Maria Elena Bottazzi, Ph.D.
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Maria Elena Bottazzi, Ph.D.
Sr. Associate Dean, National School of Tropical Medicine
Phone
Phone
Positions
- Sr. Associate Dean, National School of Tropical Medicine
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Baylor College of Medicine
Houston, Texas United States
- Professor
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Departments of Pediatrics (Tropical Medicine) and Molecular Virology and Microbiology, Integrative Molecular and Biomedical Sciences Program, and Translational Biology and Molecular Medicine Program
Baylor College of Medicine
Houston, Texas United States
- Co-Director
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Texas Children's Hospital Center for Vaccine Development
Houston, Texas United States
- Distinguished Professor of Biology
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Baylor University
- Adjunct Professor
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Department of Bioengineering
Rice University
- Editor-in-Chief
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Current Tropical Medicine Reports
Springer US
Education
- PhD from University Of Florida
- 05/1995 - Gainesville, Florida United States
- Licenciatura en Microbiología y from Universidad Nacional Autónoma de Honduras
- 05/1989 - Tegucigalpa, Departamento Francisco Morazán Honduras
- Post-Doctoral Fellowship at University Of Pennsylvania
- 05/2001 - Philadelphia, PA United States
- Post-Doctoral Fellowship at University Of Miami Hospital And Clinics
- 05/1998 - Miami, FL United States
- Fellowship at American Association for the Advancement of Science Leshner Leadership Institute
- 02/2017 - Washington, DC
Websites
Selected Publications
- Nyon MP, Du L, Tseng CK, Seid CA, Pollet J, Naceanceno KS, Agrawal A, Algaissi A, Peng BH, Tai W, Jiang S, Bottazzi ME, Strych U, Hotez PJ "Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen." Vaccine. 2018; Pubmed PMID: 29496347
- Diemert D, Campbell D, Brelsford J, Leasure C, Li G, Peng J, Zumer M, Younes N, Bottazzi ME, Mejia R, Pritchard DI, Hawdon JM, Bethony JM "Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development." Open Forum Infect Dis. 2018; Pubmed PMID: 29780848
- Villanueva-Lizama LE, Cruz-Chan JV, Aguilar-Cetina ADC, Herrera-Sanchez LF, Rodriguez-Perez JM, Rosado-Vallado ME, Ramirez-Sierra MJ, Ortega-Lopez J, Jones K, Hotez P, Bottazzi ME, Dumonteil E. "Trypanosoma cruzi vaccine candidate antigens Tc24 and TSA-1 recall memory immune response associated with HLA-A and -B supertypes in Chagasic chronic patients from Mexico." PLoS negl trop dis. 2018; Pubmed PMID: 29377898
- Bottazzi ME "The human hookworm vaccine: recent updates and prospects for success.." J Helminthol. 2015; Pubmed PMID: 25850789
- McKenna ML, McAtee S, Bryan PE, Jeun R, Ward T, Kraus J, Bottazzi ME, Hotez PJ, Flowers CC, Mejia R "Human Intestinal Parasite Burden and Poor Sanitation in Rural Alabama." Am J Trop Med Hyg. 2017; Pubmed PMID: 29016326
- Chen WH, Chag SM, Poongavanam MV, Biter AB, Ewere EA, Rezende W, Seid CA, Hudspeth EM, Pollet J, McAtee CP, Strych U, Bottazzi ME, Hotez PJ "Optimization of the Production Process and Characterization of the Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1), a SARS Vaccine Candidate." J Pharm Sci. 2017; Pubmed PMID: 28456726
