Margaret A. Goodell, Ph.D.
Professor and Chair
Positions
- Professor and Chair
-
Department of Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States
- Director
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Stem Cells and Regenerative Medicine Center (STaR)
Baylor College of Medicine
Houston, Texas, United States
- Thomas C. Thompson Chair in Cell Biology
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Department of Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States
- Member
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Center for Cell and Gene Therapy (CAGT)
Baylor College of Medicine
Houston, Texas, United States
- Co-Leader, Cancer Cell and Gene Therapy
-
Dan L. Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States
Addresses
- Baylor College of Medicine (Office)
-
1 Baylor Plaza
MS: BCM130, Room N604
Houston, TX, 77030
United States
Phone: (713) 798-6037
- Assistant: Pon Vongsombath (Office)
-
Houston, TX, 77030
United States
Phone: (713) 798-6037
pon.vongsombath@bcm.edu
Education
- Postdoctoral Fellowship at Harvard Medical School
- 01/1997 - Boston, Massachusetts, United States
- Postdoctoral Fellowship at Whitehead Institute, M.I.T.
- 01/1996 - Cambridge, Massachusetts, United States
- PhD from University of Cambridge
- 01/1991 - Cambridge, United Kingdom
- BS from Imperial College, United Kingdom
- 01/1986 - London, United Kingdom
Professional Interests
- Murine and human hematopoietic stem cells
- Genetic and epigenetic regulation and development
Professional Statement
Murine and human hematopoietic stem cells; genetic and epigenetic regulation and development.
We are interested in the basic biology of hematopoietic stem cells. It has been known for decades that hematopoietic stem cells reside in the bone marrow in a quiescent state and replenish the supply of differentiated cells of the peripheral blood throughout the lifetime of an animal. No other adult cell type retains the capacity for such immense proliferation and differentiation. However, little is known about the cells or factors that regulate their primitive state or control their activation. We study the behavior of these stem cells in vivo and in vitro using mouse stem cells as a model, as well as pursue the mechanisms which control their behavior on a molecular level using genome-wide profiling strategies and mouse mutants.
We are interested in the basic biology of hematopoietic stem cells. It has been known for decades that hematopoietic stem cells reside in the bone marrow in a quiescent state and replenish the supply of differentiated cells of the peripheral blood throughout the lifetime of an animal. No other adult cell type retains the capacity for such immense proliferation and differentiation. However, little is known about the cells or factors that regulate their primitive state or control their activation. We study the behavior of these stem cells in vivo and in vitro using mouse stem cells as a model, as well as pursue the mechanisms which control their behavior on a molecular level using genome-wide profiling strategies and mouse mutants.
Selected Publications
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Kapadia, Williams, Dawson, Watson, Yousefzadeh, Le, Nyamondo, Kodavali, Cagan, Waldvogel, Zhang, De La Fuente, Leongamornlert, Mitchell, Florez, Sosnowski, Aguilar, Martell, Guzman, Harrison, Niedernhofer, King, Campbell, Blundell, Goodell, Nangalia. " Clonal dynamics and somatic evolution of haematopoiesis in mouse " Nature. 2025 May 15; 641 (8063) : 681-689.
Pubmed PMID: 40044850. -
Datar, Khabusheva, Anand, Beale, Sadek, Chen, Potolitsyna, Contesoto, Liu, De La Fuente, Dollinger, Guzman, Martell, Wohlan, Maiti, Short, Yi, Andresen, Gjertsen, Falini, Rau, Brunetti, Sahni, Goodell, Riback. " Disparate Leukemia Mutations Converge on Nuclear Phase-Separated Condensates " Cell. 2025 Dec 11; 188 (25) : 7118-7136.
Pubmed PMID: 41192422. -
Walvogel S, Posey JE, Goodell MA. " Human embryonic genetic mosaicism and its effects on development and disease " Nature Reviews Genetics. 2024 Oct ; 25 (10) : 698-714.
Pubmed PMID: 38605218. -
Zhang, Hsu, Braekeleer, Chen, Patel, Guzman, Martell, Wohlan, Waldvogel, Urya, Tovy, Callen, Murdaugh, Richard, Jansen, Vissers, de Vries, Nussenzweig, Huang, Coarfa, Anastas, Takahashi, Vassiliou, Goodell. " SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells " eLife. 2024 Jun 18; 12 : RPT91611.
Pubmed PMID: 38896450.
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