- Associate Professor of Medicine
Margaret M. and Albert B. Alkek Department of Medicine, Section of Gastroenterology and Hepatology
Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation
Baylor College of Medicine
- Baylor Clinic (Clinic)
6620 Main Street
Houston, TX 77030
SCHEDULE APPOINTMENT - (832) 355-1400
- Fellowship at University of Miami Leonard M. Miller School of Medicine
- 06/2005 - Miami, Florida United States
- Advanced Hepatology
- Fellowship at Loyola University Medical Center
- 06/2004 - Maywood, Illinois United States
- Gastroenterology and Hepatology
- Residency at Bronx-Lebanon Hospital Center
- 06/2001 - Bronx, New York United States
- Internal Medicine
- Residency at University of Istanbul, Cerrahpasa Faculty of Medicine
- Istanbul, Turkey
- General Surgery (1995-1998)
- MD from University of Istanbul, Cerrahpasa Faculty of Medicine
- 07/1995 - Istanbul, Turkey
- MPH from University of Maryland Baltimore
- 12/2007 - Baltimore, Maryland United States
- Master of Public Health, Epidemiology and Biostatistics Track
- Internal Medicine
- American Board of Internal Medicine
- American Board of Internal Medicine
- Transplant Hepatology
- American Board of Internal Medicine
Honors & Awards
- 2010 Mentored Patient-Oriented Research Career Development Award (National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases K23)
- 2019 Roderick D. MacDonald Research Award/Baylor St. Luke’s Medical Center
- 2017 Roderick D. MacDonald Research Award/Baylor St. Luke’s Medical Center
- 2017 Faculty Research Award, Baylor College of Medicine, Michael E. DeBakey Department of Surgery (Dr. Mindikoglu declined this award due to an another successful overlapping award)
- 2004 American Association for the Study of Liver Diseases Advanced Hepatology Fellowship Award
- 2011 Presidential Poster of Distinction at the Liver Meeting 2011 of the American Association of the Study for Liver Diseases (AASLD), San Francisco, CA
- 2019 Fellow, American Association for the Study of Liver Diseases
- In 2019, Dr. Mindikoglu was awarded The Fellow of the American Association for the Study of Liver Diseases (FAASLD) that epitomizes excellence and contributions to AASLD and to the field of liver disease.
- 2002 Travel Grant for the 8th Methodologies in Healthcare Outcomes in Gastroenterology Workshop Symposium sponsored by Gastroenterology Research Group (GRG) and the American Gastroenterological Association (AGA)
- 2002 Third Place Abstract Presentation in Annual Research Prize Competition of the Chicago Society for Gastroenterology
- 2002 Winner of the Biannual Chicago Academic Debate entitled “Liver Disease: Controversies in the New Millennium”
- 2017 Poster of Distinction at Digestive Disease Week®, Chicago, IL
- 2020 Roderick D. MacDonald Research Award/Baylor St. Luke’s Medical Center
- Cirrhosis and complications (Ascites, esophageal/gastric varices, gastric antral vascular ectasia, portal hypertensive gastropathy, encephalopathy, hepatocellular carcinoma, hepatorenal syndrome, portopulmonary syndrome, hepatopulmonary syndrome)
- Chronic liver diseases (e.g. Fatty liver, hepatitis B, hepatitis C, autoimmune hepatitis, alcoholic hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, Wilson disease, hemochromatosis, drug-induced liver injury)
- Acute liver failure
- Benign and malignant liver tumors
- Liver transplantation (Evaluation for liver transplantation and simultaneous liver- kidney, liver-heart, liver-lung and liver-multiorgan transplantation)
- Post-liver transplant management (Acute and chronic liver graft rejection, immunosuppressive medication management, treatment of post-liver transplant recurrent hepatitis and liver disease)
- Endoscopy (Esophagogastroduodenoscopy, variceal banding, colonoscopy)
Professional StatementDr. Ayse Leyla Mindikoglu is board-certified in Internal Medicine, Gastroenterology and Transplant Hepatology with over 14 years of experience in academic clinical practice.
Dr. Mindikoglu's current research investigates the effect of intermittent fasting from dawn to sunset on human serum proteome and metabolism in healthy subjects and subjects with metabolic syndrome and nonalcoholic fatty liver disease.
Additionally, Dr. Mindikoglu's research has been focused on renal dysfunction and acute kidney injury in cirrhosis, and the development of new biomarkers of glomerular filtration rate in cirrhosis. Supported by the NIH/NIDDK K23 award between 2010 and 2015, and Roderick D. MacDonald Research Award/Baylor St. Luke's Medical Center between 2017 and 2019, Dr. Mindikoglu conducted several clinical studies to understand key concepts of altered renal hemodynamics in cirrhosis and develop metabolomic biomarkers of cirrhosis.
