Email

xiangz@bcm.edu

Positions

Director

Lester and Sue Smith Breast Center

William T. Butler, M.D., Endowed Chair for Distinguished Faculty

Baylor College of Medicine

Professor

Molecular and Cellular Biology
Baylor College of Medicine
Houston, TX, US

Member

Dan L. Duncan Comprehensive Cancer Center

Education

Post-Doctoral Fellowship at Memorial Sloan Kettering Cancer Center

06/2011 - New York, New York, United States

PhD from Columbia University

05/2006 - New York, New York, United States

BS from Fudan University

01/2000 - Shanghai, China, People's Rep

Honors & Awards

Era of Hope Scholar

Department of Defense Congressionally Directed Medical Research Programs, Breast Cancer Research Program (03/2016 - 03/2021)

NIH Pathway to Independence Award (K99/R00)

National Cancer Institute (09/2010 - 09/2014)

Career Catalyst Research Award

Susan G. Komen Foundation (09/2014 - 08/2017)

Excellence in Research

Department of Molecular and Cellular Biology, BCM (08/2016)

Michael E. DeBakey Award for Excellence in Research

Baylor College of Medicine (05/2018)

Sue Eccles Young Investigator Award

Metastasis Research Society (08/2018)

Laura Zisken Prize

Stand Up To Cancer (01/2020 - 01/2021)

Leadership Award

Theresa's Research Foundation (10/2016)

