sandulac

Vlad Sandulache, M.D. Ph.D.

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Vlad Sandulache, M.D. Ph.D.

Associate Professor

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Positions

Associate Professor: Otolaryngology-Head & Neck Surgery
Baylor College of Medicine
Houston, Texas United States

Core Faculty: Center for Translational Research on Inflammatory Diseases (CTRID)
Michael E. DeBakey VA Medical Center
Baylor College of Medicine
Houston, Texas United States

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Addresses

Jamail Specialty Care Center (Clinic)
: 1977 Butler Blvd.
Suite E5.200
Houston, TX 77030
United States
Phone: (713) 798-5900

Education

MD-PhD from University of Pittsburgh School of Medicine: 05/2008 - Pittsburgh, United States

Residency at Baylor College of Medicine, Department of Otolaryngology Head and Neck Surgery: 06/2015 - Houston, Texas United States

Clinical Fellowship at University of Texas MD Anderson Cancer Center, Department of Head and Neck Surgery: 06/2016 - Houston, Texas United States

Certifications

Diplomate: American Board of Otolaryngology-Head and Neck Surgery

Professional Interests

Laryngeal and pharyngeal cancer
Thyroid cancer
Salivary gland neoplasm
Melanoma
Advanced skin cancer

Professional Statement

Vlad C. Sandulache MD, PhD is a board certified otolaryngologist specializing in Head and Neck Surgical Oncology. Dr. Sandulache earned his MD and PhD from the University of Pittsburgh, and completed his residency in Otolaryngology Head and Neck Surgery at Baylor College of Medicine. Following residency, Dr. Sandulache completed a clinical fellowship in the Department of Head and Neck Surgery at The University of Texas MD Anderson Cancer Center where he received advanced training in minimally invasive surgical techniques for pharyngeal and laryngeal malignancies including transoral robotic surgery (TORS) and transoral laser surgery.
Dr. Sandulache utilizes a multidisciplinary approach to the management of patients with head and neck cancer with active participation in both surgical and non-surgical clinical trials. His primary clinical expertise is in the management of early and advanced stage oropharyngeal and laryngeal cancer, salivary gland neoplasms and poorly differentiated and anaplastic thyroid carcinoma.
Dr. Sandulache maintains an active basic science and clinical research program focused on elucidating the link between cancer metabolism and treatment effectiveness. The goal of this research program is to develop personalized treatment strategies based on tumor genomic information and metabolic response to conventional and targeted treatment strategies. One application of this approach currently underway is development of more effective treatments for poorly differentiated and anaplastic thyroid carcinoma.

Websites

VIICTR Publications List

Center for Translational Research on Inflammatory Diseases (CTRID)

Selected Publications

Richardson PA, Kansara S, Chen GG, Sabichi A, Sikora AG, Parke RB, Donovan DT, Chiao E, Sandulache VC. "Treatment Patterns in Veterans with Laryngeal and Oropharyngeal Cancer and Impact on Survival.." Laryngoscope Investig Otolaryngol. 2018 Aug 9;4(3) Pubmed PMID: 30186958
Tam S, Sandulache VC, Metwalli KA, Rock CD, Eraj SA, Sheu T, El-Naggar AK, Fuller CD, Weber RS, Lai SY. "Incompletely treated malignancies of the major salivary gland: Toward evidence-based care.." Head Neck. 2018 Aug;40(8):1630-1638. Pubmed PMID: 29734482
Yu W, Chen Y, Dubrulle J, Stossi F, Putluri V, Sreekumar A, Putluri N, Baluya D, Lai SY, Sandulache VC. "Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism.." Sci Rep. 2018 Mar 9;8(1):4306. Pubmed PMID: 29523854
Sandulache VC, Michikawa C, Kataria P, Gleber-Netto FO, Bell D, Trivedi S, Rao X, Wang J, Zhao M, Jasser S, Myers JN, Pickering CR. "High-Risk TP53 Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma.." Clin Cancer Res. 2018 Apr 1;24(7):1727-1733. Pubmed PMID: 29330202

Krupar R, Hautmann MG, Pathak RR, Varier I, McLaren C, Gaag D, Hellerbrand C, Evert M, Laban S, Idel C, Sandulache V, Perner S, Bosserhoff AK, Sikora AG. "Immunometabolic Determinants of Chemoradiotherapy Response and Survival in Head and Neck Squamous Cell Carcinoma.." Am J Pathol. 2018 Jan;188(1):72-83. Pubmed PMID: 29107073
Rao SN, Zafereo M, Dadu R, Busaidy NL, Hess K, Cote GJ, Williams MD, William WN, Sandulache V, Gross N, Gunn GB, Lu C, Ferrarotto R, Lai SY, Cabanillas ME. "Patterns of Treatment Failure in Anaplastic Thyroid Carcinoma.." Thyroid. 2017 May;27(5):672-681. Pubmed PMID: 28068873
Pezzi TA, Mohamed ASR, Sheu T, Blanchard P, Sandulache VC, Lai SY, Cabanillas ME, Williams MD, Pezzi CM, Lu C, Garden AS, Morrison WH, Rosenthal DI, Fuller CD, Gunn GB. "Radiation therapy dose is associated with improved survival for unresected anaplastic thyroid carcinoma: Outcomes from the National Cancer Data Base.." Cancer. 2017 May 1;123(9):1653-1661. Pubmed PMID: 28026871
Sandulache VC, Williams MD, Lai SY, Lu C, William WN, Busaidy NL, Cote GJ, Singh RR, Luthra R, Cabanillas ME. "Real-Time Genomic Characterization Utilizing Circulating Cell-Free DNA in Patients with Anaplastic Thyroid Carcinoma.." Thyroid. 2017 Jan;27(1):81-87. Pubmed PMID: 27785980
Wangjie Yu, Yunyun Chen, Nagireddy Putluri, Cristian Coarfa, Matthew Robertson, Vasanta Putluri, Fabio Stossi, Julien Dubrulle, Michael Mancini, Jonathan Pang, Trung Nguyen, Dodge Baluya, Jeffrey Myers, Stephen Lai, Vlad Sandulache "Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma Metabolism toward Neutralization of Oxidative Stress." Cancer (Basel). 2020 Jun 24;12(6):1670.
Mitchell Frederick, Heath D Skinner, Sawad A Kazi, Andrew G Sikora, Vlad C Sandulache "High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung." 2020 Apr 14;10(1):6380.
J O Kemnade, H Elhalawani, P Castro, J Yu, S Lai, M Ittmann, A S R Mohamed, S Y Lai, C D Fuller, A G Sikora, V C Sandulache "CD8 infiltration is associated with disease control and tobacco exposure in intermediate-risk oropharyngeal cancer." 2020 Jan 14;10(1):243.
V Sandulache, Y Lei, L Heasley, M Chang, C Amos, E Sturgis, E Graboyes, E Chiao, N Rogus-Pulia, J Lewis, A Madabhushi, M Frederick, A Sabichi, M Ittmann, W Yarbrough, C Chung, R Ferrarotto, W Mai, H Skinner, U Duvvuri, P Gerngross, A Sikora "Innovations in risk-stratification and treatment of Veterans with oropharynx cancer; roadmap of the 2019 Field Based Meeting." 2020 Mar;102:104440.