Jeffrey M Rosen, Ph.D.

Distinguished Service Professor

(713) 798-6210

Email

jrosen@bcm.edu

Positions

Distinguished Service Professor: Mol & Cell Biology-Rosen
Baylor College of Medicine
Houston, TX, US

Leader, Breast Cancer Program: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Professor: Baylor College of Medicine

Charles C. Bell Professor: Molecular and Cellular Biology

Addresses

Department of Molecular and Cellular Biology (Office): Baylor College of Medicine
One Baylor Plaza N610
Houston, TX, 77030
United States
Phone: (832) 215-9503
jrosen@bcm.edu

Education

BA from Williams College: 01/1966 - Williamstown, Massachusetts, United States

PhD from State University of New York at Buffalo: 01/1970 - Buffalo, New York, United States

Post-Doctoral Fellowship at Vanderbilt University School of Medicine: 01/1972 - Nashville, Tennessee, United States

Honors & Awards

Marc Dresden Excellence in Graduate Education Award, 1996

Endocrine Society Edwin B. Astwood Lecture Award 2000

Barbara & Corbin J. Robertson, Jr. Presidential Award for Excellence in Education, Baylor College of Medicine, 2002

Michael E. DeBakey, M.D., Excellence in Research Award, 2004.

Susan G. Komen for the Cure® Brinker Basic Science Award, 2010

AAAS Fellow, 2016

AACR Distinguished Lectureship in Breast Cancer Research, 2017

AACR/SABCS William A McGuire Memorial Lecture Award: AACR/SABCS (12/2022)

Professional Interests

Developmental and hormonal regulation of mammary gland gene expression and breast cancer

Professional Statement

Our laboratory has developed a series of extensively characterized and "credentialed" syngeneic models of triple negative breast cancer that are being used in preclinical studies to determine both tumor intrinsic and extrinsic effects on the tumor microenvironment of both targeted therapies using small molecular inhibitors as well as gapmer antisense oligonucleotides. These studies are focused on combinatorial treatment strategies with standard-of care chemotherapy and immunotherapy of both primary tumors and established metastases with the long-term goal of translating these studies into the clinic.