- Lustigman S, Makepeace BL, Klei TR, Babayan SA, Hotez P, Abraham D, Bottazzi ME "Onchocerca volvulus: The Road from Basic Biology to a Vaccine." Trends in Parasit. 2018; Pubmed PMID: 28958602
- Jiang D, Zhan B, Mayor RS, Gillespie P, Keegan B, Bottazzi ME, Hotez P "Ac-AP-12, a novel factor Xa anticoagulant peptide from the esophageal glands of adult Ancylostoma caninum.." Mol. Biochem. Parasitol.. 2011 May;177(1):42-8. Pubmed PMID: 21251931
- Dumonteil E, Bottazzi ME, Zhan B, Heffernan MJ, Jones K, Valenzuela JG, Kamhawi S, Ortega J, Rosales SP, Lee BY, Bacon KM, Fleischer B, Slingsby B, Cravioto MB, Tapia-Conyer R, Hotez PJ "Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects.." Expert Rev Vaccines. 2012 Sep;11(9):1043-55. Pubmed PMID: 23151163
- Plieskatt JL, Rezende WC, Olsen CM, Trefethen JM, Joshi SB, Middaugh CR, Hotez PJ, Bottazzi ME "Advances in vaccines against neglected tropical diseases: enhancing physical stability of a recombinant hookworm vaccine through biophysical and formulation studies.." Hum Vaccin Immunother. 2012 Jun;8(6):765-76. Pubmed PMID: 22495115
- Roovers K, Davey G, Zhu X, Bottazzi ME, Assoian RK "Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells.." Mol. Biol. Cell. 1999 Oct;10(10):3197-204. Pubmed PMID: 10512860
- Pearson MS, Bethony JM, Pickering DA, de Oliveira LM, Jariwala A, Santiago H, Miles AP, Zhan B, Jiang D, Ranjit N, Mulvenna J, Tribolet L, Plieskatt J, Smith T, Bottazzi ME, Jones K, Keegan B, Hotez PJ, Loukas A "An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection.." FASEB J.. 2009 Sep;23(9):3007-19. Pubmed PMID: 19380510
- Bottazzi ME, Miles AP, Diemert D, Hotez PJ "An ounce of prevention on a budget: a nonprofit approach to developing vaccines against neglected diseases.." Expert Rev Vaccines. 2006 Apr;5(2):189-98. Pubmed PMID: 16608419
- Williamson AL, Lustigman S, Oksov Y, Deumic V, Plieskatt J, Mendez S, Zhan B, Bottazzi ME, Hotez PJ, Loukas A "Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration.." Infect. Immun.. 2006 Feb;74(2):961-7. Pubmed PMID: 16428741
- Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Plieskatt J, Goud G, Bottazzi ME, Zhan B, Wang Y, Williamson A, Lustigman S, Correa-Oliveira R, Xiao S, Hotez PJ "Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals.." FASEB J.. 2005 Oct;19(12):1743-5. Pubmed PMID: 16037096
- Cai S, He F, Samra HS, de la Maza LM, Bottazzi ME, Joshi SB, Middaugh CR "Biophysical and stabilization studies of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein.." Mol. Pharm..;6(5):1553-61. Pubmed PMID: 19650664
- Bottazzi ME, Goodenow MM, Moscovici MG, Moscovici C "BM2L is a spontaneous leukemogenic variant of a non-leukemogenic v-myb-transformed myeloid cell line.." Oncogene. 1993 Mar;8(3):731-6. Pubmed PMID: 8437856
- Hotez PJ, Dumonteil E, Woc-Colburn L, Serpa JA, Bezek S, Edwards MS, Hallmark CJ, Musselwhite LW, Flink BJ, Bottazzi ME "Chagas Disease: The New HIV/AIDS of the Americas"."." PLoS Negl Trop Dis. 2012 May;6(5):e1498. Pubmed PMID: 22666504
- Bottazzi ME, Buzzai M, Zhu X, Desdouets C, Bréchot C, Assoian RK "Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity.." Mol. Cell. Biol.. 2001 Nov;21(22):7607-16. Pubmed PMID: 11604497
- Ambrose MR, Bottazzi ME, Goodenow MM "Expression of the c-ski proto-oncogene during cell cycle arrest and myogenic differentiation.." DNA Cell Biol.. 1995 Aug;14(8):701-7. Pubmed PMID: 7646817
