James Versalovic Lab

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  6. Immunomodulins Identified in Lactobacillus reuteri

Immunomodulins Identified in Lactobacillus reuteri

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Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling.
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Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling.

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Histamine produced by L. reuteri is not modified
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Histamine produced by L. reuteri is not modified

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Histamine Concentration Correlates with TNF Inhibitory Activity. Histamine quantified using Triple Quadrupole MS
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Histamine Concentration Correlates with TNF Inhibitory Activity. Histamine quantified using Triple Quadrupole MS

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Histamine Produced by L. reuteri Inhibits the ERK Signaling Pathway
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Histamine Produced by L. reuteri Inhibits the ERK Signaling Pathway

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Histamine Produced by L. reuteri Inhibits TNF via the H2 Receptor
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Histamine Produced by L. reuteri Inhibits TNF via the H2 Receptor

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Histamine Produced by L. reuteri Inhibits TNF by Interacting with the H2 Receptor and inhibiting ERK Signaling
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Histamine Produced by L. reuteri Inhibits TNF by Interacting with the H2 Receptor and inhibiting ERK Signaling

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Publication:

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Thomas CM, Hong T, van Pijkeren JP, Hemarajata P, Trinh DV, Hu W, Britton RA, Kalkum M, Versalovic J. Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling. PLoS One. 2012;7(2):e31951. Epub 2012 Feb 22. PubMed PMID: 22384111; PubMed Central PMCID: PMC3285189. Article