Email

sujith.joseph@bcm.edu

Positions

Assistant Professor

Departments of Pediatrics
Hematology-Oncology Cell & Gene Therapy
Baylor College of Medicine
Houston, Texas United States

Education

Postdoctoral Fellowship at National Institutes of Health

Bethesda, United States

Immunology and Vaccinology

Postdoctoral Fellowship at University of Illinois College of Medicine

Rockford, Illinois United States

Immunology and Vaccine development

PhD from CSJM University & Central Drug Research Institute

Lucknow, India

Life Sciences

Professional Interests

• Novel chimeric antigen receptor (CAR) T cells for solid tumors
• Correlates of immune response - CAR T cell clinical trials
• Synthetic cell receptors for tumor immunotherapy

Professional Statement

I am a scientist trained in human immunology of prophylactic and therapeutic interventions. I conduct translational research with gene-modified T-cells for solid tumors in children and young adults. My focus is on development of synthetic receptor molecules including chimeric antigen receptor (CAR) and delineating immune responses in patients undergoing CAR T-cell therapy in clinical trials.

Websites

Selected Publications

• Konduri V, Joseph SK, Byrd TT, Nawas Z, Vazquez-Perez J, Hofferek CJ, Halpert MM, Liu D, Liang Z, Baig Y, Salsman VS, Oyewole-Said D, Tsimelzon A, Burns BA, Chen C, Levitt JM, Yao Q, Ahmed NM, Hegde M, Decker WK "A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma." Sci Transl Med. 2021 May;(13(592)):eabc3196. Pubmed PMID: 33952672
• Fousek K, Watanabe J, Joseph SK, George A, An X, Byrd TT, Morris JS, Luong A, Martínez-Paniagua MA, Sanber K, Navai SA, Gad AZ, ......, Jang A, Baker ML, Varadarajan N, Hegde M, Kim YM, Heisterkamp N, Abdel-Azim H, Ahmed N "CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression." Leukemia. 2021;35(1):75-89. Pubmed PMID: 32205861
• Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holdago, BL, et al. Manno A, Srikanthan D, ......., Maris JM, Sorensen PHB, Ahmed N, Taylor MD. "Locoregional delivery of CAR T-cells to the cerebrospinal fluid as effective therapy for metastatic medulloblastoma and ependymoma." Nat Med.. 2020;26(5):720-731. Pubmed PMID: 32341580
• Hegde M, Joseph SK, Pashankar F, LoRenzo D, Khaled S, Byrd, T, Navai S, Hicks MJ, Xu, M, Gerken C, Patricia K; Perera CS, Zhang H, Shree A, Dakhova O, Brawley VS, Grilley BJ, Gee A, Dotti P, Heslop HE, Brenner MK, Wels W, Gottschalk S, Ahmed N "Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma." Nat Commun. 2020;11(1):3549. Pubmed PMID: 32669548

Funding

Faris D. Virani Immunotherapy Award

(07/01/2019 - 06/30/2021) Gift funding from The Faris Foundation

Research Award

(06/01/2021 - 05/31/2022) Grant funding from Sarcoma Foundation of America

2019 Pediatric Cancer Research Grant

(11/01/2019 - 10/31/2022) Grant funding from V Foundation

Research Grant

(01/01/2021 - 12/31/2021) Grant funding from Curing Kids Cancer