- Goud GN, Bottazzi ME, Zhan B, Mendez S, Deumic V, Plieskatt J, Liu S, Wang Y, Bueno L, Fujiwara R, Samuel A, Ahn SY, Solanki M, Asojo OA, Wang J, Bethony JM, Loukas A, Roy M, Hotez PJ "Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials.." Vaccine. 2005 Sep 15;23(39):4754-64. Pubmed PMID: 16054275
- Mathias DK, Plieskatt JL, Armistead JS, Bethony JM, Abdul-Majid KB, McMillan A, Angov E, Aryee MJ, Zhan B, Gillespie P, Keegan B, Jariwala AR, Rezende W, Bottazzi ME, Scorpio DG, Hotez PJ, Dinglasan RR "Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine.." Infect. Immun.. 2012 Apr;80(4):1606-14. Pubmed PMID: 22311924
- Goud GN, Deumic V, Gupta R, Brelsford J, Zhan B, Gillespie P, Plieskatt JL, Tsao EI, Hotez PJ, Bottazzi ME "Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): A production process developed for a lead candidate recombinant hookworm vaccine antigen.." Protein Expr. Purif.. 2012 Jun;83(2):145-51. Pubmed PMID: 22503665
- Bonafé N, Zhan B, Bottazzi ME, Perez OA, Koski RA, Asojo OA "Expression, purification, crystallization and preliminary X-ray analysis of a truncated soluble domain of human glioma pathogenesis-related protein 1.." Acta Crystallogr. Sect. F Struct. Biol. Cryst. 2010 Nov 1;66:1487-9. Pubmed PMID: 21045302
- Kehn K, Berro R, Alhaj A, Bottazzi ME, Yeh WI, Klase Z, Van Duyne R, Fu S, Kashanchi F "Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells.." Oncogene. 2007 Aug 2;26(35):5060-9. Pubmed PMID: 17334399
- Zhan B, Santiago H, Keegan B, Gillespie P, Xue J, Bethony J, de Oliveira LM, Jiang D, Diemert D, Xiao SH, Jones K, Feng X, Hotez PJ, Bottazzi ME "Fusion of Na-ASP-2 with human immunoglobulin Fc? abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE.." Parasite Immunol.. 2012 Aug;34(41495):404-11. Pubmed PMID: 22651670
- Lee BY, Bacon KM, Bottazzi ME, Hotez PJ "Global economic burden of Chagas disease: a computational simulation model.." Lancet Infect Dis. 2013 Apr;13(4):342-8. Pubmed PMID: 23395248
- Hotez PJ, Arora S, Bethony J, Bottazzi ME, Loukas A, Correa-Oliveira R, Brooker S "Helminth infections of children: prospects for control.." Adv. Exp. Med. Biol.. 2005;568:135-44. Pubmed PMID: 16108129
- Hotez PJ, Brooker S, Bethony JM, Bottazzi ME, Loukas A, Xiao S "Hookworm infection.." N. Engl. J. Med.. 2004 Aug 19;351(8):799-807. Pubmed PMID: 15317893
- Hotez PJ, Bethony J, Bottazzi ME, Brooker S, Buss P "Hookworm: the great infection of mankind"."." PLoS Med.. 2005 Mar;2(3):e67. Pubmed PMID: 15783256
- Fujiwara RT, Bethony J, Bueno LL, Wang Y, Ahn SY, Samuel A, Bottazzi ME, Hotez P, Mendez S "Immunogenicity of the hookworm Na-ASP-2 vaccine candidate: characterization of humoral and cellular responses after vaccination in the Sprague Dawley rat.." ;1(3):123-8. Pubmed PMID: 17012856
- Hotez PJ, Dumonteil E, Heffernan MJ, Bottazzi ME "Innovation for the 'bottom 100 million': eliminating neglected tropical diseases in the Americas.." Adv. Exp. Med. Biol.. 2013;764:41286. Pubmed PMID: 23654053
- Bottazzi ME, Brown AS "Model for product development of vaccines against neglected tropical diseases: a vaccine against human hookworm.." Expert Rev Vaccines. 2008 Dec;7(10):1481-92. Pubmed PMID: 19053205
- Lee BY, Bacon KM, Wateska AR, Bottazzi ME, Dumonteil E, Hotez PJ "Modeling the economic value of a Chagas' disease therapeutic vaccine.." Hum Vaccin Immunother. 2012 Sep 1;8(9):1293-301. Pubmed PMID: 22894964
