Positions

Associate Professor
Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States
Acadamic Director, Metabolomics Core
Advanced Technology Core
Baylor College of Medicine
TX, Texas, United States
Director, Metabolomics Shared Resource
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

PhD from Indian Institute Of Chemical Technology-IICT
Analytical Chemistry-Mass Spectrometry, Metabolomics, Proteomics
MS from Osmania University
ORGANIC CHEMISTRY
BS from Osmania University
Post-Doctoral Fellowship at Pennington Biomedical Research Center, LSU
Proteomics
Post-Doctoral Fellowship at Medical College of Georgia
Metabolomics

Professional Statement

We are applying mass spectrometry technology to study metabolic profiling studies in cancer development and progression . I have established a robust research program in bladder cancer research. Particularly, we have characterized metabolic alterations associated with smoking in bladder cancer, health disparity and more recently defined a role xenobiotic metabolism in bladder cancer progression. Importantly, these studies have resulted in multiple publications (European Urology Focus 2017, Cancer Prevention Research, 2017, Oncotarget 2017, Journal of Urology 2016). I have been collaborating extensively with clinicians to translate some of his findings to the area of biomarker development.

Since joining Baylor College of Medicine as a core director, I have been instrumental in developing and establishing a state-of-the-art metabolomics core facility that has from an institutional wide entity to a Texas Medical Center wide service unit. Here I developed a unique unbiased mass spectrometry-based metabolic profiling platform in the area of cancer. I have also developed the methods for targeted profile, global metabolome and lipidome and most recently established the in vitro flux analysis platform, all of which are being heavily used to address key metabolic questions in area of cancer and metabolic diseases. These results on metabolomics flux are published in high impact papers like Cell (2014), Science (2018), Nature (2017, 2018) Journal of Clinical investigations (2014, 2015, 2017), Cell metabolism (2017) and Cancer Research (2011, 2016).

Selected Publications

Memberships

Sigma Xi
American Association for Cancer Research (AACR)
American Society of Mass Spectrometry
American Urological Association - AUA

Funding

Elucidating the Role of Xenobiotic Metabolism in Bladder Cancer Progression
Grant funding from American Cancer Society
RACIAL DISPARITY IN BLADDER CANCER AND IDENTIFICATION OF ALTERED METABOLISM IN AFRICAN AMERICAN COMPARE TO EUROPEAN BLADDER CANCER
- #R01CA220297
Grant funding from National Cancer Institute/NIH
IDENTIFY THE DNA ADDUCT AND ASSOCIATED METABOLIC ALTERATIONS IN BLADDER CANCER OF SMOKERS
- #RO1CA216426
Grant funding from National Cancer Institute/NIH