Positions
- Assistant Professor
-
Departments of Pediatrics
Hematology-Oncology Cell & Gene Therapy
Baylor College of Medicine
Houston, Texas, United States
Education
- Postdoctoral Fellowship at National Institutes of Health
- Bethesda, United States
- Immunology and Vaccinology
- Postdoctoral Fellowship at University of Illinois College of Medicine
- Rockford, Illinois, United States
- Immunology and Vaccine development
- PhD from CSJM University & Central Drug Research Institute
- Lucknow, India
- Life Sciences
Professional Interests
- Novel chimeric antigen receptor (CAR) T cells for solid tumors
- Correlates of immune response - CAR T cell clinical trials
- Synthetic cell receptors for tumor immunotherapy
Professional Statement
I am a scientist trained in human immunology of prophylactic and therapeutic interventions. I conduct translational research with gene-modified T-cells for solid tumors in children and young adults. My focus is on development of synthetic receptor molecules including chimeric antigen receptor (CAR) and delineating immune responses in patients undergoing CAR T-cell therapy in clinical trials.
Selected Publications
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Konduri V, Joseph SK, Byrd TT, Nawas Z, Vazquez-Perez J, Hofferek CJ, Halpert MM, Liu D, Liang Z, Baig Y, Salsman VS, Oyewole-Said D, Tsimelzon A, Burns BA, Chen C, Levitt JM, Yao Q, Ahmed NM, Hegde M, Decker WK. " A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma " Sci Transl Med. 2021 May ; (13(592)) : eabc3196.
Pubmed PMID: 33952672. -
Fousek K, Watanabe J, Joseph SK, George A, An X, Byrd TT, Morris JS, Luong A, Martínez-Paniagua MA, Sanber K, Navai SA, Gad AZ, ......, Jang A, Baker ML, Varadarajan N, Hegde M, Kim YM, Heisterkamp N, Abdel-Azim H, Ahmed N. " CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression " Leukemia. 2021 ; 35 (1) : 75-89.
Pubmed PMID: 32205861. -
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holdago, BL, et al. Manno A, Srikanthan D, ......., Maris JM, Sorensen PHB, Ahmed N, Taylor MD.. " Locoregional delivery of CAR T-cells to the cerebrospinal fluid as effective therapy for metastatic medulloblastoma and ependymoma " Nat Med.. 2020 ; 26 (5) : 720-731.
Pubmed PMID: 32341580. -
Hegde M, Joseph SK, Pashankar F, LoRenzo D, Khaled S, Byrd, T, Navai S, Hicks MJ, Xu, M, Gerken C, Patricia K; Perera CS, Zhang H, Shree A, Dakhova O, Brawley VS, Grilley BJ, Gee A, Dotti P, Heslop HE, Brenner MK, Wels W, Gottschalk S, Ahmed N. " Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma " Nat Commun. 2020 ; 11 (1) : 3549.
Pubmed PMID: 32669548.
Memberships
- American Society of Gene & Cell Therapy
- Member
- Society for Immunotherapy of Cancer
- Member
- Dan L Duncan Comprehensive Cancer Center
- Associate Member
- Gulf Coast Consortia
- Member
Funding
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Developing Sarcoma-specific T-cell Platform for Grafting Chimeric Antigen Receptors
- Grant funding from The Faris Foundation Immunotherapy Award
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Research Award
- Grant funding from Sarcoma Foundation of America
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Targeting High-Risk Medulloblastoma Using Locally-Delivered Endoglin CAR-T
- Grant funding from Rally Foundation for Childhood Cancer Research Career Development Award
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Cell Engineering to Improve CAR-T Cell Therapy for Pediatric Sarcomas
- Grant funding from VICTORY Houston Inc.
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