Email

miguelc@bcm.edu

Positions

Professor and Division Chief

Medicine
Thrombosis Research
Baylor College of Medicine
Houston, Texas, US

Co-Director

Center for Translational Research on Inflammatory Diseases (CTRID)
Michael E. DeBakey VA Medical Center
Baylor College of Medicine
Houston, Texas, United States

Research Health Scientist

Research Service Line
Michael E. DeBakey VA Medical Center
Houston, Texas, United States

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

Center for Translational Research on Inflammatory Diseases (CTRID) (Lab)

Michael E. DeBakey VA Medical Center
2002 Holcombe Blvd.
Houston, TX, 77030
United States
Phone: (713) 794-7775
miguelc@bcm.edu

Center for Translational Research on Inflammatory Diseases (CTRID) (Office)

Michael E. DeBakey VA Medical Center
2002 Holcombe Blvd.
Houston, TX, 77030
United States
Phone: (713) 794-7775
miguelc@bcm.edu

Education

PhD from University Of Puerto Rico School Of Medicine, Rio Piedras, Pr

01/1989 - Rio Piedras, PR

Biochemistry

Postdoctoral Fellowship at Harvard Medical School

01/1994 - Boston, Massachusetts, United States

Protein Biochemistry - Hematology

BS from University Of Puerto Rico, Rio Piedras, Puerto Rico

Rio Piedras, PR

Chemistry

Advanced Training from Brigham And Women's Hospital

01/1994 - Boston, MA, United States

Professional Interests

• Thrombosis, von Willebrand factor, platelet adhesion, DIC, extracellular hemoglobin, inflammation, vimentin, translational medicine

Websites

Selected Publications

• Da Q, Teruya M, Guchhait P, Teruya J, Olson JS, Cruz MA.. " Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications on circulatory devices. " Blood. 2015 ;
  Pubmed PMID: 26307534.
• Nguyen, TC, Gushiken, F, Correa, JI, Dong, J-F, Dasgupta, SK, Thiagarajan, P, Cruz, M.A.. " A recombinant fragment of von Willebrand factor reduces fibrin-rich microthrombi formation in mice with endotoxemia. " Thromb Res.. 2015 May ; 135
  Pubmed PMID: 25769494.
• Qi Da, Molly Behymer, Juliana I. Correa, K. Vinod Vijayan, and Miguel A. Cruz.. " Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress. " Blood. 2014 ; 123
  Pubmed PMID: 24642750.
• Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation " ;
  Pubmed PMID: 32259201.
• The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium " ;
  Pubmed PMID: 33048962.
• Links between thrombosis and inflammation in traumatic brain injury " ;
  Pubmed PMID: 33290884.
• Conformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice " ;
  Pubmed PMID: 33507292.
• Extracellular Vimentin/VWF (von Willebrand Factor) Interaction Contributes to VWF String Formation and Stroke Pathology " ;
  Pubmed PMID: 30355099.
• Thromboelastographic Results and Hypercoagulability Syndrome in Patients With Coronavirus Disease 2019 Who Are Critically Ill " ;
  Pubmed PMID: 32501489.

Show 5 more publications

Memberships

International Society of Hemostasis and Thrombosis

Funding

Microvascular Thrombosis in systemic inflammation
#R01GM112806

$1,522,000.00   (09/25/2014 - 05/31/2025)

Grant funding from NIH

Molecular Studies of Hemolytic Thrombosis
#R01HL154688

$1,880,000.00   (05/14/2021 - 04/30/2025)

Grant funding from NIH

Collaborative Research Training in Thrombosis and Inflammation

$1,693,400.00   (08/01/2018 - 07/31/2023)

Grant funding from NIH

Intellectual Property

Treatment of medical condition with A2 domain of von Willebrand factor

Product Patent #7879793 (Approved)

Languages

Spanish