XIN LI, PhD
Assistant Professor
Positions
- Assistant Professor
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Biochemistry and Molecular Pharmacology
Baylor College of Medicine
Houston, Texas, United States
- Associate member
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Baylor College of Medicine
Dan L Duncan Comprehensive Cancer Center
Houston, Texas, United States
Addresses
- Baylor College of Medicine (Office)
-
1 Baylor Plaza
Alkek building, N510
Houston, TX, 77030
United States
Education
- Postdoctoral Fellowship at Baylor College of Medicine
- 04/2023 - Houston, Texas, United States
- Postdoctoral Fellowship at University of Houston
- 09/2019 - Houston, Texas, United States
- Postdoctoral Fellowship at Texas Tech University Health Sciences Center
- 09/2017 - Amarillo, Texas, United States
- PhD from Shandong University
- 06/2016 - Jinan, China
Professional Interests
- Drug Discovery, Medicinal Chemistry and Chemical Biology
Professional Statement
I am interested in the discovery and development of small-molecule inhibitors/degraders that selectively target biologically important proteins to dissect fundamental biological processes (chemical biology) and develop novel therapeutics (drug discovery).
I have received comprehensive academic training in medicinal chemistry and drug discovery. My training encompasses rational and computer-aided drug design, organic synthesis, and studies of drug evaluation and mechanisms of action. I have experience with a wide range of techniques, including recombinant protein expression and purification, biochemical assays (e.g., UV/fluorescence-based assays, AlphaScreen, ITC, and BLI), cellular assays, gene expression analysis, and in vivo studies.
I have over 10 years of wet-lab research experience in medicinal chemistry and drug discovery, with a track record of discovering and developing multiple classes of protein inhibitors and degraders in anti-infective and anticancer research. I have published approximately 40 peer-reviewed articles in journals including Journal of Hematology & Oncology, Theranostics, and Journal of Medicinal Chemistry.
These academic training and research experiences have provided me with a strong background in the discovery and development of novel chemical probes or drug leads, which could be used for the fundamental biology study or for the further drug development.
I have received comprehensive academic training in medicinal chemistry and drug discovery. My training encompasses rational and computer-aided drug design, organic synthesis, and studies of drug evaluation and mechanisms of action. I have experience with a wide range of techniques, including recombinant protein expression and purification, biochemical assays (e.g., UV/fluorescence-based assays, AlphaScreen, ITC, and BLI), cellular assays, gene expression analysis, and in vivo studies.
I have over 10 years of wet-lab research experience in medicinal chemistry and drug discovery, with a track record of discovering and developing multiple classes of protein inhibitors and degraders in anti-infective and anticancer research. I have published approximately 40 peer-reviewed articles in journals including Journal of Hematology & Oncology, Theranostics, and Journal of Medicinal Chemistry.
These academic training and research experiences have provided me with a strong background in the discovery and development of novel chemical probes or drug leads, which could be used for the fundamental biology study or for the further drug development.
Selected Publications
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Xin Li, Yuan Yao, Fangrui Wu, Yongcheng Song. " A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth " J Hematol Oncol. 2022 Apr 8; 2022 (15) : 41.
Pubmed PMID: 35395864. -
Md Ashraf-Uz-Zaman #, Xin Li #, Yuan Yao #, Chandra Bhushan Mishra, Bala Krishna Moku, and Yongcheng Song. " Quinazolinone Compounds Have Potent Antiviral Activity against Zika and Dengue Virus " J Med Chem. 2023 Jul 28;
Pubmed PMID: 37506506. -
Xin Li, Yongcheng Song. " Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy " J Hematol Oncol. 2020 May 13; 13 : 50.
Pubmed PMID: 32404196. -
Xin Li, Yongcheng Song. " Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins " J Hematol Oncol. 2021 Apr 6; 14 (1) : 56.
Pubmed PMID: 33823889.
Projects
- Medicinal Chemistry and Anticancer Drug Discovery
- Medicinal Chemistry and Antiviral Drug Discovery
Funding
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SynthX/Duncan Cancer Center Seed Award
- Grant funding from SynthX Center and the Duncan Cancer Center
Skills
- Rational and Computer-Aided Drug Design
- Docking, Molecular Modeling, Virtual Screening
- Synthetic Medicinal Chemistry
- Mechanism of Action Studies
- Drug Characterization In Vitro and In Vivo
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