Positions
- Professor
-
Medicine
Thrombosis
Baylor College of Medicine
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Research Health Scientist
-
RSL
Michael E. DeBakey VA Medical Center
Houston, Texas United States
Addresses
- MEDVAMC (Lab)
-
2002 Holcombe Blvd.
Building 109
Houston, TX 77030
United States
Phone: (713) 794-7775
miguelc@bcm.edu
- MEDVAMC (Office)
-
2002 Holcombe Blvd.
Building 109
Houston, TX 77030
United States
Phone: (713) 794-7775
miguelc@bcm.edu
Education
- PhD from University Of Puerto Rico School Of Medicine, Rio Piedras, Pr
- 01/1989 - Rio Piedras, PR
- Biochemistry
- Postdoctoral Fellowship at Harvard Medical School
- 01/1994 - Boston, Massachusetts United States
- Protein Biochemistry - Hematology
- BS from University Of Puerto Rico, Rio Piedras, Puerto Rico
- Rio Piedras, PR
- Chemistry
- Advanced Training from Brigham And Women's Hospital
- 01/1994 - Boston, MA United States
Professional Interests
- Thrombosis, von Willebrand factor, platelet adhesion, DIC, extracellular hemoglobin, inflammation, vimentin, tranlational medicine
Websites
Department of Medicine - Division of Thrombosis Research
Selected Publications
- Da Q, Teruya M, Guchhait P, Teruya J, Olson JS, Cruz MA. "Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications on circulatory devices.." Blood. 2015 : Pubmed PMID: 26307534
- Nguyen, TC, Gushiken, F, Correa, JI, Dong, J-F, Dasgupta, SK, Thiagarajan, P, Cruz, M.A. "A recombinant fragment of von Willebrand factor reduces fibrin-rich microthrombi formation in mice with endotoxemia.." Thromb Res.. 2015 May ; 135 : Pubmed PMID: 25769494
- Qi Da, Molly Behymer, Juliana I. Correa, K. Vinod Vijayan, and Miguel A. Cruz. "Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress.." Blood. 2014 123 : Pubmed PMID: 24642750
- "Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation." : Pubmed PMID: 32259201
- "The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium." : Pubmed PMID: 33048962
- "Links between thrombosis and inflammation in traumatic brain injury." : Pubmed PMID: 33290884
- "Conformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice." : Pubmed PMID: 33507292
- "Extracellular Vimentin/VWF (von Willebrand Factor) Interaction Contributes to VWF String Formation and Stroke Pathology." : Pubmed PMID: 30355099
- "Thromboelastographic Results and Hypercoagulability Syndrome in Patients With Coronavirus Disease 2019 Who Are Critically Ill." : Pubmed PMID: 32501489
Memberships
- International Society of Hemostasis and Thrombosis
Funding
- Role of vimentin in thrombosis and stroke - #R01NS094280
- $1,290,000.00 (09/01/2016 - 06/30/2021) Grant funding from NIH
- Molecular Studies of Hemolytic Thrombosis - #R01HL154688
- $1,880,000.00 (05/14/2021 - 04/30/2025) Grant funding from NIH
Intellectual Property
- Product Patent #7879793 (Approved)
Languages
Spanish
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