Websites

Selected Publications

• Xiang H.-F. Zhang*, X Jin*, S Malladi, YH Wen, E Brogi, M Smid, JA Foekens, and J Massagué.. " Bone Metastasis seed pre-selection by the primary tumour stroma " Cell. 2013 ; 154 (5) : 1060-73.
  Pubmed PMID: 3974915.
• H Wang; C Yu; X Gao; T Welte; A Muscarella; L Tian; J Liu; H Zhao; Z Zhao; J Tao; B Lee; TF Westbrook; STC Wong; JM. Rosen; CK Osborne; Xiang H.-F. Zhang. " The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells " Cancer Cell. 2015 Feb 9; 27 (2) : 193-210.
• T Welte, IS Kim, L Tian, X Gao, H Wang, J Li, XB Holdman, JI Herschkowitz, A Pond, G Xia, S Kurley, T Nguyen, L Liao, LE Dobrolecki, Q Mo, DP Edwards, S Huang, L Xin, J Xu, Y Li, MT Lewis, T Wang, TF Westbrook, JM Rosen*, and Xiang H.-F. Zhang*. " Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation. " Nature Cell Biology. 2016 Jun ; 18 : 632-644.
• L Tian, A Goldstein, H Wang, IS Kim, HC Lo, T Welte, K Sheng, L Dobrolecki, X Zhang, N Putluri, T Phung, SA Mani, F Stossi, A Sreekumar, MA Mancini, C Zong, WK Decker, MT Lewis, and Xiang H.-F. Zhang. " Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming " Nature. 2017 Apr 3; 544 (7649) : 250-254.
• H Wang, L Tian, A Goldstein, HC Lo, J Liu, K Sheng, G Zbigniew, F Stossi, C Zong, Z Li, MA Mancini and Xiang H.-F. Zhang. " Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies " Nature Communications. 2017 ; 8 (15045) : DOI: 10.1038/ncomms15045.
• H Wang, L Tian, J Liu, A Goldstein, I Bado, W Zhang, BR Arenkiel, Z Li, M Yang, S Du, H Zhao, DR Rowley, STC Wong, Z Gugala, and Xiang H.-F. Zhang. " The osteogenic niche is a calcium reservoir of bone micrometastases and confers unexpected therapeutic vulnerability " Cancer Cell. ; 34 (5) : 823-839.
• Kim IS, Gao Y, Welte T, Wang H, Liu J, Janghorban M, Sheng K, Niu Y, Goldstein A, Zhao N, Bado I, Lo H-C, ..., Li Y, Mo Q, Westbrook TF, Zong C, Rao A, Sreekumar A, Rosen JM, Zhang XHF. " Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms " Nature Cell Biology. 2019 Sep ; 21 (9) : 1113-1126.
• Lo HC, Xu Z, Kim IS, Pingel B, Aguirre S, Kodali S, Liu J, Zhang W, Muscarella AM, Hein SM, Krupnick AS, Neilsen JR, Paust S, Rosen JM, Wang H, and Xiang H.-F. Zhang. " Resistance to Natural Killer cell immunosurveillance confers a selective advantage to polyclonal metastasis " Nature Cancer. 2020 ; 1 : 709–722.
• Muscarella MM, Dai W, Mitchell PG, Zhang W, Wang H, Jia L, Stossi F, Mancini MA, Chiu W, and Xiang H.-F. Zhang. " Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells " NPG Breast Cancer. 2020 Sep 7;
• Zhang W*, Bado IL*, Hu J, Wan YW, Wu L, Wang H, Gao Y, Jeong HH, Xu Z, Hao X, Lege BM, AI-Ouran R, Li L, Li J, Yu L, Singh S, Lo H-C, Niu M, Liu J, Jiang W, Li Y, Wong STC, Cheng C, Liu Z, Xiang H.-F. Zhang. " The bone microenvironment invigorates metastatic seeds for further dissemination " Cell. 2021 Apr 19; Online ahead of print (*: Equal contribution)
• Bado IL*, Zhang W*, Wang H, Hu J, Sarkar P, Liu J, Zbigniew G, Xu Z, Zhang W, Li L, Wan YW, Wu W, Lo H-C, Kim IS, Singh S, Janghorban M, Muscarella A, Goldstein A, Singh P, Jeong HH, Liu C, Huang S, Schiff R, Gaber MW, Liu Z, Ellis MJ, Xiang H.-F. Zhang. " The bone microenvironment increases phenotypic plasticity of ER+ breast cancer " Dev. Cell. 2021 Apr 19; 56 (8) : 1100-1117 *: equal contribution.
• Zeru Tian, Ling Wu, Chenfei Yu, Yuda Chen, Zhan Xu , Igor Bado , Axel Loredo , Lushun Wang , Hai Wang , Kuan-Lin Wu , Weijie Zhang , Xiang H.-F. Zhang*, Han Xiao*. " Harnessing the power of antibodies to fight bone metastasis " Sci. Adv.. 2021 Jun 23; 7 (eabf2051) : * Co-senior authors.
• Zhang W, Zhan X, Hao X, He T, Li J, Shen Y, Liu K, Gao Y, Liu J, Edwards DG, Muscarella AM, Wu L, Yu L, Xu L, Chen X, Wu YH, Bado IL, Ding Y, Aguirre S, Wang H, Gugala Z, Satcher RL, Wong STC, Xiang H.-F. Zhang. " Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells " Cancer Discovery. 2023 ; 13 (2) : 474-495.
• Hao X, Shen Y, Chen N, Zhang W, Valverde E, Wu L, Chan HL, Xu Z, Yu L, Gao Y, Bado I, Michie LN, Rivas CH, Becerra-Dominguez L, Aguirre S, Pingel BC, Wu Y-H, Liu F, Ding Y, Edwards DG, Liu J, ..., Shu-Hsia Chen, Mien-Chie Hung, Bora Lim, Xiang H.-F. Zhang. " Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal " Cell Stem Cell. 2023 ; 30 (5) : 648-664.
• X Hao, Y Shen, J Liu, ..., Ueno NT, Lim B, Xiang H.-F. Zhang. " The solid tumor-induced systemic immunosuppression involves dichotomous myeloid-B cell interactions " Nature Cell Biology. 2024 Nov ; 26 (11) : 1971-83.
• Yu L, Liebenberg K, Shen Y, Liu F, Xu Z, Wu L, Hao X, Zhang W, Chan HL, Wei B, Lorenzi P, Gao Y, Bado I, Dominguez LB, Rivas CH, Aguirre S, Pingel B, Wu, Y-H, Ding Y, Liu J, Edwards DG, Eberlin LS, and Xiang H.-F. Zhang. " Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer " Immunity. 2025 Apr 8; 58 (4) : 909-925.
• Liu F, Ding Y, Xu Z, Hao X, Pan T, Miles G, Wu Y-H, Liu J, Bado IL, Zhang W, Wu L, Gao Y, Yu L, Edwards DG, Chan HL, Aguirre S, Dieffenbach MW, Chen E, Shen Y, Hoffman D, Dominguez LB, Rivas CH, Chen X, Wang H, Gugala Z, Satcher RL, Xiang H.-F. Zhang. " Single-cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization. " Cell Genomics. 2025 Jul 9; (7) : 100888.
• Yu L, Liu F, Shen Y, Xu Z, Wu L, Ding Y, Hao X, Zhang W, Chan HL, Liu J, Wei B, Lorenzi PL, Gao Y, Becerra-Dominguez L, Rivas CH, Wu, YH, Wang S, Lee T, Li X, Edwards EG, Xiang H.-F. Zhang. " Inflammation- and resolution-programmed myeloid circuits drive dichotomous therapeutic resistance in epithelial and mesenchymal TNBC. " Journal of Clinical Investigation. 2026 ; Accepted
• Xu Z, Liu F, Ding Y, Pan T, Wu Y-H, Han Y, Liu J, Bado IL, Wu L, Gao Y, Hao X, Yu L, Li X, Edwards DG, Chan HL, Aguirre S, Dieffenbach MW, Chen E, Wang S, Shen Y, Hoffman D, ..., Kang Y, Gugala Z, Satcher RL, Xiang H.-F. Zhang. " Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization.. " Cell. 2026 ; Accepted

Show 15 more publications

Memberships

American Association of Cancer Research

Member (01/2012)

Metastasis Research Society

Member (03/2016)

American Association of Immunology

Member (12/2016)