Selected Publications (Present - 2014)
Corriveau ML, Amaya SI, Koebel MC, Lerma VC, Michener SL, Turner A, Schultz RJ, Seto ES, Diaz-Medina GE, Craigen WJ, Swann JW, Xue M, Chao HT (2023) PAK1 c.1409 T > a (p. Leu470Gln) de novo variant affects the protein kinase domain, leading to epilepsy, macrocephaly, spastic quadriplegia, and hydrocephalus: Case report and review of the literature. Am J Med Genet A. 191(6):1619-1625.
Lee D, Chen W, Kaku HN, Zhuo X, Chao ES, Soriano A, Kuncheria A, Flores S, Kim JH, Rivera A, Rigo F, Jafar-nejad P, Beaudet AL, Caudill MS, Xue M (2023) Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome. eLife 12:e81892.
Govorunova EG, Gou Y, Sineshchekov OA, Li H, Lu X, Wang Y, Brown LS, St-Pierre F, Xue M, Spudich JL (2022) Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition. Nat Neurosci. 25:967-974.
Stevens SR, Longley CM, Ogawa Y, Teliska LH, Arumanayagam AS, Nair S, Oses-Prieto JA, Burlingame AL, Cykowski MD, Xue M, and Rasband MN (2021) Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels. eLife 10:e66491. PMCID: PMC8257253
Fan S, Xu Y, Lu Y, Jiang Z, Li H, Morrill JC, Cai J, Wu Q, Xu Y, Xue M, Arenkiel BR, Huang C, Tong Q (2021) A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia. Nat Commun. 12:2662. PMCID: PMC8113586
Kim ER, Xu Y, Cassidy RM, Lu Y, Yang Y, Tian J, Li DP, Van Drunen R, Ribas-Latre A, Cai ZL, Xue M, Arenkiel BR, Eckel-Mahan K, Xu Y, Tong Q (2020) Paraventricular hypothalamus mediates diurnal rhythm of metabolism. Nat Commun. 11:3794. PMCID: PMC7393104
Zhu C, Jiang Z, Xu Y, Cai ZL, Jiang Q, Xu Y, Xue M, Arenkiel BR, Wu Q, Shu G, Tong Q (2020) Profound and redundant functions of arcuate neurons in obesity development. Nat Metab. 2:763-774. PMCID: PMC7687864
Zhu C, Xu Y, Jiang Z, Tian JB, Cassidy RM, Cai ZL, Shu G, Xu Y, Xue M, Arenkiel BR, Jiang Q, Tong Q (2020) Disrupted hypothalamic CRH neuron responsiveness contributes to diet-induced obesity. EMBO Rep 21:e49210. PMCID: PMC7332802.
Pignatelli M, Tejeda HA, Barker DJ, Bontempi L, Wu J, Lopez A, Palma Ribeiro S, Lucantonio F, Parise EM, Torres-Berrio A, Alvarez-Bagnarol Y, Marino RAM, Cai ZL, Xue M, Morales M, Tamminga CA, Nestler EJ, Bonci A (2020) Cooperative synaptic and intrinsic plasticity in a disynaptic limbic circuit drive stress-induced anhedonia and passive coping in mice. Mol Psychiatry doi: 10.1038/s41380-020-0686-8.
Chen W, Cai ZL, Chao ES, Chen H, Longley CM, Hao S, Chao HT, Kim JH, Messier JE, Zoghbi HY, Tang J, Swann JW, Xue M (2020) Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy. eLife 9:e48705. PMCID: PMC7056272.
Ren K, Yang H, Zhao Y, Chen W, Xue M, Miao H, Huang S, Liu J (2018) A robust AUC maximization framework with simultaneous outlier detection and feature selection for positive-unlabeled classification. IEEE Trans Neural Netw Learn Syst. doi: 10.1109/TNNLS.2018.2870666. PMCID: PMC7416499
Messier J, Chen H, Cai ZL, Xue M (2018) Targeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon. eLife 2018;7:e38506. PMCID: PMC6130974
Yin J, Chen W, Chao ES, Soriano S, Wang L, Wang W, Cummock SE, Tao H, Pang K, Pereira FA, Samaco RC, Zoghbi HY, Xue M, Schaaf CP (2018) Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome. Am J Hum Genet 102:296-308. PMCID: PMC5985472
Jiang X, Chen J, Bajić A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletić-Savatić M, Wang J (2017) Quantitative real-time imaging of glutathione. Nat Commun 8:16087. PMCID: PMC5511354
Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, van der Heijden ME, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HY (2017) Respiratory network stability and modulatory response to substance P require Nalcn. Neuron 94:294-303. PMCID: PMC5702257
Messier J (2017) The role of neuroligins in the cerebellum highlights the diversity of synapse-specifying molecules. J Neurosci. 2017;37
Yin J, Chen W, Yang H, Xue M, Schaaf CP (2017) Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes. Sci Rep 7:39941. PMCID: PMC5206704
Ure K, Lu H, Wang W, Ito-Ishida A, Wu Z, He L, Sztainberg Y, Chen W, Tang J, Zoghbi H (2016) Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome. eLife 2016;5:e14198
Meng X, Wang W, Lu H, He L, Chen W, Chao E, Fiorotto M, Tang B, Herrera J, Seymour M, Neul J, Pereira F, Tang J, Xue M, Zoghbi H (2016) Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders. eLife 2016;5:e14199
Selected Publications (Before 2014)
Xue M, Atallah BV, Scanziani M (2014) Equalizing excitation-inhibition ratios across visual cortical neurons. Nature 511:596-600.
Pfeffer CK, Xue M, He M, Huang ZJ, Scanziani M (2013) Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Nat Neurosci 16:1068-1076.
Xue M, Craig TK, Xu J, Chao HT, Rizo J, Rosenmund C (2010) Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Nat Struct Mol Biol 17:568-575.
Xue M, Lin YQ, Pan H, Reim K, Deng H, Bellen HJ, Rosenmund C (2009) Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron 64:367-380.
Xue M, Ma C, Craig TK, Rosenmund C, Rizo J (2008) The Janus-faced nature of the C2B domain is fundamental for Synaptotagmin-1 function. Nat Struct Mol Biol 15:1160-1168.
Xue M, Stradomska A, Chen H, Brose N, Zhang W, Rosenmund C, Reim K (2008) Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system. Proc Natl Acad Sci USA 105:7875-7880.
Xue M, Reim K, Chen X, Chao HT, Deng H, Rizo J, Brose N, Rosenmund C (2007) Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol 14:949-958.