Ayse Leyla Mindikoglu, M.D., M.P.H.
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Positions
- Professor of Medicine
-
Margaret M. and Albert B. Alkek Department of Medicine, Section of Gastroenterology and Hepatology
Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation
Baylor College of Medicine
Addresses
- Baylor Clinic (Clinic)
-
6620 Main Street
Suite 1450
Houston, TX 77030
United States
SCHEDULE APPOINTMENT - (832) 355-1400
Education
- Fellowship at University of Miami Leonard M. Miller School of Medicine
- 06/2005 - Miami, Florida United States
- Advanced Hepatology
- Fellowship at Loyola University Medical Center
- 06/2004 - Maywood, Illinois United States
- Gastroenterology and Hepatology
- Residency at Bronx-Lebanon Hospital Center
- 06/2001 - Bronx, New York United States
- Internal Medicine
- Residency at University of Istanbul, Cerrahpasa Faculty of Medicine
- Istanbul, Turkey
- General Surgery (1995-1998)
- MD from University of Istanbul, Cerrahpasa Faculty of Medicine
- 07/1995 - Istanbul, Turkey
- MPH from University of Maryland Baltimore
- 12/2007 - Baltimore, Maryland United States
- Master of Public Health, Epidemiology and Biostatistics Track
Certifications
- Internal Medicine
- American Board of Internal Medicine
- Gastroenterology
- American Board of Internal Medicine
- Transplant Hepatology
- American Board of Internal Medicine
Honors & Awards
- 2023 US National Academy of Medicine Healthy Longevity Global Competition Catalyst Award for the project entitled, "Dawn-to-Dusk Dry Fasting for Rapid Reversal of Aging"
- 2023 Norton Rose Fulbright Faculty Excellence Award in Teaching and Evaluation
- 2023 Star Faculty Award for Excellence in Patient Care
- 2022 Women of Excellence Award
- 2021 Roderick D. MacDonald Research Award/Baylor St. Luke’s Medical Center
- 2020 Roderick D. MacDonald Research Award/Baylor St. Luke’s Medical Center
- 2019 Roderick D. MacDonald Research Award/Baylor St. Luke’s Medical Center
- 2017 Roderick D. MacDonald Research Award/Baylor St. Luke’s Medical Center
- 2019 Fellow, American Association for the Study of Liver Diseases
- In 2019, Dr. Mindikoglu was awarded The Fellow of the American Association for the Study of Liver Diseases (FAASLD) that epitomizes excellence and contributions to AASLD and to the field of liver disease.
- 2017 Faculty Research Award, Baylor College of Medicine, Michael E. DeBakey Department of Surgery (Dr. Mindikoglu declined this award due to an another successful overlapping award)
- 2017 Poster of Distinction at Digestive Disease Week®, Chicago, IL
- 2011 Presidential Poster of Distinction at the Liver Meeting 2011 of the American Association of the Study for Liver Diseases (AASLD), San Francisco, CA
- 2010 Mentored Patient-Oriented Research Career Development Award (National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases K23)
- 2004 American Association for the Study of Liver Diseases Advanced Hepatology Fellowship Award
- 2002 Travel Grant for the 8th Methodologies in Healthcare Outcomes in Gastroenterology Workshop Symposium sponsored by Gastroenterology Research Group (GRG) and the American Gastroenterological Association (AGA)
- 2002 Third Place Abstract Presentation in Annual Research Prize Competition of the Chicago Society for Gastroenterology
- 2002 Winner of the Biannual Chicago Academic Debate entitled “Liver Disease: Controversies in the New Millennium”
Professional Interests
- Cirrhosis and complications (Ascites, esophageal/gastric varices, gastric antral vascular ectasia, portal hypertensive gastropathy, encephalopathy, hepatocellular carcinoma, hepatorenal syndrome, portopulmonary syndrome, hepatopulmonary syndrome)
- Chronic liver diseases (e.g. Fatty liver, hepatitis B, hepatitis C, autoimmune hepatitis, alcoholic hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, Wilson disease, hemochromatosis, drug-induced liver injury)
- Acute liver failure
- Benign and malignant liver tumors
- Liver transplantation (Evaluation for liver transplantation and simultaneous liver- kidney, liver-heart, liver-lung and liver-multiorgan transplantation)
- Post-liver transplant management (Acute and chronic liver graft rejection, immunosuppressive medication management, treatment of post-liver transplant recurrent hepatitis and liver disease)
- Endoscopy (Esophagogastroduodenoscopy, variceal banding, colonoscopy)
- Intermittent fasting
- Fatty liver disease
Professional Statement
Dr. Ayse Leyla Mindikoglu is board-certified in Internal Medicine, Gastroenterology, and Transplant Hepatology with more than 18 years of experience in academic clinical practice. She is a clinician, researcher, and educator.Dr. Mindikoglu's current research studies investigate the effect of dawn-to-dusk dry fasting on human metabolism, proteome and aging.
Dr. Mindikoglu's previous research studies were focused on renal dysfunction and acute kidney injury in cirrhosis and the development of new biomarkers of glomerular filtration rate in cirrhosis. Supported by the NIH/NIDDK K23 award between 2010 and 2015 and Roderick D. MacDonald Research Award/Baylor St. Luke's Medical Center between 2017, Dr. Mindikoglu conducted several clinical studies to understand critical concepts of altered renal hemodynamics in cirrhosis and develop metabolomic biomarkers of cirrhosis.