Websites

Rosen Laboratory

VIICTR Publications List

Selected Publications

Kim, IS, Welte, T, Gao, Y, Toneff, MJ, Wang, H, Janghorban, M, Zhao, N, Goldstein, A, Sheng, K, Niu, Y, Liu, J, Lo, H-C, Bado, I, Nguyen, T, et al. and Rosen, JM, Zhang, X H-F.. " Immuno-subtyping of breast cancer reveals distinct myeloid cell biology and immunotherapy resistance mechanisms " Nature Cell Biol. 2019 ; 21 : 1113-1126.
Pubmed PMID: 31451770.
Nguyen, TM, Kabotyanski, EB, Dou, Y, Reineke, LC, Zhang, P, Zhang, X, Malovannaya, A, Jung, SY, Mo, Q, Roarty, K, Chen, Y, Zhang, B, Neilson, JR, Lloyd, RE, Perou, CM, Ellis, MJ and Rosen, JM.. " FGFR1-activated translation of WNT pathway components with structured 5’ UTRs is vulnerable to inhibition of eIF4A-dependent translation initiation " Cancer Res. 2018 ; 78 : 4229-4240.
Pubmed PMID: 29844125.
Sreekumar A, Toneff MJ, Toh E, Roarty K, Creighton CJ, Belka GK, Lee DK, Xu J, Chodosh LA, Richards JS, Rosen JM. " WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis " Dev Cell. 2017 ; 43 : 436-448.
Pubmed PMID: 29103953.
Welte, T., Kim, IS, Tian, L, Gao, X, Wang, H., Li, J. Holdman, X.B., Herschkowitz, J.I., Pond, A., Xie, G., Kurley, S, Nguyen, T, et al and Westbrook, T, Rosen, JM. and Zhang, XH. " Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation " Nature Cell Biol. 2016 ; 18 : 632-644.
Pubmed PMID: 27183469.
Zhang, M, Tsimelzon, A, Chang, C-H, Fan, C., Wolff, A, Perou, CM, Hilsenbeck, SG and Rosen, JM. " Intratumoral heterogeneity in a Trp53-null mouse model of human breast cancer " Cancer Discovery. 2015 ; 5 : 520-533.
Pubmed PMID: 25735774.
Roarty, K, Shore, AN, Creighton, CJ, and Rosen, JM. " Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics with the mammary epithelium. " J Cell Biol. 2015 ; 208 : 351-366.
Pubmed PMID: 25624393.
Hollier BG, Tinnirello AA, Werden SJ, Evans KW, Taube JH, Sarkar TR, Sphyris N, Shariati M, Kumar SV, Battula VL, Herschkowitz JI, Guerra R, Chang JT, Miura N, Rosen JM, Mani SA. " FOXC2 Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Breast Cancer. " Cancer Res.. 2013 Mar 15; 73 (6) : 1981-92.
Pubmed PMID: 23378344.
Machado HL, Kittrell FS, Edwards D, White AN, Atkinson RL, Rosen JM, Medina D, Lewis MT. " Separation by cell size enriches for mammary stem cell repopulation activity. " Stem Cells Transl Med. 2013 Mar ; 2 (3) : 199-203.
Pubmed PMID: 23408103.
Rosen JM. " On hormone action in the mammary gland. " Cold Spring Harb Perspect Biol. 2012 ; 4 (2)
Pubmed PMID: 22300979.
Shahi P, Park D, Pond AC, Seethammagari M, Chiou SH, Cho K, Carstens JL, Decker WK, McCrea PD, Ittmann MM, Rosen JM, Spencer DM. " Activation of Wnt Signaling by Chemically Induced Dimerization of LRP5 Disrupts Cellular Homeostasis. " PLoS ONE. 2012 ; 7 (1) : e30814.
Pubmed PMID: 22303459.
Rosen JM. " On murine mammary epithelial stem cells: discovery, function, and current status. " Cold Spring Harb Perspect Biol. 2012 ; 4 (4)
Pubmed PMID: 22474010.
Shore AN, Kabotyanski EB, Roarty K, Smith MA, Zhang Y, Creighton CJ, Dinger ME, Rosen JM. " Pregnancy-Induced Noncoding RNA (PINC) Associates with Polycomb Repressive Complex 2 and Regulates Mammary Epithelial Differentiation. " PLoS Genet.. 2012 Jul ; 8 (7) : e1002840.
Pubmed PMID: 22911650.
Contreras A, Hale TK, Stenoien DL, Rosen JM, Mancini MA, Herrera RE. " The dynamic mobility of histone H1 is regulated by cyclin/CDK phosphorylation. " Mol. Cell. Biol.. 2003 Dec ; 23 (23) : 8626-36.
Pubmed PMID: 14612406.
Rainusso N, Brawley VS, Ghazi A, Hicks MJ, Gottschalk S, Rosen JM, Ahmed N. " Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma. " Cancer Gene Ther.. 2012 Mar ; 19 (3) : 212-7.
Pubmed PMID: 22173710.
Behbod F, Rosen JM. " Mammary Gland Development & Breast Cancer; Connecting the Dots by Non-Coding RNAs. " J Mammary Gland Biol Neoplasia. 2012 Mar ; 17 (1) : 41276.
Pubmed PMID: 22402939.
Shore AN, Herschkowitz JI, Rosen JM. " Noncoding RNAs Involved in Mammary Gland Development and Tumorigenesis: There's a Long Way to Go. " J Mammary Gland Biol Neoplasia. 2012 Mar ; 17 (1) : 43-58.
Pubmed PMID: 22402938.
Zhang L, Zhang B, Han SJ, Shore AN, Rosen JM, Demayo FJ, Xin L. " Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis. " 2012 Feb 15;
Pubmed PMID: 22350718.
Kittrell FS, Carletti MZ, Kerbawy S, Heestand J, Xian W, Zhang M, Lamarca HL, Sonnenberg A, Rosen JM, Medina D, Behbod F. " Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential. " Breast Cancer Res.. 2011 ; 13 (2) : R41.
Pubmed PMID: 21466693.
Batts TD, Machado HL, Zhang Y, Creighton CJ, Li Y, Rosen JM. " Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration. " PLoS ONE. 2011 ; 6 (11) : e27841.
Pubmed PMID: 22140470.
Heckman-Stoddard BM, Vargo-Gogola T, Herrick MP, Visbal AP, Lewis MT, Settleman J, Rosen JM. " P190A RhoGAP is required for mammary gland development. " Dev. Biol.. 2011 Dec 1; 360 (1) : 41284.
Pubmed PMID: 21945077.
Rainusso N, Man TK, Lau CC, Hicks J, Shen JJ, Yu A, Wang LL, Rosen JM. " Identification and gene expression profiling of tumor-initiating cells isolated from human osteosarcoma cell lines in an orthotopic mouse model. " Cancer Biol. Ther.. 2011 Aug 15; 12 (4) : 278-87.
Pubmed PMID: 21617384.
Buser AC, Obr AE, Kabotyanski EB, Grimm SL, Rosen JM, Edwards DP. " Progesterone Receptor Directly Inhibits {beta}-Casein Gene Transcription in Mammary Epithelial Cells Through Promoting Promoter and Enhancer Repressive Chromatin Modifications. " Mol. Endocrinol.. 2011 Jun ; 25 (6) : 955-68.
