Recent Publications
Skinnider MA, Johnston CW, Gunabalasingam M, Merwin NJ, Kieliszek AM, MacLellan RJ, Li H, Ranieri MRM, Webster ALH, Cao MPT, Pfeifle A, Spencer N, To QH, Wallace DP, Dejong CA, Magarvey NA. Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences. Nat Commun. 2020 Nov 27;11(1):6058. doi: 10.1038/s41467-020-19986-1. PMID: 33247171; PMCID: PMC7699628.
Johnston CW, Badran AH, Collins JJ. Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway. Nat Commun. 2020 Aug 21;11(1):4202. doi: 10.1038/s41467-020-18018-2. PMID: 32826900; PMCID: PMC7443133.
Merwin NJ, Mousa WK, Dejong CA, Skinnider MA, Cannon MJ, Li H, Dial K, Gunabalasingam M, Johnston C, Magarvey NA. DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):371-380. doi: 10.1073/pnas.1901493116. Epub 2019 Dec 23. PMID: 31871149; PMCID: PMC6955231.
Johnston CW, Collins JJ. Engineering microbial peer pressure. Science. 2019 Sep 6;365(6457):986-987. doi: 10.1126/science.aay3157. PMID: 31488676.
Johnston CW, Skinnider MA, Wyatt MA, Li X, Ranieri MR, Yang L, Zechel DL, Ma B, Magarvey NA. An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products. Nat Commun. 2015 Sep 28;6:8421. doi: 10.1038/ncomms9421. PMID: 26412281; PMCID: PMC4598715.
Skinnider MA, Johnston CW, Merwin NJ, Dejong CA, Magarvey NA. Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis. BMC Genomics. 2018 Jan 15;19(1):45. doi: 10.1186/s12864-018-4435-1. PMID: 29334896; PMCID: PMC5767969.
Skinnider MA, Merwin NJ, Johnston CW, Magarvey NA. PRISM 3: expanded prediction of natural product chemical structures from microbial genomes. Nucleic Acids Res. 2017 Jul 3;45(W1):W49-W54. doi: 10.1093/nar/gkx320. PMID: 28460067; PMCID: PMC5570231.