Xia Gao

Assistant Professor

Email

xia.gao@bcm.edu

Positions

Assistant Professor: Pediatrics-Nutrition
Baylor College of Medicine

Assistant professor: Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States

Education

PhD from University of Alberta: Edmonton, Alberta, Canada

Postdoctoral Fellowship at Duke University: Durham, North Carolina, United States

Professional Statement

Nutritional input has direct impact on metabolism and metabolic health in humans, yet to what extent and how nutritional components influence the onset, development, and progression of diseases remains largely unknown. Further, can nutritional intervention be harnessed as standalone or adjunct therapy? We are interested in understanding the interactions of nutrition, metabolism, and metabolic disease, particularly amino acid metabolism in cancer and obesity.

Websites

pubmed

Selected Publications

Gao X, Lee K, Reid MA, Sanderson SM, Qiu C, Li S, Liu J, Locasale JW.. " Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism. " Cell Rep.. 2018 ;
Pubmed PMID: 29590619.
Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, Yagita H, Slingluff CL Jr, Hoehn KL, Rathmell JC, Bullock TNJ.. " Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells. " Sci Immunol.. 2019 ;
Pubmed PMID: 30683669.
Xu Q, Li Y, Gao X, Kang K, Williams JG, Tong L, Liu J, Ji M, Deterding LJ, Tong X, Locasale JW, Li L, Shats I, Li X.. " HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer " Nat Commun.. 2020 ;
Pubmed PMID: 32770044.
Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP Jr, Ciccarella A, Calcagnotto A, Mikhael PG, Mentch SJ, Liu J, Ables G, Kirsch DG, Hsu DS, Nichenametla SN, Locasale JW.. " Dietary methionine influences therapy in mouse cancer models and alters human metabolism " Nature. 2019 Aug ;
Pubmed PMID: 31367041.
Liang Y, Pan C, Yin T, Wang L, Gao X, Wang E, Quang H, Huang D, Tan L, Xiang K, Wang Y, Alexander PB, Li QJ, Yao TP, Zhang Z, Wang XF.. " Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype " Adv Sci. 2024 ;
Pubmed PMID: 37964763.
Juras PK, Racioppi L, Mukherjee D, Artham S, Gao X, Akullian D'Agostino L, Chang CY, McDonnell DP.. " Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells. " Cancer Immunol Res.. 2023 Jan ;
Pubmed PMID: 36301267.
Xu L, Zhao B, Butler W, Xu H, Song N, Chen X, Spencer Hauck J, Gao X, Zhang H, Groth J, Yang Q, Zhao Y, Moon D, George D, Zhou Y, He Y, Huang J.. " Targeting glutamine metabolism network for the treatment of therapy-resistant prostate cancer. " Oncogene. 2022 ;
Pubmed PMID: 35046532.
Xu L, Yin Y, Li Y, Chen X, Chang Y, Zhang H, Liu J, Beasley J, McCaw P, Zhang H, Young S, Groth J, Wang Q, Locasale JW, Gao X, Tang DG, Dong X, He Y, George D, Hu H, Huang J.. " A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer. " Proc Natl Acad Sci U S A.. 2021 ;
Pubmed PMID: 33753479.

Memberships

Dan L Duncan Comprehensive Cancer Center

Gulf Coast Center for Precision Environmental Health: member

Funding

Employing dietary methionine restriction to enhance chemotherapy efficacy #RP210056: (08/31/2021 - 08/30/2026); Grant funding from Cancer Prevention & Research Institute of Texas

Understanding methionine metabolism and its therapeutic potential in cancer #R00 CA237618-01A1: Grant funding from NIH/NCI