- Zhan B, Perally S, Brophy PM, Xue J, Goud G, Liu S, Deumic V, de Oliveira LM, Bethony J, Bottazzi ME, Jiang D, Gillespie P, Xiao SH, Gupta R, Loukas A, Ranjit N, Lustigman S, Oksov Y, Hotez P "Molecular Cloning, Biochemical Characterization, and Partial Protective Immunity of the Heme-Binding Glutathione S-Transferases from the Human Hookworm Necator americanus.." Infect. Immun.. 2010 Apr;78(4):1552-63. Pubmed PMID: 20145100
- Hotez PJ, Bethony J, Bottazzi ME, Brooker S, Diemert D, Loukas A "New technologies for the control of human hookworm infection.." Trends Parasitol.. 2006 Jul;22(7):327-31. Pubmed PMID: 16709466
- Jariwala AR, Oliveira LM, Diemert DJ, Keegan B, Plieskatt JL, Periago MV, Bottazzi ME, Hotez PJ, Bethony JM "Potency testing for the experimental Na-GST-1 hookworm vaccine.." Expert Rev Vaccines. 2010 Oct;9(10):1219-30. Pubmed PMID: 20923271
- Hotez PJ, Zhan B, Bethony JM, Loukas A, Williamson A, Goud GN, Hawdon JM, Dobardzic A, Dobardzic R, Ghosh K, Bottazzi ME, Mendez S, Zook B, Wang Y, Liu S, Essiet-Gibson I, Chung-Debose S, Xiao S, Knox D, Meagher M, Inan M, Correa-Oliveira R, Vilk P, Sheph "Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative.." Int. J. Parasitol.. 2003 Sep 30;33(11):1245-58. Pubmed PMID: 13678639
- Fujiwara RT, Zhan B, Mendez S, Loukas A, Bueno LL, Wang Y, Plieskatt J, Oksov Y, Lustigman S, Bottazzi ME, Hotez P, Bethony JM "Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16.." Clin. Vaccine Immunol.. 2007 Mar;14(3):281-7. Pubmed PMID: 17267592
- Jiang S, Bottazzi ME, Du L, Lustigman S, Tseng CT, Curti E, Jones K, Zhan B, Hotez PJ "Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome.." Expert Rev Vaccines. 2012 Dec;11(12):1405-13. Pubmed PMID: 23252385
- Hotez PJ, Bottazzi ME, Dumonteil E, Valenzuela JG, Kamhawi S, Ortega J, Ponce de Leon Rosales S, Betancourt Cravioto M, Tapia-Conyer R "Texas and Mexico: sharing a legacy of poverty and neglected tropical diseases.." PLoS Negl Trop Dis. 2012 Mar;6(3):e1497. Pubmed PMID: 22479656
- Hotez PJ, Diemert D, Bacon KM, Beaumier C, Bethony JM, Bottazzi ME, Brooker S, Couto AR, Freire Mda S, Homma A, Lee BY, Loukas A, Loblack M, Morel CM, Oliveira RC, Russell PK "The Human Hookworm Vaccine.." Vaccine. 2013 Apr 18;31:B227-32. Pubmed PMID: 23598487
- Hotez PJ, Bottazzi ME, Franco-Paredes C, Ault SK, Periago MR "The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination.." PLoS Negl Trop Dis. 2008;2(9):e300. Pubmed PMID: 18820747
- Bacon KM, Hotez PJ, Kruchten SD, Kamhawi S, Bottazzi ME, Valenzuela JG, Lee BY "The potential economic value of a cutaneous leishmaniasis vaccine in seven endemic countries in the Americas.." Vaccine. 2013 Jan 7;31(3):480-6. Pubmed PMID: 23176979
- Kehn K, Deng L, de la Fuente C, Strouss K, Wu K, Maddukuri A, Baylor S, Rufner R, Pumfery A, Bottazzi ME, Kashanchi F "The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells.." Retrovirology. 2004;1:6. Pubmed PMID: 15169570
- Franco-Paredes C, Bottazzi ME, Hotez PJ "The unfinished public health agenda of chagas disease in the era of globalization.." PLoS Negl Trop Dis. 2009;3(7):e470. Pubmed PMID: 19582139
- Fujiwara RT, Loukas A, Mendez S, Williamson AL, Bueno LL, Wang Y, Samuel A, Zhan B, Bottazzi ME, Hotez PJ, Bethony JM "Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs.." Vaccine. 2006 Jan 23;24(4):501-9. Pubmed PMID: 16140437
- Loukas A, Bethony JM, Mendez S, Fujiwara RT, Goud GN, Ranjit N, Zhan B, Jones K, Bottazzi ME, Hotez PJ "Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs.." PLoS Med.. 2005 Oct;2(10):e295. Pubmed PMID: 16231975