Dawn-to-sunset fasting could help those suffering from metabolic syndrome
Dawn-to-sunset fasting associated with anti-cancer proteins
How fasting may prevent obesity-related insulin resistance - Medical News Today
Dawn-to-sunset fasting suggests potential new treatment for obesity-related conditions
Dawn-to-sunset fasting suggests potential new treatment for obesity-related conditions Study of 30-day Ramadan fast shows promising implications for timing and duration between meals
- Mindikoglu AL, Abdulsada MM, Jain A, Jalal PK, Devaraj S, Wilhelm ZR, Opekun AR, Jung SY. "Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome.." Sci Rep. 2020 :
- Mindikoglu AL, Abdulsada MM, Jain A, et al. "Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling,...." J Proteomics. 2020 : Pubmed PMID: 31927066
- Mindikoglu AL, Opekun AR, Sood G, Devaraj S "Impact of Time-Restricted Feeding and Dawn to Sunset Fasting on Circadian Rhythm, Obesity, Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease." Gastroenterol Res Pract. 2017 :
- Mindikoglu AL, Opekun AR, Putluri N, Devaraj S, Sheikh-Hamad D, Vierling JM, Goss J, Rana A, Sood G, Jalal P, Inker LA, Mohney RP, Tighiouart H, Christenson RH, Dowling TC, Weir MR, Seliger SL, Hutson WR, Howell C, Raufman JP, Magder LS, Coarfa C "Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis." Transl Res. : Pubmed PMID: 29291380
- Mindikoglu AL, Pappas SC "New Developments in Hepatorenal Syndrome." Clin Gastroenterol Hepatol. : Pubmed PMID: 28602971
- Mindikoglu AL, Opekun AR, Mitch WE, Magder LS, Christenson RH, Dowling TC, Weir MR, Seliger SL, Howell CD, Raufman JP, Rana A, Goss JA, Khaderi SA, Vierling JM. "Cystatin C Is a Gender-Neutral Glomerular Filtration Rate Biomarker in Patients with Cirrhosis." Dig Dis Sci. 2018 63 : 665-75.
- Mindikoglu AL, Dowling TC, Magder LS, Christenson RH, Weir MR, Seliger SL, Hutson WR, Howell CD "Estimation of glomerular filtration rate in patients with cirrhosis by use of new and conventional filtration markers and dimethylarginines." Clin Gastroenterol Hepatol. 2016 14 : 624-32.
- Mindikoglu AL, Regev A, Seliger SL, Magder LS "Gender disparity in liver transplant waiting list mortality: The Importance of kidney function." Liver Transplant. 2010 16 : 1147-57.
- Mindikoglu AL, Dowling TC, Wong-You-Cheong JJ, Christenson RH, Magder LS, Hutson WR, Seliger SL, Weir MR "A Pilot Study to Evaluate Renal Hemodynamics in Cirrhosis by Simultaneous Glomerular Filtration Rate, Renal Plasma Flow, Renal Resistive Indices and Biomarkers Measurements." Am J Nephrol. 2014 39 : 543-552.
- Mindikoglu AL, Dowling TC, Weir MR, Seliger SL, Christenson RH, Magder LS "Performance of Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation for estimating kidney function in cirrhosis." Hepatology. 2014 59 : 1532-42.
- Mindikoglu AL, Dowling TC, Schaub DJ, Hutson WR, Potosky DR, Christenson RH, Barth RN, LaMattina JC, Hanish SI, Weir MR, Raufman JP "Pharmacokinetics and tolerability of intravenous sildenafil in two subjects with Child-Turcotte-Pugh class C cirrhosis and renal dysfunction." Dig Dis Sci. 2016 60 : 3491-4.
- Mindikoglu AL, Magder LS, Regev A. Outcome of liver transplantation for drug-induced acute liver failure in the United States. Analysis of the United Network for Organ Sharing Database "Outcome of liver transplantation for drug-induced acute liver failure in the United States. Analysis of the United Network for Organ Sharing Database." Liver Transplant. 2009 15 : 719-29.
- Magder LS, Regev A, Mindikoglu AL "Comparison of Seven Liver Allocation Models with Respect to Lives Saved Among Patients on the Liver Transplant Waiting List." Transpl Int. 2012 25 : 409-15.
- Urrunaga N, Magder LS, Weir MR, Rockey DC, Mindikoglu AL "Prevalence, Severity and Impact of Renal Dysfunction in Acute Liver Failure on the U.S. Liver Transplant Waiting List." Dig Dis Sci. 2016 61 : 309-16.
- Mindikoglu AL, King D, Magder LS, Ozolek JA, Mazariegos GV, Shneider BL "Valproic acid-associated acute liver failure in children: case report and analysis of liver transplantation outcomes in the United States." J Pediatr. 2011 158 : 802-7.
- Mindikoglu AL, Raufman JP, Seliger SL, Howell CD, Magder LS "Simultaneous liver-kidney versus liver transplantation alone in patients with end-stage liver disease and kidney dysfunction not on dialysis." Transplant Proc. 2011 43 : 2669-77.
- The American Association for the Study of Liver Diseases (AASLD)
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