Email

Positions

Instructor

Medicine - Epidemiology & Population Science
Baylor College of Medicine

Education

Postdoctoral Fellowship at University of Toronto

10/2025 - Toronto

Websites

Selected Publications

• Yue Xu*; Haotian Cui*; Kuan Pang; Gen Li; Fanglin Gong; Songtao Dong; Bo Wang; Bowen Li. " LUMI-lab: a Foundation Model-Driven Autonomous Platform Enabling Discovery of New Ionizable Lipid Designs for mRNA Delivery " Cell. 2026 Mar 17;
  Pubmed PMID: 41742414.
• Yue Xu*, Fanglin Gong*, Alex Golubovic*, Amy Strilchuk, Jingan Chen, Muye Zhou, Songtao Dong, Breanna Seto, and Bowen Li. " Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery " PNAS. 2025 Feb 4;
  Pubmed PMID: 39883839.
• Yue Xu*, Shihao Ma*, Haotian Cui*, Jingan Chen, Shufen Xu, Fanglin Gong, Alex Golubovic, Muye Zhou, Kevin Chang Wang, Andrew Varley, and others. " AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery " Nat. Commun.. 2024 Jul 26;
  Pubmed PMID: 39060305.
• Fanglin Gong*，Yue Xu*, Jingan Chen. et al.. " Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung " Nat. Mater.. 2026 Apr 1;
  Pubmed PMID: 41922838.
• Shufen Xu*, Yue Xu*, Nicholas C Solek, Jingan Chen, Fanglin Gong, Andrew James Varley, Alex Golubovic, Anni Pan, Songtao Dong, Gang Zheng, and Bowen Li. " Tumor-tailored ionizable lipid nanoparticles facilitate IL-12 circular RNA delivery for enhanced lung cancer immunotherapy " Adv. Mater.. 2024 Apr 24;
  Pubmed PMID: 38657273.
• Jingan Chen*, Yue Xu*, Muye Zhou, Shufen Xu, Andrew James Varley, Alex Golubovic, Rick Xing Ze Lu, Kevin Chang Wang, Mina Yeganeh, Daniel Vosoughi, and Bowen Li. " Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects " PNAS. 2023 Dec 7;
  Pubmed PMID: 38060560.
• Muye Zhou*; Yue Xu*; Gen Li*; et al. " A multi-objective AI model for LNP Engineering enhances tissue-selective mRNA delivery,. " Nat. Biotech.. 2026 ;
• Songtao Dong*, Shannon Tsai*, Yue Xu, Fanglin Gong, Tiana Young, Nicholas Solek, Daniel Chen, Liam Healy*, Myroslav Savguira, Muye Zhou, Jingan Chen, Alex Golubovic, Rick Lu, Tian He, Haoyuan He, and Bowen Li. " A modular mRNA platform for programmable induction of tumour-specific immunogenic cell death " Nat. Nanotechnol.. 2025 Dec 20;
  Pubmed PMID: 41162605.