Pubmed PMID: 21527503.
Wei Z, Peddibhotla S, Lin H, Fang X, Li M, Rosen JM, Zhang P. " Early-onset aging and defective DNA damage response in cdc14b-deficient mice. " Mol. Cell. Biol.. 2011 Apr ; 31 (7) : 1470-7.
Pubmed PMID: 21262768.
Visbal AP, Lamarca HL, Villanueva H, Toneff MJ, Li Y, Rosen JM, Lewis MT. " Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened. " Dev. Biol.. 2011 Apr 1; 352 (1) : 116-27.
Pubmed PMID: 21276786.
Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ. " The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. " Proc. Natl. Acad. Sci. U.S.A.. 2011 Mar 1; 108 (9) : 3665-70.
Pubmed PMID: 21307310.
Peddibhotla S, Wei Z, Papineni R, Lam MH, Rosen JM, Zhang P. " The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression. " Cell Cycle. 2011 Feb 15; 10 (4) : 671-9.
Pubmed PMID: 21301228.
Boles NC, Peddibhotla S, Chen AJ, Goodell MA, Rosen JM. " Chk1 haploinsufficiency results in anemia and defective erythropoiesis. " PLoS ONE. 2010 ; 5 (1) : e8581.
Pubmed PMID: 20052416.
Roarty K, Rosen JM. " Wnt and mammary stem cells: hormones cannot fly wingless. " Curr Opin Pharmacol. 2010 Dec ; 10 (6) : 643-9.
Pubmed PMID: 20810315.
Dong J, Tong T, Reynado AM, Rosen JM, Huang S, Li Y. " Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones. " Dev. Biol.. 2010 Oct 15; 346 (2) : 196-203.
Pubmed PMID: 20691178.
Atkinson RL, Zhang M, Diagaradjane P, Peddibhotla S, Contreras A, Hilsenbeck SG, Woodward WA, Krishnan S, Chang JC, Rosen JM. " Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy. " Sci Transl Med. 2010 Oct 27; 2 (55) : 55ra79.
Pubmed PMID: 20980696.
McHenry PR, Sears JC, Herrick MP, Chang P, Heckman-Stoddard BM, Rybarczyk M, Chodosh LA, Gunther EJ, Hilsenbeck SG, Rosen JM, Vargo-Gogola T. " P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. " Breast Cancer Res.. 2010 Sep 22; 12 (5) : R73.
Pubmed PMID: 20860838.
Greene SB, Herschkowitz JI, Rosen JM. " Small Players With Big Roles: MicroRNAs As Targets To Inhibit Breast Cancer Progression. " Curr Drug Targets. 2010 Sep 1; 11 (9) : 1059-73.
Pubmed PMID: 20545613.
Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, Hollier BG, Ram PT, Lander ES, Rosen JM, Weinberg RA, Mani SA. " Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. " Proc. Natl. Acad. Sci. U.S.A.. 2010 Aug 31; 107 (35) : 15449-54.
Pubmed PMID: 20713713.
Reddy JP, Peddibhotla S, Bu W, Zhao J, Haricharan S, Du YC, Podsypanina K, Rosen JM, Donehower LA, Li Y. " Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. " Proc. Natl. Acad. Sci. U.S.A.. 2010 Feb 23; 107 (8) : 3728-33.
Pubmed PMID: 20133707.
Heckman-Stoddard BM, Vargo-Gogola T, McHenry PR, Jiang V, Herrick MP, Hilsenbeck SG, Settleman J, Rosen JM. " Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression. " Breast Cancer Res.. 2009 ; 11 (4) : R61.
Pubmed PMID: 19703301.
Behbod F, Kittrell FS, LaMarca H, Edwards D, Kerbawy S, Heestand JC, Young E, Mukhopadhyay P, Yeh HW, Allred DC, Hu M, Polyak K, Rosen JM, Medina D. " An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. " Breast Cancer Res.. 2009 ; 11 (5) : R66.
Pubmed PMID: 19735549.
Rosen, J.M. and Jordan, C.T. " The increasing complexity of the cancer stem cell paradigm " Science. 2009 ; 324 : 1670-1673.
Pubmed PMID: 19556499.
Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, Rimm DL, Wong H, Rodriguez A, Herschkowitz JI, Fan C, Zhang X, He X, Pavlick A, Gutierrez MC, Renshaw L, Larionov AA, Faratian D, Hilsenbeck SG, Perou CM, Lewis MT, Rosen JM, Chang JC. " Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. " Proc. Natl. Acad. Sci. U.S.A.. 2009 Aug 18; 106 (33) : 13820-5.
Pubmed PMID: 19666588.
Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, Edwards D, Medina D, Tsimelzon A, Hilsenbeck S, Green JE, Michalowska AM, Rosen JM. " Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. " Cancer Res.. 2008 Jun 15; 68 (12) : 4674-82.
Pubmed PMID: 18559513.
Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, Hilsenbeck SG, Pavlick A, Zhang X, Chamness GC, Wong H, Rosen J, Chang JC. " Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. " J. Natl. Cancer Inst.. 2008 May 7; 100 (9) : 672-9.
Pubmed PMID: 18445819.
Xian W, Pappas L, Pandya D, Selfors LM, Derksen PW, de Bruin M, Gray NS, Jonkers J, Rosen JM, Brugge JS. " Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival. " Cancer Res.. 2009 Mar 15; 69 (6) : 2244-51.
Pubmed PMID: 19258500.
Vargo-Gogola, T and Rosen, JM. " Modeling breast cancer. One size does not fit all " Nature Rev Cancer. 2007 ; 7 : 659-672.
Pubmed PMID: 17721431.
Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM. " Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. " Dev. Biol.. 2007 Sep 1; 309 (1) : 137-49.
Pubmed PMID: 17662267.
Mukhopadhyay SS, Rosen JM. " The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells. " Biochem. Biophys. Res. Commun.. 2007 Jul 6; 358 (3) : 770-6.
Pubmed PMID: 17511965.
Chen MS, Woodward WA, Behbod F, Peddibhotla S, Alfaro MP, Buchholz TA, Rosen JM. " Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line. " J. Cell. Sci.. 2007 Feb 1; 120 : 468-77.
Pubmed PMID: 17227796.
Buser AC, Gass-Handel EK, Wyszomierski SL, Doppler W, Leonhardt SA, Schaack J, Rosen JM, Watkin H, Anderson SM, Edwards DP. " Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells. " Mol. Endocrinol.. 2007 Jan ; 21 (1) : 106-25.
