Sudden Infant Death Syndrome claims the lives of as many as 14 infants each day in the United States alone. SIDS is typically defined as the death of an otherwise healthy infant, which leave few clues to understand how this devastating disease may occur. However, carefully controlled post-mortem studies have identified subtle brainstem abnormalities in areas critical to breathing. It remains unclear if these subtle abnormalities stem from genetic mutations, pre-natal exposures such as smoking and alcohol or both. To answer that question, we have developed a closed loop automated neonate respiratory measurement platform. View video. Using these robotic platforms, we are able to simultaneously test the breathing of large numbers of neonate mice under SIDS like conditions. We are currently leveraging these platforms to first screen a wide array mouse genetic mutants for SIDS like phenotypes and as well as to better understand how pre-natal exposures including alcohol, tobacco, stress, and diet and influence protective neonate respiratory reflexes.