My career is focused on developing pragmatic and innovative psychotherapeutic interventions to improve the mental health and functioning of patients suffering from co-occurring psychiatric and chronic medical conditions. My training in clinical psychology underscored the value of psychotherapeutic interventions in medical settings, but also highlighted areas for growth. These include identifying novel treatment delivery methods that increase access and treatment adherence; developing new strategies to both identify and treat underreported and undertreated mental health difficulties in patients with chronic medical conditions; and elucidating the mechanisms by which effective treatments work. As a first step towards addressing these gaps, with an NIMH K23, I developed a one-day (five hour) behavioral intervention (based on Acceptance and Commitment Therapy- ACT), presented as a “workshop”, for patients with co-occurring migraine pain and depression. The results were striking – patients experienced significant drops in depression and disability. The promising findings motivated me to obtain NIH and VA funding to develop and test brief and accessible interventions in other medical populations including civilian and Veteran patients with chronic pain, cardiac disease, inflammatory bowel disease, and “at-risk” patients undergoing orthopedic surgery. Central to the success of these treatment trials has been my collaborations with medical specialists and members of the health care team. These partnerships allow for the tailoring and refinement of the therapeutic treatment and delivery strategy to meet the specific needs of the specific patient population.