Pubmed PMID: 16973758.
Woodward WA, Chen MS, Behbod F, Alfaro MP, Buchholz TA, Rosen JM. " WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. " Proc. Natl. Acad. Sci. U.S.A.. 2007 Jan 9; 104 (2) : 618-23.
Pubmed PMID: 17202265.
Grimm SL, Bu W, Longley MA, Roop DR, Li Y, Rosen JM. " Keratin 6 is not essential for mammary gland development. " Breast Cancer Res.. 2006 ; 8 (3) : R29.
Pubmed PMID: 16790075.
Kabotyanski EB, Huetter M, Xian W, Rijnkels M, Rosen JM. " Integration of prolactin and glucocorticoid signaling at the beta-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiers. " Mol. Endocrinol.. 2006 Oct ; 20 (10) : 2355-68.
Pubmed PMID: 16772529.
Cella N, Contreras A, Latha K, Rosen JM, Zhang M. " Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells. " FASEB J.. 2006 Jul ; 20 (9) : 1510-2.
Pubmed PMID: 16720730.
Schwertfeger KL, Xian W, Kaplan AM, Burnett SH, Cohen DA, Rosen JM. " A critical role for the inflammatory response in a mouse model of preneoplastic progression. " Cancer Res.. 2006 Jun 1; 66 (11) : 5676-85.
Pubmed PMID: 16740705.
Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM. " P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland. " Mol. Endocrinol.. 2006 Jun ; 20 (6) : 1391-405.
Pubmed PMID: 16469769.
Ginger MR, Shore AN, Contreras A, Rijnkels M, Miller J, Gonzalez-Rimbau MF, Rosen JM. " A noncoding RNA is a potential marker of cell fate during mammary gland development. " Proc. Natl. Acad. Sci. U.S.A.. 2006 Apr 11; 103 (15) : 5781-6.
Pubmed PMID: 16574773.
Behbod F, Xian W, Shaw CA, Hilsenbeck SG, Tsimelzon A, Rosen JM. " Transcriptional profiling of mammary gland side population cells. " Stem Cells. 2006 Apr ; 24 (4) : 1065-74.
Pubmed PMID: 16282442.
Xian W, Schwertfeger KL, Vargo-Gogola T, Rosen JM. " Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model. " J. Cell Biol.. 2005 Nov 21; 171 (4) : 663-73.
Pubmed PMID: 16301332.
Grimm SL, Contreras A, Barcellos-Hoff MH, Rosen JM. " Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice. " J. Biol. Chem.. 2005 Oct 28; 280 (43) : 36301-9.
Pubmed PMID: 16120603.
Lam MH, Liu Q, Elledge SJ, Rosen JM. " Chk1 is haploinsufficient for multiple functions critical to tumor suppression. " Cancer Cell. 2004 Jul ; 6 (1) : 45-59.
Pubmed PMID: 15261141.
Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE. " Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. " Proc. Natl. Acad. Sci. U.S.A.. 2003 Dec 23; 100 (26) : 15853-8.
Pubmed PMID: 14668450.
Freeman KW, Welm BE, Gangula RD, Rosen JM, Ittmann M, Greenberg NM, Spencer DM. " Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice. " Cancer Res.. 2003 Dec 1; 63 (23) : 8256-63.
Pubmed PMID: 14678983.
Hernandez I, Maddison LA, Wei Y, DeMayo F, Petras T, Li B, Gingrich JR, Rosen JM, Greenberg NM. " Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival. " Mol. Cancer Res.. 2003 Dec ; 1 (14) : 1036-47.
Pubmed PMID: 14707287.
Freeman KW, Gangula RD, Welm BE, Ozen M, Foster BA, Rosen JM, Ittmann M, Greenberg NM, Spencer DM. " Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation. " Cancer Res.. 2003 Oct 1; 63 (19) : 6237-43.
Pubmed PMID: 14559809.
Rijnkels M, Elnitski L, Miller W, Rosen JM. " Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteins. " Genomics. 2003 Oct ; 82 (4) : 417-32.
Pubmed PMID: 13679022.
Rosen JM. " Striking it rich by data mining. " Cell. 2003 Aug 8; 114 (3) : 271-2.
Pubmed PMID: 12914689.
Lee AV, Zhang P, Ivanova M, Bonnette S, Oesterreich S, Rosen JM, Grimm S, Hovey RC, Vonderhaar BK, Kahn CR, Torres D, George J, Mohsin S, Allred DC, Hadsell DL. " Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland. " Endocrinology. 2003 Jun ; 144 (6) : 2683-94.
Pubmed PMID: 12746333.
Chakravarty G, Hadsell D, Buitrago W, Settleman J, Rosen JM. " p190-B RhoGAP regulates mammary ductal morphogenesis. " Mol. Endocrinol.. 2003 Jun ; 17 (6) : 1054-65.
Pubmed PMID: 12637587.
Kabotyanski EB, Rosen JM. " Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b. " J. Biol. Chem.. 2003 May 9; 278 (19) : 17218-27.
Pubmed PMID: 12621061.
Pownall ME, Welm BE, Freeman KW, Spencer DM, Rosen JM, Isaacs HV. " An inducible system for the study of FGF signalling in early amphibian development. " Dev. Biol.. 2003 Apr 1; 256 (1) : 89-99.
Pubmed PMID: 12654294.
Tepera SB, McCrea PD, Rosen JM. " A beta-catenin survival signal is required for normal lobular development in the mammary gland. " J. Cell. Sci.. 2003 Mar 15; 116 : 1137-49.
Pubmed PMID: 12584256.
Medina D, Kittrell FS, Shepard A, Contreras A, Rosen JM, Lydon J. " Hormone dependence in premalignant mammary progression. " Cancer Res.. 2003 Mar 1; 63 (5) : 1067-72.
Pubmed PMID: 12615724.
Grimm SL, Seagroves TN, Kabotyanski EB, Hovey RC, Vonderhaar BK, Lydon JP, Miyoshi K, Hennighausen L, Ormandy CJ, Lee AV, Stull MA, Wood TL, Rosen JM. " Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. " Mol. Endocrinol.. 2002 Dec ; 16 (12) : 2675-91.
Pubmed PMID: 12456789.
Kingsley-Kallesen M, Mukhopadhyay SS, Wyszomierski SL, Schanler S, Schütz G, Rosen JM. " The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development. " Mol. Endocrinol.. 2002 Sep ; 16 (9) : 2008-18.
Pubmed PMID: 12198239.
Welm BE, Freeman KW, Chen M, Contreras A, Spencer DM, Rosen JM. " Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland. " J. Cell Biol.. 2002 May 13; 157 (4) : 703-14.
Pubmed PMID: 12011115.
