Positions

Professor
Pediatrics-Hem-Onc Cell & Gene
Baylor College of Medicine
Houston, TX, US
Professor
Pediatrics
Baylor College of Medicine
Professor
Molecular and Human Genetics
Baylor College of Medicine
Professor
Program in Integrative Molecular and Biomedical Sciences
Baylor College of Medicine
Professor
Program in Developmental Biology
Baylor College of Medicine
Professor
Program in Translational Biology & Molecular Medicine
Baylor College of Medicine
Professor
Stem Cells and Regenerative Medicine (STaR) Center
Baylor College of Medicine
Vivian L. Smith Chair in Regenerative Medicine
Baylor College of Medicine
Houston, Texas, United States
Co-Leader, Cancer Cell and Gene Therapy
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

BS from Imperial College, United Kingdom
PhD from University Of Cambridge
Post-Doctoral Fellowship at Whitehead Institute, M.I.T.
Post-Doctoral Fellowship at Harvard Medical School

Professional Interests

  • Murine and human hematopoietic stem cells
  • Genetic and epigenetic regulation and development.

Professional Statement

Murine and human hematopoietic stem cells; genetic and epigenetic regulation and development.

We are interested in the basic biology of hematopoietic stem cells. It has been known for decades that hematopoietic stem cells reside in the bone marrow in a quiescent state and replenish the supply of differentiated cells of the peripheral blood throughout the lifetime of an animal. No other adult cell type retains the capacity for such immense proliferation and differentiation. However, little is known about the cells or factors that regulate their primitive state or control their activation. We study the behavior of these stem cells in vivo and in vitro using mouse stem cells as a model, as well as pursue the mechanisms which control their behavior on a molecular level using genome-wide profiling strategies and mouse mutants.

Selected Publications