Websites
Dawn-to-sunset fasting could help those suffering from metabolic syndrome
Dawn-to-sunset fasting associated with anti-cancer proteins
How fasting may prevent obesity-related insulin resistance - Medical News Today
Dawn-to-sunset fasting suggests potential new treatment for obesity-related conditions
Dawn-to-sunset fasting suggests potential new treatment for obesity-related conditions
Study of 30-day Ramadan fast shows promising implications for timing and duration between meals
Selected Publications
- Mindikoglu AL, Park J, Opekun AR, Abdulsada MM, Wilhelm ZR, Jalal PK, Devaraj S, Jung SY "Dawn-to-dusk dry fasting induces anti-atherosclerotic, anti-inflammatory, and anti-tumorigenic proteome in peripheral blood mononuclear cells in subjects with metabolic syndrome." 2022;16
- Bhatti SI, Mindikoglu AL. "The impact of dawn to sunset fasting on immune system and its clinical significance in Covid-19 pandemic." Metabol Open. 2021; Pubmed PMID: 34977523
- Mindikoglu AL, Abdulsada MM, Jain A, Jalal PK, Devaraj S, Wilhelm ZR, Opekun AR, Jung SY. "Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome.." Sci Rep. 2020; Pubmed PMID: 33110154
- Mindikoglu AL, Abdulsada MM, Jain A, et al. "Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling,...." J Proteomics. 2020; Pubmed PMID: 31927066
- Al Lami Z, Kurtca M, Atique MU, Opekun AR, Siam MS, Jalal PK, Najafi B, Devaraj S, Mindikoglu AL "Dawn-to-dusk dry fasting decreases circulating inflammatory cytokines in subjects with increased body mass index." Metabol Open. 2024 Mar;21 Pubmed PMID: 38455231
- Mindikoglu AL, Opekun AR, Sood G, Devaraj S "Impact of Time-Restricted Feeding and Dawn to Sunset Fasting on Circadian Rhythm, Obesity, Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease." Gastroenterol Res Pract. 2017; Pubmed PMID: 29348746
- Mindikoglu AL, Opekun AR, Putluri N, Devaraj S, Sheikh-Hamad D, Vierling JM, Goss J, Rana A, Sood G, Jalal P, Inker LA, Mohney RP, Tighiouart H, Christenson RH, Dowling TC, Weir MR, Seliger SL, Hutson WR, Howell C, Raufman JP, Magder LS, Coarfa C "Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis." Transl Res.; Pubmed PMID: 29291380
- Mindikoglu AL, Pappas SC "New Developments in Hepatorenal Syndrome." Clin Gastroenterol Hepatol.; Pubmed PMID: 28602971
- Mindikoglu AL, Opekun AR, Mitch WE, Magder LS, Christenson RH, Dowling TC, Weir MR, Seliger SL, Howell CD, Raufman JP, Rana A, Goss JA, Khaderi SA, Vierling JM. "Cystatin C Is a Gender-Neutral Glomerular Filtration Rate Biomarker in Patients with Cirrhosis." Dig Dis Sci. 2018;63:665-75.
- Mindikoglu AL, Dowling TC, Magder LS, Christenson RH, Weir MR, Seliger SL, Hutson WR, Howell CD "Estimation of glomerular filtration rate in patients with cirrhosis by use of new and conventional filtration markers and dimethylarginines." Clin Gastroenterol Hepatol. 2016;14:624-32.
- Mindikoglu AL, Regev A, Seliger SL, Magder LS "Gender disparity in liver transplant waiting list mortality: The Importance of kidney function." Liver Transplant. 2010;16:1147-57.
- Mindikoglu AL, Dowling TC, Wong-You-Cheong JJ, Christenson RH, Magder LS, Hutson WR, Seliger SL, Weir MR "A Pilot Study to Evaluate Renal Hemodynamics in Cirrhosis by Simultaneous Glomerular Filtration Rate, Renal Plasma Flow, Renal Resistive Indices and Biomarkers Measurements." Am J Nephrol. 2014;39:543-552.
- Mindikoglu AL, Dowling TC, Weir MR, Seliger SL, Christenson RH, Magder LS "Performance of Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation for estimating kidney function in cirrhosis." Hepatology. 2014;59:1532-42.
- Mindikoglu AL, Dowling TC, Schaub DJ, Hutson WR, Potosky DR, Christenson RH, Barth RN, LaMattina JC, Hanish SI, Weir MR, Raufman JP "Pharmacokinetics and tolerability of intravenous sildenafil in two subjects with Child-Turcotte-Pugh class C cirrhosis and renal dysfunction." Dig Dis Sci. 2016;60:3491-4.
- Mindikoglu AL, Magder LS, Regev A. Outcome of liver transplantation for drug-induced acute liver failure in the United States. Analysis of the United Network for Organ Sharing Database "Outcome of liver transplantation for drug-induced acute liver failure in the United States. Analysis of the United Network for Organ Sharing Database." Liver Transplant. 2009;15:719-29.
- Magder LS, Regev A, Mindikoglu AL "Comparison of Seven Liver Allocation Models with Respect to Lives Saved Among Patients on the Liver Transplant Waiting List." Transpl Int. 2012;25:409-15.
- Urrunaga N, Magder LS, Weir MR, Rockey DC, Mindikoglu AL "Prevalence, Severity and Impact of Renal Dysfunction in Acute Liver Failure on the U.S. Liver Transplant Waiting List." Dig Dis Sci. 2016;61:309-16.
- Mindikoglu AL, King D, Magder LS, Ozolek JA, Mazariegos GV, Shneider BL "Valproic acid-associated acute liver failure in children: case report and analysis of liver transplantation outcomes in the United States." J Pediatr. 2011;158:802-7.
- Mindikoglu AL, Raufman JP, Seliger SL, Howell CD, Magder LS "Simultaneous liver-kidney versus liver transplantation alone in patients with end-stage liver disease and kidney dysfunction not on dialysis." Transplant Proc. 2011;43:2669-77.
Memberships
- The American Association for the Study of Liver Diseases (AASLD)
- Fellow
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