Welm BE, Tepera SB, Venezia T, Graubert TA, Rosen JM, Goodell MA. " Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. " Dev. Biol.. 2002 May 1; 245 (1) : 42-56.
Pubmed PMID: 11969254.
Shillingford JM, Miyoshi K, Robinson GW, Grimm SL, Rosen JM, Neubauer H, Pfeffer K, Hennighausen L. " Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium. " Mol. Endocrinol.. 2002 Mar ; 16 (3) : 563-70.
Pubmed PMID: 11875116.
Ginger MR, Gonzalez-Rimbau MF, Gay JP, Rosen JM. " Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland. " Mol. Endocrinol.. 2001 Nov ; 15 (11) : 1993-2009.
Pubmed PMID: 11682629.
Miyoshi K, Shillingford JM, Smith GH, Grimm SL, Wagner KU, Oka T, Rosen JM, Robinson GW, Hennighausen L. " Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. " J. Cell Biol.. 2001 Nov 12; 155 (4) : 531-42.
Pubmed PMID: 11706048.
Mukhopadhyay SS, Wyszomierski SL, Gronostajski RM, Rosen JM. " Differential interactions of specific nuclear factor I isoforms with the glucocorticoid receptor and STAT5 in the cooperative regulation of WAP gene transcription. " Mol. Cell. Biol.. 2001 Oct ; 21 (20) : 6859-69.
Pubmed PMID: 11564870.
Rijnkels M, Rosen JM. " Adenovirus-Cre-mediated recombination in mammary epithelial early progenitor cells. " J. Cell. Sci.. 2001 Sep ; 114 : 3147-53.
Pubmed PMID: 11590241.
Zahnow CA, Cardiff RD, Laucirica R, Medina D, Rosen JM. " A role for CCAAT/enhancer binding protein beta-liver-enriched inhibitory protein in mammary epithelial cell proliferation. " Cancer Res.. 2001 Jan 1; 61 (1) : 261-9.
Pubmed PMID: 11196172.
Kazansky AV, Rosen JM. " Signal transducers and activators of transcription 5B potentiates v-Src-mediated transformation of NIH-3T3 cells. " Cell Growth Differ.. 2001 Jan ; 12 (1) : 41281.
Pubmed PMID: 11205741.
Murphy KL, Dennis AP, Rosen JM. " A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model. " FASEB J.. 2000 Nov ; 14 (14) : 2291-302.
Pubmed PMID: 11053251.
Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen JM. " P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. " Cell Growth Differ.. 2000 Jul ; 11 (7) : 343-54.
Pubmed PMID: 10939588.
Seagroves TN, Lydon JP, Hovey RC, Vonderhaar BK, Rosen JM. " C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development. " Mol. Endocrinol.. 2000 Mar ; 14 (3) : 359-68.
Pubmed PMID: 10707954.
Hadsell DL, Murphy KL, Bonnette SG, Reece N, Laucirica R, Rosen JM. " Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis. " Oncogene. 2000 Feb 17; 19 (7) : 889-98.
Pubmed PMID: 10702797.
Murphy KL, Rosen JM. " Mutant p53 and genomic instability in a transgenic mouse model of breast cancer. " Oncogene. 2000 Feb 21; 19 (8) : 1045-51.
Pubmed PMID: 10713688.
Rosen JM, Wyszomierski SL, Hadsell D. " Regulation of milk protein gene expression. " Annu. Rev. Nutr.. 1999 ; 19 : 407-36.
Pubmed PMID: 10448531.
Murphy KL, Kittrell FS, Gay JP, Jäger R, Medina D, Rosen JM. " Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice. " Oncogene. 1999 Nov 11; 18 (47) : 6597-604.
Pubmed PMID: 10597264.
Kazansky AV, Kabotyanski EB, Wyszomierski SL, Mancini MA, Rosen JM. " Differential effects of prolactin and src/abl kinases on the nuclear translocation of STAT5B and STAT5A. " J. Biol. Chem.. 1999 Aug 6; 274 (32) : 22484-92.
Pubmed PMID: 10428824.
Seagroves TN, Krnacik S, Raught B, Gay J, Burgess-Beusse B, Darlington GJ, Rosen JM. " C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. " Genes Dev.. 1998 Jun 15; 12 (12) : 1917-28.
Pubmed PMID: 9637692.
Li B, Murphy KL, Laucirica R, Kittrell F, Medina D, Rosen JM. " A transgenic mouse model for mammary carcinogenesis. " Oncogene. 1998 Feb 26; 16 (8) : 997-1007.
Pubmed PMID: 9519874.
Zahnow CA, Younes P, Laucirica R, Rosen JM. " Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer. " J. Natl. Cancer Inst.. 1997 Dec 17; 89 (24) : 1887-91.
Pubmed PMID: 9414177.
Humphreys RC, Rosen JM. " Stably transfected HC11 cells provide an in vitro and in vivo model system for studying Wnt gene function. " Cell Growth Differ.. 1997 Aug ; 8 (8) : 839-49.
Pubmed PMID: 9269893.
Humphreys RC, Lydon J, O'Malley BW, Rosen JM. " Mammary gland development is mediated by both stromal and epithelial progesterone receptors. " Mol. Endocrinol.. 1997 Jun ; 11 (6) : 801-11.
Pubmed PMID: 9171243.
Li B, Rosen JM, McMenamin-Balano J, Muller WJ, Perkins AS. " neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice. " Mol. Cell. Biol.. 1997 Jun ; 17 (6) : 3155-63.
Pubmed PMID: 9154814.
Yarus S, Weaver TE, Rosen JM. " The carboxy-terminal domain of human surfactant protein B is not required for secretion in milk of transgenic mice. " Front. Biosci.. 1997 May 1; 2 : a1-8.
Pubmed PMID: 9206990.
Yarus S, Greenberg NM, Wei Y, Whitsett JA, Weaver TE, Rosen JM. " Secretion of unprocessed human surfactant protein B in milk of transgenic mice. " Transgenic Res.. 1997 Jan ; 6 (1) : 51-7.
Pubmed PMID: 9032978.
Humphreys RC, Krajewska M, Krnacik S, Jaeger R, Weiher H, Krajewski S, Reed JC, Rosen JM. " Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. " Development. 1996 Dec ; 122 (12) : 4013-22.
Pubmed PMID: 9012521.
Yarus S, Rosen JM, Cole AM, Diamond G. " Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice. " Proc. Natl. Acad. Sci. U.S.A.. 1996 Nov 26; 93 (24) : 14118-21.
Pubmed PMID: 8943070.
Raught B, Gingras AC, James A, Medina D, Sonenberg N, Rosen JM. " Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells. " Cancer Res.. 1996 Oct 1; 56 (19) : 4382-6.
