Quiescent Murine Hematopoietic Stem Cells. Methods Mol Biol. 2018;1686:173-182. doi: 10.1007/978-1-4939-7371-2_13.
Shen Y, Park CS, Suppipat K, Mistretta TA, Puppi M, Horton TM, Rabin K, Gray NS, Meijerink JP, Lacorazza HD. Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway. Leukemia (2017). Jan 3. doi: 10.1038/leu.2016.339.
Yamada T, Park CS, Mamonkin M, Lacorazza HD. Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2.
Nat Immunol. 2009 Jun;10(6):618-26. doi: 10.1038/ni.1730. Epub 2009 May 3. PMID: 19412182
Lacorazza HD, Yamada T, Liu Y, Miyata Y, Sivina M, Nunes J, Nimer SD. The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells. Cancer Cell. 2006 Mar;9(3):175-87. doi: 10.1016/j.ccr.2006.02.017.PMID: 16530702