Positions
- Professor
-
Medicine
Thrombosis
Baylor College of Medicine
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Research Health Scientist
-
RSL
Michael E. DeBakey VA Medical Center
Houston, Texas United States
Addresses
- MEDVAMC (Lab)
-
2002 Holcombe Blvd.
Building 109
Houston, TX 77030
United States
(713) 794-7775
miguelc@bcm.edu
- MEDVAMC (Office)
-
2002 Holcombe Blvd.
Building 109
Houston, TX 77030
United States
(713) 794-7775
miguelc@bcm.edu
Education
- PhD from University Of Puerto Rico School Of Medicine, Rio Piedras, Pr
- 01/1989 - Rio Piedras, PR
- Biochemistry
- Postdoctoral Fellowship at Harvard Medical School
- 01/1994 - Boston, Massachusetts United States
- Protein Biochemistry - Hematology
- BS from University Of Puerto Rico, Rio Piedras, Puerto Rico
- Rio Piedras, PR
- Chemistry
- Advanced Training from Brigham And Women's Hospital
- 01/1994 - Boston, MA United States
Professional Interests
- Thrombosis, von Willebrand factor, platelet adhesion, DIC, extracellular hemoglobin, inflammation, vimentin, tranlational medicine
Websites
Department of Medicine - Division of Thrombosis Research
Selected Publications
- Nguyen TC, Cruz MA, Carcillo JA. "Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury.." Crit Care Clin.. 2015 : Pubmed PMID: 26410136
- Da Q, Teruya M, Guchhait P, Teruya J, Olson JS, Cruz MA. "Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications on circulatory devices.." Blood. 2015 : Pubmed PMID: 26307534
- Nguyen, TC, Gushiken, F, Correa, JI, Dong, J-F, Dasgupta, SK, Thiagarajan, P, Cruz, M.A. "A recombinant fragment of von Willebrand factor reduces fibrin-rich microthrombi formation in mice with endotoxemia.." Thromb Res.. 2015 May ; 135 : Pubmed PMID: 25769494
- Qi Da, Molly Behymer, Juliana I. Correa, K. Vinod Vijayan, and Miguel A. Cruz. "Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress.." Blood. 2014 123 : Pubmed PMID: 24642750
- Auton M, Sowa KE, Behymer M, Cruz MA "N-terminal Flanking Region of A1 Domain in von Willebrand Factor Stabilizes Structure of A1A2A3 Complex and Modulates Platelet Activation under Shear Stress.." J. Biol. Chem.. 2012 April 27; 287 (18): 14579-85. Pubmed PMID: 22431729
- Auton M, Sowa KE, Smith SM, Sedlák E, Vijayan KV, Cruz MA "Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress.." J. Biol. Chem.. 2010 July 23; 285 (30): 22831-9. Pubmed PMID: 20498367
- Schulte am Esch J, Cruz MA, Siegel JB, Anrather J, Robson SC "Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor.." Blood. 1997 December 1; 90 (11): 4425-37. Pubmed PMID: 9373253
- Whitelock JL, Nolasco L, Bernardo A, Moake J, Dong JF, Cruz MA "ADAMTS-13 activity in plasma is rapidly measured by a new ELISA method that uses recombinant VWF-A2 domain as substrate.." J. Thromb. Haemost.. 2004 March ; 2 (3): 485-91. Pubmed PMID: 15009467
- Dong JF, Moake JL, Bernardo A, Fujikawa K, Ball C, Nolasco L, López JA, Cruz MA "ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor.." J. Biol. Chem.. 2003 August 8; 278 (32): 29633-9. Pubmed PMID: 12775718
- Lasser G, Guchhait P, Ellsworth JL, Sheppard P, Lewis K, Bishop P, Cruz MA, Lopez JA, Fruebis J "C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen.." Blood. 2006 January 15; 107 (2): 423-30. Pubmed PMID: 16195328
- Auton M, Sedlák E, Marek J, Wu T, Zhu C, Cruz MA "Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha.." Biophys. J.. 2009 July 22; 97 (2): 618-27. Pubmed PMID: 19619477
- Auton M, Cruz MA, Moake J "Conformational stability and domain unfolding of the Von Willebrand factor A domains.." J. Mol. Biol.. 2007 February 23; 366 (3): 986-1000. Pubmed PMID: 17187823
Memberships
- International Society of Hemostasis and Thrombosis
Funding
- Role of vimentin in thrombosis and stroke - #R01NS094280
- $1,290,000.00 (09/01/2016 - 06/30/2021) Grant funding from NIH
Intellectual Property
- Product Patent #7879793 (Approved)
Languages
Spanish
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