Pubmed PMID: 8813130.
Gingrich JR, Barrios RJ, Morton RA, Boyce BF, DeMayo FJ, Finegold MJ, Angelopoulou R, Rosen JM, Greenberg NM. " Metastatic prostate cancer in a transgenic mouse. " Cancer Res.. 1996 Sep 15; 56 (18) : 4096-102.
Pubmed PMID: 8797572.
Hadsell DL, Greenberg NM, Fligger JM, Baumrucker CR, Rosen JM. " Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression. " Endocrinology. 1996 Jan ; 137 (1) : 321-30.
Pubmed PMID: 8536631.
Kazansky AV, Raught B, Lindsey SM, Wang YF, Rosen JM. " Regulation of mammary gland factor/Stat5a during mammary gland development. " Mol. Endocrinol.. 1995 Nov ; 9 (11) : 1598-609.
Pubmed PMID: 8584036.
Li B, Kittrell FS, Medina D, Rosen JM. " Delay of dimethylbenz[a]anthracene-induced mammary tumorigenesis in transgenic mice by apoptosis induced by an unusual mutant p53 protein. " Mol. Carcinog.. 1995 Oct ; 14 (2) : 75-83.
Pubmed PMID: 7576102.
Raught B, Liao WS, Rosen JM. " Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression. " Mol. Endocrinol.. 1995 Sep ; 9 (9) : 1223-32.
Pubmed PMID: 7491114.
Wei Y, Yarus S, Greenberg NM, Whitsett J, Rosen JM. " Production of human surfactant protein C in milk of transgenic mice. " Transgenic Res.. 1995 Jul ; 4 (4) : 232-40.
Pubmed PMID: 7655513.
Krnacik MJ, Li S, Liao J, Rosen JM. " Position-independent expression of whey acidic protein transgenes. " J. Biol. Chem.. 1995 May 12; 270 (19) : 11119-29.
Pubmed PMID: 7744742.
Li S, Rosen JM. " Nuclear factor I and mammary gland factor (STAT5) play a critical role in regulating rat whey acidic protein gene expression in transgenic mice. " Mol. Cell. Biol.. 1995 Apr ; 15 (4) : 2063-70.
Pubmed PMID: 7891701.
Greenberg NM, DeMayo F, Finegold MJ, Medina D, Tilley WD, Aspinall JO, Cunha GR, Donjacour AA, Matusik RJ, Rosen JM. " Prostate cancer in a transgenic mouse. " Proc. Natl. Acad. Sci. U.S.A.. 1995 Apr 11; 92 (8) : 3439-43.
Pubmed PMID: 7724580.
Li S, Rosen JM. " Glucocorticoid regulation of rat whey acidic protein gene expression involves hormone-induced alterations of chromatin structure in the distal promoter region. " Mol. Endocrinol.. 1994 Oct ; 8 (10) : 1328-35.
Pubmed PMID: 7854350.
Li B, Greenberg N, Stephens LC, Meyn R, Medina D, Rosen JM. " Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development. " Cell Growth Differ.. 1994 Jul ; 5 (7) : 711-21.
Pubmed PMID: 7947386.
Li S, Rosen JM. " Distal regulatory elements required for rat whey acidic protein gene expression in transgenic mice. " J. Biol. Chem.. 1994 May 13; 269 (19) : 14235-43.
Pubmed PMID: 8188706.
Raught B, Khursheed B, Kazansky A, Rosen J. " YY1 represses beta-casein gene expression by preventing the formation of a lactation-associated complex. " Mol. Cell. Biol.. 1994 Mar ; 14 (3) : 1752-63.
Pubmed PMID: 8114709.
Coleman-Krnacik S, Rosen JM. " Differential temporal and spatial gene expression of fibroblast growth factor family members during mouse mammary gland development. " Mol. Endocrinol.. 1994 Feb ; 8 (2) : 218-29.
Pubmed PMID: 8170478.
Greenberg NM, DeMayo FJ, Sheppard PC, Barrios R, Lebovitz R, Finegold M, Angelopoulou R, Dodd JG, Duckworth ML, Rosen JM. " The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice. " Mol. Endocrinol.. 1994 Feb ; 8 (2) : 230-9.
Pubmed PMID: 8170479.
Bühler TA, Dale TC, Kieback C, Humphreys RC, Rosen JM. " Localization and quantification of Wnt-2 gene expression in mouse mammary development. " Dev. Biol.. 1993 Jan ; 155 (1) : 87-96.
Pubmed PMID: 8416847.
Wolff J, Wong C, Cheng H, Poyet P, Butel JS, Rosen JM. " Differential effects of the simian virus 40 early genes on mammary epithelial cell growth, morphology, and gene expression. " Exp. Cell Res.. 1992 Sep ; 202 (1) : 67-76.
Pubmed PMID: 1324845.
Dale TC, Krnacik MJ, Schmidhauser C, Yang CL, Bissell MJ, Rosen JM. " High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region. " Mol. Cell. Biol.. 1992 Mar ; 12 (3) : 905-14.
Pubmed PMID: 1545822.
Greenberg NM, Anderson JW, Hsueh AJ, Nishimori K, Reeves JJ, deAvila DM, Ward DN, Rosen JM. " Expression of biologically active heterodimeric bovine follicle-stimulating hormone in milk of transgenic mice. " Proc. Natl. Acad. Sci. U.S.A.. 1991 Oct 1; 88 (19) : 8327-31.
Pubmed PMID: 1924292.
Greenberg NM, Reding TV, Duffy T, Rosen JM. " A heterologous hormone response element enhances expression of rat beta-casein promoter-driven chloramphenicol acetyltransferase fusion genes in the mammary gland of transgenic mice. " Mol. Endocrinol.. 1991 Oct ; 5 (10) : 1504-12.
Pubmed PMID: 1775134.
Goodman HS, Rosen JM. " Transcriptional analysis of the mouse beta-casein gene. " Mol. Endocrinol.. 1990 Nov ; 4 (11) : 1661-70.
Pubmed PMID: 2280771.
Bayna EM, Rosen JM. " Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice. " Nucleic Acids Res.. 1990 May 25; 18 (10) : 2977-85.
Pubmed PMID: 2349094.
Rosen JM, Poyet P, Goodman H, Lee KF. " Mechanisms by which prolactin and glucocorticoids regulate casein gene expression. " Biochem. Soc. Symp.. 1989 ; 55 : 115-23.
Pubmed PMID: 2619762.
Rosen JM, Bayna E, Lee KF. " Analysis of milk protein gene expression in transgenic mice. " Mol. Biol. Med.. 1989 Dec ; 6 (6) : 501-9.
Pubmed PMID: 2699509.
Poyet P, Henning SJ, Rosen JM. " Hormone-dependent beta-casein mRNA stabilization requires ongoing protein synthesis. " Mol. Endocrinol.. 1989 Dec ; 3 (12) : 1961-8.
Pubmed PMID: 2628732.
