Rachel Rau Lab

Rau Lab Publications

Master
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Tovy A, Rosas C, Gaikwad AS, Medrano G, Zhang L, Reyes JM, Huang YH, Arakawa T, Kurtz K, Conneely SE, Guzman AG, Aguilar R, Gao A, Chen CW, Kim JJ, Carter MT, Lasa-Aranzasti A, Valenzuela I, Van Maldergem L, Brunetti L, Hicks MJ, Marcogliese AN, Goodell MA, Rau RE. Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome. Haematologica. 2021 Jun 3;. doi: 10.3324/haematol.2021.278990. [Epub ahead of print] PubMed PMID: 34092059.

Junco JJ, Chen T, Rashid R, Terrell M, Gant VU, Miller M, Rau RE, Lacorazza HD, Rabin KR. An Mb1-Cre-driven oncogenic Kras mutation results in a mouse odel of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance. Leukemia. 2020 Sep 11. doi: 10.1038/s41375-020-01036-w. Online ahead of print. PMID: 32918044.

Park CS, Shen Y, Lewis AH, Suppipat K, Puppi M, Tomolonis J, Chen TJ, Pang P, Mistretta T-A, Ma L, Rau RE, Lacorazza HD. KLF4 represses DYRK2 inhibition of self-renewal and survival through c-Myc and p53 in leukemia stem cellsBlood. 2019 Nov 28;134(22):1960-1972. doi: 10.1182/blood.2018875922. PubMed PMID: 31515251; PubMed Central PMCID: PMC6887114.

Rau RESIRPAssing other xenograft murine models? Blood 2020 May 7;135(19):1612-1614. PMID: 32379878.

Rau RE, Rodriguez BA, Luo M, Jeong M, Rosen A, Rogers JH, Campbell CT, Daigle SR, Deng L, Song Y, Sweet S, Chevassut T, Andreeff M, Kornblau SM, Li W, Goodell MA. DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016 Aug 18;128(7):971-81. doi: 10.1182/blood-2015-11-684225. Epub 2016 Jun 22. PubMed PMID: 27335278; PubMed Central PMCID: PMC4990856.

Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee JS, Rau R, Li W, Goodell MA. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell. 2016 Jun 13;29(6):922-934. doi: 10.1016/j.ccell.2016.05.003. PubMed PMID: 27300438; PubMed Central PMCID: PMC4908977.

Eckstein OS, Wang L, Punia JN, Kornblau SM, Andreeff M, Wheeler DA, Goodell MA, Rau RE. Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes. Exp Hematol. 2016 Aug;44(8):740-4. doi: 10.1016/j.exphem.2016.05.003. Epub 2016 May 18. PubMed PMID: 27208809; PubMed Central PMCID: PMC4956537.

Rau R, Magoon D, Greenblatt S, Li L, Annesley C, Duffield AS, Huso D, McIntyre E, Clohessy JG, Reschke M, Pandolfi PP, Small D, Brown P. NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease. Exp Hematol. 2014 Feb;42(2):101-13.e5. doi: 10.1016/j.exphem.2013.10.005. Epub 2013 Oct 29. PubMed PMID: 24184354; PubMed Central PMCID: PMC3932758.

Yang L, Rau R, Goodell MA. DNMT3A in haematological malignancies. Nat Rev Cancer. 2015 Mar;15(3):152-65. doi: 10.1038/nrc3895. Epub 2015 Feb 19. Review. PubMed PMID: 25693834; PubMed Central PMCID: PMC5814392.

Conneely SE, Rau REThe genomics of acute myeloid leukemia in children. Cancer Metastasis Rev. 2020 Mar;39(1):189-209. doi: 10.1007/s10555-020-09846-1. Review. PubMed PMID: 31925603; PubMed Central PMCID: PMC7324027.

Rau RE, Goodell MA. Measure Twice, Cut Once: Therapeutic Editing of HSPCs Requires Precise Planning. Cell Stem Cell. 2019 Apr 4;24(4):511-512. doi: 10.1016/j.stem.2019.03.001. PubMed PMID: 30951659.

Annesley CE, Rabik C, Duffield AS, Rau RE, Magoon D, Li L, Huff V, Small D, Loeb DM, Brown P. Knock-in of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice. Oncotarget. 2018 Oct 19;9(82):35313-35326. doi: 10.18632/oncotarget.26238. eCollection 2018 Oct 19. PubMed PMID: 30450160; PubMed Central PMCID: PMC6219680. 

Rau RE, Loh ML. Using genomics to define pediatric blood cancers and inform practice. Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):286-300. doi: 10.1182/asheducation-2018.1.286. Review. PubMed PMID: 30504323; PubMed Central PMCID: PMC6245969.