Positions

Professor
Pediatrics-Hem-Onc Cell & Gene
Baylor College of Medicine
Houston, TX, US

Education

Advanced Training from Yale University School Of Medicine
Advanced Training from University Of Birmingham
Advanced Training from University Of Bristol
Ph.D. from University Of Cambridge
B.Sc. from University Of East Anglia

Professional Interests

  • Virus-specific T cells for treatment of viral diseases

Professional Statement

Dr. Rooney's research interests are immunotherapies for virus and non-virus-associated malignancies and diseases. In protocols developed with Drs. Helen Heslop, Malcolm Brenner, Stephen Gottschalk and Catherine Bollard, about 150 patients have received EBV or antigen-specific cytotoxic T-cells. These have prevented and cured EBV-associated lymphoma in BMT recipients produced mixed tumor responses, including complete remissions in patients with relapsed EBV-positive Hodgkin's disease and nasopharyngeal carcinoma and have produced clinical remission in chronic-active EBV infections. In the research laboratory, she is developing methods for the activation and expansion of antigen-specific CTLs for the treatment of non-viral cancers, investigating ways to render CTL resistant to immune evasion strategies used by tumor cells to grow in an immunocompetent host and developing means to induce antigen-specific tolerance.

Selected Publications

Memberships

Baylor College of Medicine Faculty Senate.