Dale TC, Rosen JM, Guille MJ, Lewin AR, Porter AG, Kerr IM, Stark GR. " Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription. " EMBO J.. 1989 Mar ; 8 (3) : 831-9.
Pubmed PMID: 2721502.
Lee KF, Atiee SH, Henning SJ, Rosen JM. " Relative contribution of promoter and intragenic sequences in the hormonal regulation of rat beta-casein transgenes. " Mol. Endocrinol.. 1989 Mar ; 3 (3) : 447-53.
Pubmed PMID: 2747652.
Lee KF, Atiee SH, Rosen JM. " Differential regulation of rat beta-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice. " Mol. Cell. Biol.. 1989 Feb ; 9 (2) : 560-5.
Pubmed PMID: 2710117.
Eisenstein RS, Rosen JM. " Both cell substratum regulation and hormonal regulation of milk protein gene expression are exerted primarily at the posttranscriptional level. " Mol. Cell. Biol.. 1988 Aug ; 8 (8) : 3183-90.
Pubmed PMID: 3062379.
Campbell SM, Taha MM, Medina D, Rosen JM. " A clonal derivative of mammary epithelial cell line COMMA-D retains stem cell characteristics of unique morphological and functional heterogeneity. " Exp. Cell Res.. 1988 Jul ; 177 (1) : 109-21.
Pubmed PMID: 2455648.
Yu-Lee LY, Rosen JM. " A transfected alpha-casein minigene bypasses posttranscriptional control by hormones, but retains cell-substratum regulation in mammary epithelial cells. " Mol. Endocrinol.. 1988 May ; 2 (5) : 431-43.
Pubmed PMID: 2458523.
Lee KF, DeMayo FJ, Atiee SH, Rosen JM. " Tissue-specific expression of the rat beta-casein gene in transgenic mice. " Nucleic Acids Res.. 1988 Feb 11; 16 (3) : 1027-41.
Pubmed PMID: 3344200.
Brown TL, Rosen JM. " Isolation and characterization of milk protein nuclear RNAs in rat mammary gland. " Anal. Biochem.. 1986 Mar ; 153 (2) : 211-20.
Pubmed PMID: 2871772.
Yu-Lee LY, Richter-Mann L, Couch CH, Stewart AF, Mackinlay AG, Rosen JM. " Evolution of the casein multigene family: conserved sequences in the 5' flanking and exon regions. " Nucleic Acids Res.. 1986 Feb 25; 14 (4) : 1883-902.
Pubmed PMID: 3952000.
Jones WK, Yu-Lee LY, Clift SM, Brown TL, Rosen JM. " The rat casein multigene family. Fine structure and evolution of the beta-casein gene. " J. Biol. Chem.. 1985 Jun 10; 260 (11) : 7042-50.
Pubmed PMID: 3997858.
Campbell SM, Rosen JM, Hennighausen LG, Strech-Jurk U, Sippel AE. " Comparison of the whey acidic protein genes of the rat and mouse. " Nucleic Acids Res.. 1984 Nov 26; 12 (22) : 8685-97.
Pubmed PMID: 6095207.
Yu-Lee LY, Rosen JM. " The rat casein multigene family. I. Fine structure of the gamma-casein gene. " J. Biol. Chem.. 1983 Sep 10; 258 (17) : 10794-804.
Pubmed PMID: 6309815.
Johnson ML, Levy J, Supowit SC, Yu-Lee LY, Rosen JM. " Tissue- and cell-specific casein gene expression. II. Relationship to site-specific DNA methylation. " J. Biol. Chem.. 1983 Sep 10; 258 (17) : 10805-11.
Pubmed PMID: 6411721.
Johnson ML, Levy J, Rosen JM. " Isolation and characterization of casein-producing and -nonproducing cell populations from 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas. " Cancer Res.. 1983 May ; 43 (5) : 2199-209.
Pubmed PMID: 6187446.
Hennighausen LG, Sippel AE, Hobbs AA, Rosen JM. " Comparative sequence analysis of the mRNAs coding for mouse and rat whey protein. " Nucleic Acids Res.. 1982 Jun 25; 10 (12) : 3733-44.
Pubmed PMID: 6896749.
Hobbs AA, Rosen JM. " Sequence of rat alpha- and gamma-casein mRNAs: evolutionary comparison of the calcium-dependent rat casein multigene family. " Nucleic Acids Res.. 1982 Dec 20; 10 (24) : 8079-98.
Pubmed PMID: 6298707.
Supowit SC, Rosen JM. " Hormonal induction of casein gene expression limited to a small subpopulation of 7,12-dimethylbenz(a)anthracene-induced mammary tumor cells. " Cancer Res.. 1982 Apr ; 42 (4) : 1355-60.
Pubmed PMID: 6800652.
Hobbs AA, Richards DA, Kessler DJ, Rosen JM. " Complex hormonal regulation of rat casein gene expression. " J. Biol. Chem.. 1982 Apr 10; 257 (7) : 3598-605.
Pubmed PMID: 6895895.
Gupta P, Rosen JM, D'Eustachio P, Ruddle FH. " Localization of the casein gene family to a single mouse chromosome. " J. Cell Biol.. 1982 Apr ; 93 (1) : 199-204.
Pubmed PMID: 6896059.
Blackburn DE, Hobbs AA, Rosen JM. " Rat beta casein cDNA: sequence analysis and evolutionary comparisons. " Nucleic Acids Res.. 1982 Apr 10; 10 (7) : 2295-307.
Pubmed PMID: 6283475.
Supowit SC, Rosen JM. " Tumor-specific polyadenylated RNA's from 7,12-dimethylbenz(a)anthracene-induced mammary tumors revealed through hybridization with fractionated single-copy DNA. " Cancer Res.. 1981 Oct ; 41 (10) : 3827-34.
Pubmed PMID: 6169428.
Richards DA, Rodgers JR, Supowit SC, Rosen JM. " Construction and preliminary characterization of the rat casein and alpha-lactalbumin cDNA clones. " J. Biol. Chem.. 1981 Jan 10; 256 (1) : 526-32.
Pubmed PMID: 7005218.
Richards DA, Blackburn DE, Rosen JM. " Restriction enzyme mapping and heteroduplex analysis of the rat milk protein cDNA clones. " J. Biol. Chem.. 1981 Jan 10; 256 (1) : 533-8.
Pubmed PMID: 6256356.
Supowit SC, Rosen JM. " Gene expression in normal and neoplastic mammary tissue. " Biochemistry. 1980 Jul 22; 19 (15) : 3452-60.
Pubmed PMID: 6157399.
Matusik RJ, Rosen JM. " Prolactin regulation of casein gene expression: possible mediators. " Endocrinology. 1980 Jan ; 106 (1) : 252-9.
Pubmed PMID: 6243098.
Guyette WA, Matusik RJ, Rosen JM. " Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression. " Cell. 1979 Aug ; 17 (4) : 1013-23.
Pubmed PMID: 487427.
