Email

echang1@bcm.edu

Positions

Professor

Breast Center - Chang, E.
Baylor College of Medicine
Houston, TX, US

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

Advanced Training from Cold Spring Harbor Laboratory

01/1992 - Cold Spring Harbor, NY, United States

Ph.D. from State University Of New York At Buffalo

01/1989 - Buffalo, NY, United States

B.S. from National Taiwan University

01/1981 - Taipei, China, Rep Of Taiwan

Websites

Selected Publications

• Zheng ZY, Cheng CM, Fu XR, Chen LY, Xu L, Terrillon S, Wong ST, Bar-Sagi D, Songyang Z, Chang EC. " CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. " Oncogene. 2012 Oct 25; 31 (43) : 4630-8.
  Pubmed PMID: 22231449.
• Cheng CM, Li H, Gasman S, Huang J, Schiff R, Chang EC. " Compartmentalized Ras Proteins Transform NIH 3T3 Cells with Different Efficiencies. " Mol. Cell. Biol.. 2011 Mar ; 31 (5) : 983-97.
  Pubmed PMID: 21189290.
• Onken B, Wiener H, Philips MR, Chang EC. " Compartmentalized signaling of Ras in fission yeast. " Proc. Natl. Acad. Sci. U.S.A.. 2006 Jun 13; 103 (24) : 9045-50.
  Pubmed PMID: 16754851.
• Chang EC, Barr M, Wang Y, Jung V, Xu HP, Wigler MH. " Cooperative interaction of S. pombe proteins required for mating and morphogenesis. " Cell. 1994 Oct 7; 79 (1) : 131-41.
  Pubmed PMID: 7923372.
• Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC. " Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium. " Oncogene. 2011 Feb 10; 30 (6) : 724-36.
  Pubmed PMID: 20890303.
• Chen CR, Li YC, Chen J, Hou MC, Papadaki P, Chang EC. " Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation. " Proc. Natl. Acad. Sci. U.S.A.. 1999 Jan 19; 96 (2) : 517-22.
  Pubmed PMID: 9892665.
• Cabrera R, Sha Z, Vadakkan TJ, Otero J, Kriegenburg F, Hartmann-Petersen R, Dickinson ME, Chang EC. " Proteasome nuclear import mediated by arc3 can influence efficient DNA damage repair and mitosis in schizosaccharomyces pombe. " Mol. Biol. Cell. 2010 Sep ; 21 (18) : 3125-36.
  Pubmed PMID: 20668161.
• Yen HC, Gordon C, Chang EC. " Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome. " Cell. 2003 Jan 24; 112 (2) : 207-17.
  Pubmed PMID: 12553909.
• Sha Z, Brill LM, Cabrera R, Kleifeld O, Scheliga JS, Glickman MH, Chang EC, Wolf DA. " The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries. " Mol. Cell. 2009 Oct 9; 36 (1) : 141-52.
  Pubmed PMID: 19818717.
• Papadaki P, Pizon V, Onken B, Chang EC. " Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors. " Mol. Cell. Biol.. 2002 Jul ; 22 (13) : 4598-606.
  Pubmed PMID: 12052869.
• Yen HC, Chang EC. " Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation. " Proc. Natl. Acad. Sci. U.S.A.. 2000 Dec 19; 97 (26) : 14370-5.
  Pubmed PMID: 11121040.
• Zheng, Z. Y. Tian, L. Bu, W. Fan, C. Gao, X. Wang, H. Liao, Y. H. Li, Y. Lewis, M. T. Edwards, D. Zwaka, T. P. Hilsenbeck, S. G. Medina, D. Perou, C. M. Creighton, C. J. Zhang, X. H. Chang, E. C.. " Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation " Cell Reports. 2018 ; 12 : 511-524.
  Pubmed PMID: 26166574.
• Zheng ZY, Anurag M, Lei JT, Cao J, Si ... Chen Y, Lavere P, Li J, Du XH, Cakar B, Song W, Kim BJ, Shi J, Seker S, Chan DW, Zhao GQ, Chen X, Banks KC, Lanman RB, Shafaee MN, Zhang XH, Vasaikar S, Zhang B, Hilsenbeck SG, Li W, Foulds CE, Ellis MJ, Chang EC. " Neurofibromin Is an Estrogen Receptor-alpha Transcriptional Co-repressor in Breast Cancer " Cancer Cell. 2020 ; 37 : 387-402.
  Pubmed PMID: 32142667.
• Zheng Z-Y, Chen A, Jaehnig EJ, Anurag M, Lei JT, Feng L, Wang C, Fandino D, Singh P, Kennedy H, Yadav G, Vollert CT, Tsai J, Chen X, Li Y, Lim B, Thompson A, Li S, Foulds CE, Zhang B, Ellis MJ, Chang EC:. " NF1-depleted ER+ breast cancers are differentially sensitive to CDK4/6 inhibitors.. " Sci. Transl. Med.. 2025 Aug 27; 17 : eadq5492.

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Languages

Chinese (Mandarin)