Yaping Pan, Ph.D.

Assistant Professor

Email

Yaping.Pan@bcm.edu

Positions

Assistant Professor: Biochemistry-M Zhou Lab
Baylor College of Medicine
Houston, TX, US

Addresses

Baylor College of Medicine (Office): BCM-Smith Medical Research Bldg
Room: BCMS-334
Houston, TX, 77030
United States
Phone: (713) 798-3938
Yaping.Pan@bcm.edu

Education

BS from Fudan University: 06/1999 - Shanghai, China; Pharmacology

PhD from Peking Union Medical College: 06/2004 - Beijing, China; Pharmacology

Post-Doctoral Fellowship at Baylor College of Medicine: 09/2005 - Houston, Texas, United States; Neuroscience

Post-Doctoral Fellowship at Columbia University: 04/2011 - New York, New York, United States; Physiology

Professional Statement

My research focuses on understanding structure, function and modulation of ion channels and transporters.

Websites

VIICTR Profile

Selected Publications

Cao Y*, Pan Y*, Huang H*, Jin X, Levin EJ, Kloss B, Zhou M.. " Gating of the TrkH ion channel by its associated RCK protein TrkA " Nature. 2013 Apr 18; 496 (7445) : 317-322.
Pubmed PMID: 3726529.
Pan Y, Levin EJ, Quick M, Zhou M.. " Potentiation of the Kv1 family K+ channel by cortisone analogues " ACS Chemical Biology. 2012 Oct 19; 7 (10) : 1641-1646.
Pubmed PMID: 3567311.
Pan Y, Weng J, Levin EJ, Zhou M.. " Oxidation of NADPH inhibits ball-and-chain type inactivation by restraining the chain " Proceedings of the National Academy of Scienc. 2011 Apr 5; 108 (14) : 5885-90.
Pubmed PMID: 3078402.
Pan Y, Weng J, Kabaleeswaran V, Li H, Cao Y, Bhosle R, Zhou M.. " Cortisone dissociates Shaker family K+ channels from their Beta subunits " Nature Chemical Biology. 2008 Nov ; 4 (11) : 708-14.
Pubmed PMID: 2633621.
Pan Y, Weng J, Cao Y, Bhosle R, Zhou M.. " Functional coupling between the Kv1.1 channel and aldoketoreductase Kvbeta1 " Journal of Biological Chemistry. 2008 Mar 28; 283 (13) : 8634-8642.
Pubmed PMID: 2417172.
Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M.. " Structural basis of ion transport and inhibition in ferroportin " Nature Communications. 2020 Nov ; 11 (1) : 5686.
Pubmed PMID: 33173040.
Wilbon AS, Shen J, Ruchala P, Zhou M, Pan Y.. " Structural basis of ferroportin inhibition by minihepcidin PR73 " PLoS Biology. 2023 Jan ; 21 (1) : e3001936.
Pubmed PMID: 36649314.
Shen J, Wilbon AS, Zhou M, Pan Y.. " Mechanism of Ca2+ transport by ferroportin " eLife. 2023 Jan ; 12 : e82947.
Pubmed PMID: 36648329.

Funding

Structure and mechanism of mammalian ferroportin #R01HL157473: (05/01/2021 - 04/30/2025); Grant funding from NIH; The major goal of this project is to understand the mechanism of iron transport and inhibition in ferroportin at the atomic resolution.