Dudley JP, Butel JS, Socher SH, Rosen JM. " Detection of mouse mammary tumor virus RNA in BALB/c tumor cell lines of nonviral etiologies. " J. Virol.. 1978 Dec ; 28 (3) : 743-52.
Pubmed PMID: 215778.
Dudley JP, Rosen JM, Butel JS. " Differential expression of poly(A)-adjacent sequences of mammary tumor virus RNA in murine mammary cells. " Proc. Natl. Acad. Sci. U.S.A.. 1978 Dec ; 75 (12) : 5797-801.
Pubmed PMID: 83648.
Vonderhaar BK, Smith GH, Pauley RJ, Rosen JM, Topper YJ. " Difference between mammary epithelial cells from mature virgin and primiparous mice. " Cancer Res.. 1978 Nov ; 38 (11) : 4059-65.
Pubmed PMID: 100213.
Pauley RJ, Rosen JM, Socher SH. " Mammary tumour virus and casein gene transcription during mouse mammary development. " Nature. 1978 Oct 5; 275 (5679) : 455-7.
Pubmed PMID: 211437.
Matusik RJ, Rosen JM. " Prolactin induction of casein mRNA in organ culture. A model system for studying peptide hormone regulation of gene expression. " J. Biol. Chem.. 1978 Apr 10; 253 (7) : 2343-7.
Pubmed PMID: 632273.
Rosen JM, O'Neal DL, McHugh JE, Comstock JP. " Progesterone-mediated inhibition of casein mRNA and polysomal casein synthesis in the rat mammary gland during pregnancy. " Biochemistry. 1978 Jan 24; 17 (2) : 290-7.
Pubmed PMID: 619992.
Rosen JM, Socher SH. " Detection of casein messenger RNA in hormone-dependent mammary cancer by molecular hybridisation. " Nature. 1977 Sep 1; 269 (5623) : 83-6.
Pubmed PMID: 408713.
Rosen JM. " Isolation and characterization of purified rat casein messenger ribonucleic acids. " Biochemistry. 1976 Nov 30; 15 (24) : 5263-71.
Pubmed PMID: 999806.
Rosen JM, Barker SW. " Quantitation of casein messenger ribonucleic acid sequences using a specific complementary DNA hybridization probe. " Biochemistry. 1976 Nov 30; 15 (24) : 5272-80.
Pubmed PMID: 63286.
Woo SL, Rosen JM, Liarakos CD, Choi YC, Busch H, Means AR. " Physical and chemical characterization of purified ovalbumin messenger RNA. " J. Biol. Chem.. 1975 Sep 10; 250 (17) : 7027-39.
Pubmed PMID: 1158896.
Rosen JM, Chan L, Woo SL, Harris SE, Means AR, O'Malley BW. " Effect of estrogen on the synthesis and processing of ovalbumin messenger RNA in the chick oviduct. " Brookhaven Symp. Biol.. 1975 Jul ; (26) : 320-32.
Pubmed PMID: 1192242.
Rosen JM, Woo SL, Comstock JP. " Regulation of casein messenger RNA during the development of the rat mammary gland. " Biochemistry. 1975 Jul ; 14 (13) : 2895-903.
Pubmed PMID: 1148182.
Harris SE, Rosen JM, Means AR, O'Malley BW. " Use of a specific probe for ovalbumin messenger RNA to quantitate estrogen-induced gene transcripts. " Biochemistry. 1975 May 20; 14 (10) : 2072-81.
Pubmed PMID: 50081.
Rosen JM, Woo SL, Holder JW, Means AR, O'Malley BW. " Preparation and preliminary characterization of purified ovalbumin messenger RNA from the hen oviduct. " Biochemistry. 1975 Jan 14; 14 (1) : 69-78.
Pubmed PMID: 1109593.
Woo SL, Harris SE, Rosen JM, Chan L, Sperry PJ, Means AR, O'Malley BW. " Use of Sepharose 4B for preparative scale fractionation of eukaryotic messenger RNA's. " Prep. Biochem.. 1974 ; 4 (6) : 555-72.
Pubmed PMID: 4475423.
Rosen JM, Harris SE, Rosenfeld GC, Liarakos CD, O'Malley BW. " Effect of estrogen on gene expression in the chick oviduct. 3. Hybridization studies with (3H) messenger RNA and (3H) complementary DNA under conditions of DNA excess. " Cell Differ.. 1974 Jul ; 3 (2) : 103-16.
Pubmed PMID: 4136693.
Rosen JM, Liarakos CD, O'Malley BW. " Effect of estrogen on gene expression in the chick oviduct. I. Deoxyribonucleic acid--deoxyribonucleic acid renaturation studies. " Biochemistry. 1973 Jul 17; 12 (15) : 2803-9.
Pubmed PMID: 4719119.
Liarakos CD, Rosen JM, O'Malley BW. " Effect of estrogen on gene expression in the chick oviduct. II. Transcription of chick tritiated unique deoxyribonucleic acid as measured by hybridization in ribonucleic acid excess. " Biochemistry. 1973 Jul 17; 12 (15) : 2809-16.
Pubmed PMID: 4719120.
Wang JJ, Chervinsky DS, Rosen JM. " Comparative biochemical studies of adriamycin and daunomycin in leukemic cells. " Cancer Res.. 1972 Mar ; 32 (3) : 511-5.
Pubmed PMID: 5061305.
Rosen JM, Fina JJ, Milholland RJ, Rosen F. " Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and RNA and protein metabolism in lymphosarcoma P1798. " Cancer Res.. 1972 Feb ; 32 (2) : 350-5.
Pubmed PMID: 5066716.
Rosen JM, Milholland RJ, Rosen F. " A comparison of the effect of glucocorticoids on glucose uptake and hexokinase activity in lymphosarcoma P1798. " Biochim. Biophys. Acta. 1970 Dec 1; 219 (2) : 447-54.
Pubmed PMID: 5537126.
Rosen JM, Rosen F, Milholland RJ, Nichol CA. " Effects of cortisol on DNA metabolism in the sensitive and resistant lines of mouse lymphoma P1798. " Cancer Res.. 1970 Apr ; 30 (4) : 1129-36.
Pubmed PMID: 5504353.
Rosen JM, Fina JR, Milholland J, Rosen F. " Inhibition of glucose uptake in lymphosarcoma P1798 by cortisol and its relationship to the biosynthesis of deoxyribonucleic acid. " J. Biol. Chem.. 1970 Apr 25; 245 (8) : 2074-80.
Pubmed PMID: 5467455.
Singh, S, Lee, N, Pedroza, D, Bado, I, Zhang, L, Aguirre, S, Hamor, C, Shen, Y, Xu, Y, Hu, J, Gao, Y, , Zhao, N, Chen, S-H, Wan, Y-W, Liu, Z, Chang, JT, Hollern, D, Perou, CM, Zhang, X. H-F, and Rosen, JM.. " Chemotherapy coupled to macrophage inhibition induces T-cell and B-cell infiltration and durable regression in triple-negative breast cancer " Cancer Res. 2022 ;
Pubmed PMID: 35442423.