- Ghosh K, Wu W, Antoine AD, Bottazzi ME, Valenzuela JG, Hotez PJ, Mendez S "The impact of concurrent and treated Ancylostoma ceylanicum hookworm infections on the immunogenicity of a recombinant hookworm vaccine in hamsters.." J. Infect. Dis.. 2006 Jan 1;193(1):155-62. Pubmed PMID: 16323144
- Kehn K, Fuente Cde L, Strouss K, Berro R, Jiang H, Brady J, Mahieux R, Pumfery A, Bottazzi ME, Kashanchi F "The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation.." Oncogene. 2005 Jan 20;24(4):525-40. Pubmed PMID: 15580311
- Bottazzi ME, Assoian RK "The extracellular matrix and mitogenic growth factors control G1 phase cyclins and cyclin-dependent kinase inhibitors.." Trends Cell Biol.. 1997 Sep;7(9):348-52. Pubmed PMID: 17708979
- Seelamgari A, Maddukuri A, Berro R, de la Fuente C, Kehn K, Deng L, Dadgar S, Bottazzi ME, Ghedin E, Pumfery A, Kashanchi F "Role of viral regulatory and accessory proteins in HIV-1 replication.." Front. Biosci.. 2004 Sep 1;9:2388-413. Pubmed PMID: 15353294
- Bottazzi ME, Zhu X, Böhmer RM, Assoian RK "Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase.." J. Cell Biol.. 1999 Sep 20;146(6):1255-64. Pubmed PMID: 10491389
- Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F "Protein profile of tax-associated complexes.." J. Biol. Chem.. 2004 Jan 2;279(1):495-508. Pubmed PMID: 14530271
- Kehn K, Berro R, de la Fuente C, Strouss K, Ghedin E, Dadgar S, Bottazzi ME, Pumfery A, Kashanchi F "Mechanisms of HTLV-1 transformation.." Front. Biosci.. 2004 Sep 1;9:2347-72. Pubmed PMID: 15353292
- Campi-Azevedo AC, Gazzinelli G, Bottazzi ME, Teixeira-Carvalho A, Corrêa-Oliveira R, Caldas IR "In vitro cultured peripheral blood mononuclear cells from patients with chronic schistosomiasis mansoni show immunomodulation of cyclin D1,2,3 in the presence of soluble egg antigens.." Microbes Infect.. 2007 Oct;9(41621):1493-9. Pubmed PMID: 17913547
- Gunter SM, Jones KM, Seid CA, Essigmann HT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Brown EL "Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy. Infection and immunity." J Parasit. 2017; Pubmed PMID: 28581897
Projects
- Coronavirus vaccines
- New vaccines against coronaviruses including Covid-19
- Chagas Disease and Leishmaniasis Vaccine
- Development for a new therapeutic vaccine for Chagas disease. Current efforts focus on the development of two vaccine candidate antigens that will ultimately comprise the first therapeutic vaccine for Chagas disease.
- Human Hookworm Vaccine
- Development of a vaccine for the more than 700 million people suffering from hookworm in the world today. Vaccine currently in phase 1 clinical trials.
- Schistosomiasis Vaccine
- Schistosomiasis afflicts over 200 million people around the globe and is the deadliest disease among the seven most prevalent NTDs, killing an estimated 280,000 people annually.
- Multivalent Anthelmintic Vaccine Discovery
- A panhelmintic vaccine to prevent ascariasis (roundworm) and trichuris (whipworm), soil-transmitted helminths afflicting hundreds of millions of people around the world.
- Development of a novel adjuvant for vaccine sparing
- To develop a highly effective and safe protein adjuvant in a simple aqueous formulation that requires a much lower dose of antigen and that can be administered to humans to boost their immune response.
Memberships
- American Society of Tropical Medicine and Hygiene
- Member
- American Society for Microbiology
Languages
Italian, Spanish, Portuguese
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